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Olaparib as Adjuvant Treatment in Patients With Germline BRCA Mutated High Risk HER2 Negative Primary Breast Cancer (OlympiA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02032823
Recruitment Status : Active, not recruiting
First Posted : January 10, 2014
Last Update Posted : December 4, 2019
Sponsor:
Collaborators:
Breast International Group
Frontier Science & Technology Research Foundation, Inc.
NRG Oncology
Myriad Genetic Laboratories, Inc.
Br.E.A.S.T. -Data Center & Operational Office Institut Jules Bordet
Merck Sharp & Dohme Corp.
Information provided by (Responsible Party):
AstraZeneca

Brief Summary:
Olaparib treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative primary breast cancer who have completed definitive local treatment and neoadjuvant or adjuvant chemotherapy

Condition or disease Intervention/treatment Phase
Breast Cancer Drug: Olaparib Drug: Placebo Phase 3

Detailed Description:

Patients will be randomised in 1:1 ratio to either olaparib or placebo. Randomisation will be stratified by Hormone receptor status (ER and/or PgR positive/HER2 negative versus TNBC), prior neoadjuvant versus adjuvant chemotherapy and prior platinum use for breast cancer.

Randomised patients will receive study treatment for up to a maximum of 12 months. All patients will have safety assessments every 2 weeks during the first month, every 4 weeks for the following 5 months and 3 monthly for the remaining 6 months of study treatment plus 30 days after its discontinuation. Following randomisation, all patients will be assessed regularly for signs, symptoms and evidence of disease recurrence by taking medical history, physical examination and mammogram/breast MRI. Efficacy assessments will be performed on a 3 monthly basis during the first 2 years, followed by 6 monthly assessments for years 3, 4 and 5 and annually thereafter. All patients (except those with bilateral mastectomy) will have mammogram / breast MRI annually for 10 years beginning 6 months after randomisation.

All randomised patients will have clinical assessment visits for 10 years following their randomisation into the study. Once a patient completes 10 years of clinical assessment they will enter the survival follow up phase of the trial which will continue until 10 years after the last patient is randomised.

Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 1838 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: A Randomised, Double-blind, Parallel Group, Placebo-controlled Multi-centre Phase III Study to Assess the Efficacy and Safety of Olaparib Versus Placebo as Adjuvant Treatment in Patients With gBRCA1/2 Mutations and High Risk HER2 Negative Primary Breast Cancer Who Have Completed Definitive Local Treatment and Neoadjuvant or Adjuvant Chemotherapy
Actual Study Start Date : April 22, 2014
Estimated Primary Completion Date : October 9, 2020
Estimated Study Completion Date : November 27, 2028

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Breast Cancer
Drug Information available for: Olaparib

Arm Intervention/treatment
Experimental: Olaparib
Olaparib tablets 300mg b.i.d. p.o.
Drug: Olaparib
Patients will be administred olaparib orally twice daily (b.i.d.) at 300 mg. Two (2) x 150 mg olaparib tablets should be taken at the same times each morning and evening of each day, approximately 12 hours apart with approximately 240 ml of water.
Other Name: Lynparza

Placebo Comparator: Placebo
Placebo tablets b.i.d. p.o.
Drug: Placebo
Patients will be administred matching placebo. Two (2) tablets should be taken at the same times each morning and evening of each day, approximately 12 hours apart with approximately 240 ml of water.




Primary Outcome Measures :
  1. Invasive Disease Free Survival (IDFS) [ Time Frame: Up to 10 years ]
    Time from randomisation to date of first treatment failure that is loco-regional or distant recurrence or new cancer or death from any cause


Secondary Outcome Measures :
  1. Overall survival (OS) [ Time Frame: Until 10 years after the last patient is randomised ]
    Efficacy by assessment of OS (time from randomisation to death by any cause).

