Adavanced Glycated Endproducts and Development of CAD (AGENDA)
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ClinicalTrials.gov Identifier: NCT02089360
Recruitment Status : Unknown
Verified March 2014 by Zhang Qi, MD, Shanghai Jiao Tong University School of Medicine. Recruitment status was: Recruiting
First Posted : March 17, 2014
Last Update Posted : March 17, 2014
Shanghai Jiao Tong University School of Medicine
Information provided by (Responsible Party):
Zhang Qi, MD, Shanghai Jiao Tong University School of Medicine
Blood sample is prospectively taken from consecutive patients underwent coronary angiogram in our center, after getting informed consent from the patients. Serum level of advanced glycation end products (AGEs) was measured and the clinical features of patients (including angiographic results) were entered into our database. Clinical follow-up was performed for all patients, and the relationship between AGEs and paitents' outcome were analyzed. Further intervention will be adjusted according to the results,including clinical and basic research in lab.
Condition or disease
Serum levels of HMGB1, HMGB2, ADAM10, etc. will be measured in lab and animal studies will be designed to intervene the adverse interaction between abnormal serum concentration of AGEs, etc. and worse clinical results.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 90 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
patients underwent coronary angiogram
patients underwent coronary angiogram for suspected coronary artery disease and potential percutaneous coronary intervention
patients underwent coronary angiogram for other reasons, including pre-surgery examination
patients with severe co-morbidity, and life expectancy less than one-year