  2. Distant Disease Free Survival (DDFS) [ Time Frame: Up to 10 years ]
    Time from randomisation until documented evidence of first distant recurrence of breast cancer

  3. Effect on the incidence of new primary contralateral breast cancers, new primary ovarian cancer, new primary fallopian tube cancer and new primary peritoneal cancer [ Time Frame: Up to 10 years ]
    Time from randomisation until documented incidence of new primary contralateral breast cancers, new primary ovarian cancer, new primary fallopian tube cancer and new primary peritoneal cancer

  4. Effect in patients identified as having a deleterious or suspected deleterious variant in either of the BRCA genes using variants identified with current and future BRCA mutation assays. [ Time Frame: Up to LSLV & 15 years thereafter ]
    Retrospective analysis of samples

  5. Exposure to Olaparib (in plasma) in patients receiving Olaparib as adjuvant therapy [ Time Frame: Visit 4, day 29 ]
    Pharmacokinetic analysis

  6. FACIT-Fatiure symptoms and EORTC QLQ-C30 Questionnaires [ Time Frame: Up to 2 years ]
    Assess weather olaparib arm patients may experience greater fatigue (FACIT-Fatigue), greater GI symptoms and no difference in Quality of Life (EORTC QLQ-C30)


Other Outcome Measures:
  1. Safety and tolerability of olaparib [ Time Frame: 12 months of study treatment + 30 days after treatment discontinuation ]
    Assessment of Adverse Events (AE), physical examination, vital signs including blood pressure (BP), pulse, and laboratory findings including clinical chemistry and haematology



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 130 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Histologically confirmed non-metastatic primary invasive adenocarcinoma of the breast that is one of the following phenotypes:

    1. Triple negative breast cancer defined as: ER and PgR negative AND HER2 negative (not eligible for anti-HER2 therapy)
    2. ER and/or PgR positive, HER2 negative
  • Documented germline mutation in BRCA1 or BRCA2 that is predicted to be deleterious or suspected deleterious (known or predicted to be detrimental/lead to loss of function).
  • Completed adequate breast and axilla surgery.
  • Completed at least 6 cycles neoadjuvant or adjuvant chemotherapy containing anthracyclines, taxanes or the combination of both. Prior platinum as potentially curative treatment for prior cancer (e.g. ovarian) or as adjuvant or neoadjuvant treatment for breast cancer is allowed.
  • ECOG 0-1.

Exclusion criteria:

  • Any previous treatment with a PARP inhibitor, including olaparib and/or known hypersensitivity to any of the excipients of study treatment.
  • Patients with second primary malignancy. EXCEPTIONS are:

    1. adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, Ductal Carcinoma in situ (DCIS) of the breast, stage 1 grade 1 endometrial carcinoma
    2. other solid tumours and lymphomas (without bone marrow involvement) diagnosed ≥ 5 years prior to randomisation and treated with no evidence of disease recurrence and for whom no more than one line of chemotherapy was applied.
  • Concomitant use of known strong CYP3A inhibitors (e.g., itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (e.g., ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting study treatment is 2 weeks. Concomitant use of known strong (e.g., phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or moderate CYP3A inducers (e.g., bosentan, efavirenz, modafinil). The required washout period prior to starting study treatment is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents.
  • Evidence of metastatic breast cancer

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02032823


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Anchorage, Alabama, United States, 99508
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San Miguel de Tucuman, Argentina, T4000IAK
Research Site
Santa Fe, Argentina, S3000FFU
Australia
Research Site
Adelaide, Australia, 5000
Research Site
Auchenflower, Australia, 4066
Research Site
Concord, Australia, 2139
Research Site
Gosford, Australia, 2250
Research Site
Malvern, Australia, 3144
Research Site
Melbourne, Australia, 3000
Research Site
Nedlands, Australia, 6009
Research Site
Randwick, Australia, 2031
Research Site
South Brisbane, Australia, 4101
Research Site
Waratah, Australia, 2298
Research Site
Wendouree, Australia, 3355
Austria
Research Site
Graz, Austria, 8036
Research Site
Innsbruck, Austria, 6020
Research Site
Leoben, Austria, 8700
Research Site
Linz, Austria, 4010
Research Site
Linz, Austria, 4020
Research Site
Salzburg, Austria, 5020
Research Site
St. Veit an der Glan, Austria, 9300
Research Site
Vienna, Austria, 1130
Research Site
Vienna, Austria, 1160
Research Site
Voecklabruck, Austria, 4840
Research Site
Wels, Austria, 4600
Research Site
Wien, Austria, 1090
Research Site
Wien, Austria, 1130
Belgium
Research Site
Brussels, Belgium, 1000
Research Site
Brussels, Belgium, 1070
Research Site
Brussels, Belgium, 1090
Research Site
Bruxelles, Belgium, 1200
Research Site
Charleroi, Belgium, 6000
Research Site
Edegem, Belgium, 2650
Research Site
Kortrijk, Belgium, 8500
Research Site
Leuven, Belgium, 3000
Research Site
Liege, Belgium, 4000
Research Site
Namur, Belgium, 5000
Research Site
Oostende, Belgium, 8400
Canada, British Columbia
Research Site
Vancouver, British Columbia, Canada, V5Z 4E6
Canada, Manitoba
Research Site
Winnipeg, Manitoba, Canada, R3E 0V9
Canada, Ontario
Research Site
Hamilton, Ontario, Canada, L8V 5C2
Research Site
Toronto, Ontario, Canada, M4N 3M5
Canada, Quebec
Research Site
Greenfield Park, Quebec, Canada, J4V 2H1
Research Site
Montreal, Quebec, Canada, H2W 1T8
Research Site
Montreal, Quebec, Canada, H3T 1E2
Canada, Saskatchewan
Research Site
Regina, Saskatchewan, Canada, S4T 7T1
Research Site
Saskatoon, Saskatchewan, Canada, S7N 4H4
Canada
Research Site
Quebec, Canada, G1S 4L8
China
Research Site
Beijing, China, 100006
Research Site
Beijing, China, 100021
Research Site
Beijing, China, 100730
Research Site
Changchun, China, 130061
Research Site
Chengdu, China, 610041
Research Site
Fuzhou, China, 350001
Research Site
Guangzhou, China, 510100
Research Site
Hangzhou, China, 310003
Research Site
Hangzhou, China, 310022
Research Site
Harbin, China, 150081
Research Site
Ji Nan, China, 2501117
Research Site
Nanjing, China, 210029
Research Site
Shanghai, China, 200025
Research Site
Shanghai, China, 200032
Research Site
Shijiazhuang, China, 050035
Research Site
Tianjin, China, 300060
France
Research Site
Avignon, France, 84918
Research Site
Besancon, France, 25030
Research Site
Bordeaux Cedex, France, 33076
Research Site
Brest Cedex, France, 29609
Research Site
Caen Cedex 05, France, 14076
Research Site
Clermont Ferrand cedex 01, France, 63011
Research Site
Dechy, France, 59187
Research Site
La Roche sur Yon, France, 85025
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Lille Cedex, France, 59020
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Limoges Cedex, France, 87042
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Lyon Cedex 08, France, 69373
Research Site
Marseille cedex 09, France, 13273
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Marseille, France
Research Site
Montpellier, France, 34298
Research Site
Nantes, France, 44202
Research Site
Nice, France, 06100
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Paris Cedex 10, France, 75010
Research Site
Plerin SUR MER, France, 22190
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Rennes, France, 35042
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Rouen, France, 76038
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Saint Cloud, France, 92211
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STRASBOURG Cedex, France, 67065
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Toulouse Cedex 3, France, 31076
Research Site
Villejuif Cedex, France, 94805
Germany
Research Site
Aachen, Germany, 52074
Research Site
Augsburg, Germany, 86150
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Berlin, Germany, 10117
Research Site
Berlin, Germany, 10367
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Berlin, Germany, 13125
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Berlin, Germany, 13589
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Berlin, Germany, 14169
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Bottrop, Germany, 46236
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Bremen, Germany, 28177
Research Site
Chemnitz, Germany, 09116
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Deggendorf, Germany, 94469
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Dresden, Germany, 01307
Research Site
Düsseldorf, Germany, 40225
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Düsseldorf, Germany, 40235
Research Site
Ebersberg, Germany, 85560
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Eggenfelden, Germany, 84307
Research Site
Erfurt, Germany, 99085
Research Site
Erlangen, Germany, 91054
Research Site
Essen, Germany, 45136
Research Site
Essen, Germany, 45147
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Frankfurt am Main, Germany, 65929
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Freiburg im Breisgau, Germany, 79106
Research Site
Fulda, Germany, 36043
Research Site
Fürth, Germany, 90766
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Gera, Germany, 07548
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Halle, Germany, 06120
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Hamburg, Germany, 20246
Research Site
Hameln, Germany, 31785
Research Site
Hannover, Germany, 30625
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Hildesheim, Germany, 31134
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Kassel, Germany, 34117
Research Site
Koblenz Am Rhein, Germany, 56068
Research Site
Köln, Germany, 50924
Research Site
Leipzig, Germany, 04103
Research Site
Mainz Am Rhein, Germany, 55131
Research Site
Mannheim, Germany, 68167
Research Site
Memmingen, Germany, 87700
Research Site
Mühlhausen, Germany, 99974
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Mühlheim An Der Ruhr, Germany, 45468
Research Site
München, Germany, 80337
Research Site
Münster, Germany, 48149
Research Site
Nordhausen, Germany, 99734
Research Site
Offenbach am Main, Germany, 63069
Research Site
Onkologisch Hämatologische Sch, Germany, 28209
Research Site
Paderborn, Germany, 33098
Research Site
Ravensburg, Germany, 88212
Research Site
Recklinghausen, Germany, 45659
Research Site
Saarbrücken, Germany, 66113
Research Site
Stendal, Germany, 39576
Research Site
Tübingen, Germany, 72076
Research Site
Ulm, Germany, 89075
Hungary
Research Site
Budapest, Hungary, 1122
Research Site
Budapest, Hungary, 1145
Iceland
Research Site
Reykjavík, Iceland, 101
Israel
Research Site
Jerusalem, Israel, 91120
Research Site
Petah Tikva, Israel, 49100
Research Site
Ramat Gan, Israel, 5265601
Research Site
Tel-Aviv, Israel, 64239
Italy
Research Site
Bergamo, Italy, 24128
Research Site
Bologna, Italy, 40138
Research Site
Bolzano, Italy, 39100
Research Site
Castellanza Varese, Italy, 21053
Research Site
Lecce, Italy, 73100
Research Site
Legnago, Italy, 37045
Research Site
Milano, Italy, 20132
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Milano, Italy, 20141
Research Site
Modena, Italy, 41100
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Napoli, Italy, 80131
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Nehrar, Italy, 37024
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Padova, Italy, 35128
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Palermo, Italy, 90146
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Pavia, Italy, 27100
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Perugia, Italy, 06132
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Prato, Italy, 59100
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Rimini, Italy, 47923
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Varese, Italy, 21100
Research Site
Viterbo, Italy, 01100
Japan
Research Site
Chiba-shi, Japan, 260-8717
Research Site
Chuo-ku, Japan, 104-0045
Research Site
Chuo-ku, Japan, 104-8560
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Fukuoka-shi, Japan, 811-1395
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Hidaka-shi, Japan, 350-1298
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Hiroshima-shi, Japan, 730-8518
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Isehara-shi, Japan, 259-1193
Research Site
Kagoshima-shi, Japan, 892-0833
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Kashiwa, Japan, 277-8577
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Kawasaki-shi, Japan, 216-8511
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Koto-ku, Japan, 135-8550
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Kyoto-shi, Japan, 606-8507
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Matsuyama-shi, Japan, 791-0280
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Morioka-shi, Japan, 020-8505
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Nagoya-shi, Japan, 464-8681
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Nagoya-shi, Japan, 467-8601
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Nankoku-shi, Japan, 783-8505
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Niigata-shi, Japan, 951-8566
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Osaka-shi, Japan, 540-0006
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Osaka-shi, Japan, 541-8567
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Ota-shi, Japan, 373-8550
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Sapporo-shi, Japan, 003-0804
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Shinagawa-ku, Japan, 142-8666
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Suita-shi, Japan, 565-0871
Research Site
Sunto-gun, Japan, 411-8777
Korea, Republic of
Research Site
Daegu, Korea, Republic of, 41404
Research Site
Goyang-si, Korea, Republic of, 10408
Research Site
Incheon, Korea, Republic of, 21565
Research Site
Seongnam-si, Korea, Republic of, 13620
Research Site
Seoul, Korea, Republic of, 03080
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Seoul, Korea, Republic of, 03722
Research Site
Seoul, Korea, Republic of, 05505
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Seoul, Korea, Republic of, 135-710
Research Site
Seoul, Korea, Republic of, 158-710
Netherlands
Research Site
Amsterdam, Netherlands, 1066 CX
Research Site
Breda, Netherlands, 4819 EV
Research Site
Geleen, Netherlands, 6162 BG
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Leiden, Netherlands, 2333 ZA
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Maastricht, Netherlands, 6202 AZ
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Rotterdam, Netherlands, 3015 GD
Research Site
Zaandam, Netherlands, 1502 DV
Poland
Research Site
Gdańsk, Poland, 80-214
Research Site
Grzepnica, Poland, 72-003
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Olsztyn, Poland, 10-228
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Poznan, Poland, 60-693
Research Site
Warszawa, Poland, 01-748
Research Site
Warszawa, Poland, 02-781
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Łódź, Poland, 93-338
Portugal
Research Site
Lisboa, Portugal, 1099-023
Research Site
Lisboa, Portugal, 1400-038
Research Site
Lisboa, Portugal, 1500-650
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Lisboa, Portugal, 1998-018
Research Site
Loures, Portugal, 2674-514
Research Site
Porto, Portugal, 4200-072
Puerto Rico
Research Site
San Juan, Puerto Rico, 00936
Spain
Research Site
A Coruña, Spain, 15006
Research Site
Avila, Spain, 5004
Research Site
Badajoz, Spain, 06008
Research Site
Badalona, Spain, 08916
Research Site
Barcelona, Spain, 08025
Research Site
Barcelona, Spain, 08028
Research Site
Barcelona, Spain, 08035
Research Site
Castellón, Spain, 12002
Research Site
Cáceres, Spain, 10003
Research Site
Córdoba, Spain, 14004
Research Site
Girona, Spain, 17007
Research Site
Hosp de Llobregat(Barcelona), Spain, 08907
Research Site
Jaén, Spain, 23007
Research Site
La Laguna (Tenerife), Spain, 38320
Research Site
Lugo, Spain, 27003
Research Site
Lérida, Spain, 25198
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Madrid, Spain, 28007
Research Site
Madrid, Spain, 28033
Research Site
Madrid, Spain, 28034
Research Site
Madrid, Spain, 28040
Research Site
Madrid, Spain, 28041
Research Site
Malaga, Spain, 29010
Research Site
Palma de Mallorca, Spain, 07010
Research Site
Pamplona, Spain, 31008
Research Site
Pozuelo De AlarconMadrid, Spain, 28223
Research Site
Pozuelo de Alarcon, Spain, 28223
Research Site
Reus,Tarragona, Spain, 43204
Research Site
Sabadell(Barcelona), Spain, 08208
Research Site
Salamanca, Spain, 37007
Research Site
San Sebastián, Spain, 20014
Research Site
Santiago de Compostela, Spain, 15706
Research Site
Sevilla, Spain, 41009
Research Site
Sevilla, Spain, 41013
Research Site
Terrassa(Barcelona), Spain, 08227
Research Site
Toledo, Spain, 45004
Research Site
Valencia, Spain, 46009
Research Site
Valencia, Spain, 46010
Research Site
Zaragoza, Spain, 50009
Sweden
Research Site
Göteborg, Sweden, 413 45
Research Site
Linköping, Sweden, 581 85
Research Site
Malmö, Sweden, 20502
Research Site
Solna, Sweden, 171 64
Research Site
Stockholm, Sweden, 118 83
Research Site
Umeå, Sweden, 901 85
Switzerland
Research Site
Bern, Switzerland, 3010
Research Site
Lausanne, Switzerland, 1011
Research Site
Zürich, Switzerland, 8091
Taiwan
Research Site
Changhua, Taiwan
Research Site
Kaohsiung, Taiwan, 80756
Research Site
Taichung, Taiwan, 40447
Research Site
Taichung, Taiwan, 407
Research Site
Tainan City, Taiwan, 73657
Research Site
Tainan, Taiwan, 70403
Research Site
Taipei, Taiwan, 10048
Research Site
Taipei, Taiwan, 10449
Research Site
Taipei, Taiwan, 11217
Research Site
Taipei, Taiwan, 11490
Research Site
Taoyuan, Taiwan, 333
United Kingdom
Research Site
Belfast, United Kingdom, BT9 7AB
Research Site
Birmingham, United Kingdom, B15 2TG
Research Site
Bournemouth, United Kingdom, BH7 7DW
Research Site
Bristol, United Kingdom, BS2 8ED
Research Site
Cambridge, United Kingdom, CB2 0QQ
Research Site
Cardiff., United Kingdom, CF14 2TL
Research Site
Dudley, United Kingdom, DY1 2HQ
Research Site
Edinburgh, United Kingdom, EH4 2XU
Research Site
Glasgow, United Kingdom, G12 0YN
Research Site
Leeds, United Kingdom, LS9 7TF
Research Site
London, United Kingdom, E1 1BB
Research Site
London, United Kingdom, NW1 2BU
Research Site
London, United Kingdom, SE1 9RT
Research Site
London, United Kingdom, SW17 0QT
Research Site
London, United Kingdom, SW3 6JJ
Research Site
Manchester, United Kingdom, M20 4BX
Research Site
Nottingham, United Kingdom, NG5 1PB
Research Site
Oxford, United Kingdom, OX3 7LE
Research Site
Sheffield, United Kingdom, S10 2SJ
Research Site
Southampton, United Kingdom, SO16 6YD
Research Site
Stoke-on-Trent, United Kingdom, ST4 6QG
Research Site
Sutton, United Kingdom, SM2 5PT
Sponsors and Collaborators
AstraZeneca
Breast International Group
Frontier Science & Technology Research Foundation, Inc.
NRG Oncology
Myriad Genetic Laboratories, Inc.
Br.E.A.S.T. -Data Center & Operational Office Institut Jules Bordet
Merck Sharp & Dohme Corp.
Investigators
Layout table for investigator information
Principal Investigator: Andrew Tutt, Doctor of Medicine Integrated Cancer Centre Guy's Hospital, King's College, London School of Medicine, London, UK
Principal Investigator: Bella Kaufman, Doctor of Medicine Sheba Medical Center, Breast Cancer Unit, 52621 Tel Hashomer, Israel
Principal Investigator: Judy Garber, Doctor of Medicine Harvard Medical School, Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Susan F. Smither Center for Women's Cancers, 450 Brookline Avenue, Boston; MA 02215, US
Principal Investigator: Charles Geyer, Doctor of Medicine Virginia Commonwealth University Massey Cancer Center, McGlothlin Medical Education Center, Room 12-217, 1201 East Marshall St., PO Box 980070, Richmond, VA 23298-0070, USA

Additional Information:
Layout table for additonal information
Responsible Party: AstraZeneca
ClinicalTrials.gov Identifier: NCT02032823    
Other Study ID Numbers: D081CC00006
NSABP B-55 ( Other Identifier: NSABP )
BIG 6-13 ( Other Identifier: Breast International Group )
First Posted: January 10, 2014    Key Record Dates
Last Update Posted: December 4, 2019
Last Verified: December 2019
Keywords provided by AstraZeneca:
Breast Cancer
Adjuvant
Olaparib
BRCA 1/2
HER2
Additional relevant MeSH terms:
Layout table for MeSH terms
Breast Neoplasms
Neoplasms by Site
Neoplasms
Breast Diseases
Skin Diseases
Olaparib
Poly(ADP-ribose) Polymerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents