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Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01897532
Recruitment Status : Completed
First Posted : July 12, 2013
Results First Posted : January 25, 2019
Last Update Posted : April 4, 2019
Eli Lilly and Company
Information provided by (Responsible Party):
Boehringer Ingelheim

Brief Summary:
The aim of the study is to investigate the longterm impact on cardiovascular morbidity, mortality and renal function of treatment with linagliptin in a selected population of patients with Type 2 diabetes mellitus (T2DM) and to compare outcomes against placebo, on a background of standard of care.

Condition or disease Intervention/treatment Phase
Diabetes Mellitus, Type 2 Drug: Placebo Drug: Linagliptin Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6991 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Treatment
Official Title: CARMELINA: A Multicenter, International, Randomized, Parallel Group, Double-blind, Placebo-controlled, Cardiovascular Safety and Renal Microvascular Outcome Study With Linagliptin, 5 mg Once Daily in Patients With Type 2 Diabetes Mellitus at High Vascular Risk
Actual Study Start Date : July 10, 2013
Actual Primary Completion Date : January 18, 2018
Actual Study Completion Date : January 18, 2018

Resource links provided by the National Library of Medicine

Drug Information available for: Linagliptin

Arm Intervention/treatment
Experimental: Linagliptin Drug: Linagliptin
Placebo Comparator: Placebo Drug: Placebo
placebo matching tablets

Primary Outcome Measures :
  1. Time to the First Occurrence of Any of the Following Adjudication-confirmed Components of the Primary Composite Endpoint 3-point Major Adverse Cardiovascular (CV) Events (3-point MACE): CV Death, Non-fatal Myocardial Infarction (MI) or Non-fatal Stroke. [ Time Frame: From randomization to individual end of observation; up to 4.3 years ]
    Time to event analysis of patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE): CV death, non-fatal MI or non-fatal stroke. The percentage of observed patients with first occurrence of any of the following adjudication-confirmed components of the primary composite endpoint (3-point MACE) was reported.

Secondary Outcome Measures :
  1. Time to the First Occurrence of Any of the Following Adjudication-confirmed Components: Renal Death, Sustained End Stage Renal Disease (ESRD), or Sustained Decrease of 40% or More in Estimated Glomerular Filtration Rate (eGFR). [ Time Frame: From randomization to individual end of observation; up to 4.3 years ]

    Time to the first occurrence of any of the following adjudication-confirmed components: renal death, sustained ESRD, or sustained decrease of 40% or more in eGFR.

    The percentage of observed patients with first occurrence of any of the following adjudication-confirmed components: renal death, sustained ESRD, or sustained decrease of 40% or more in eGFR was reported.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion criteria:

  1. Documented diagnosis of T2DM before visit 1(screening).
  2. Male or female patients who are drug-naïve or pre-treated with any antidiabetic background medication, excluding treatment with Glucagon-like Peptide 1 (GLP-1) receptor agonists, Dipeptidyl-peptidase 4 (DPP-4) inhibitors or Sodium Glucose Linked Transporter 2 (SGLT-2) inhibitors if => consecutive 7 days.
  3. Stable antidiabetic background medication (unchanged daily dose) for at least 8 weeks prior to randomization. If insulin is part of the background therapy, the average daily insulin dose should not have changed by more than 10% within the 8 weeks prior to randomization compared with the daily insulin dose at randomization.
  4. HbA1c of => 6.5% and <= 10.0% at Visit 1 (screening)
  5. Age => 18 years at Visit 1(screening). For Japan only: Age => 20 years at Visit 1
  6. Body Mass Index (BMI) <= 45 kg/m2 at Visit 1 (screening)
  7. Signed and dated written informed consent by date of Visit 1(screening) in accordance with Good Clinical Practice (GCP) and local legislation prior to any study related procedure
  8. High risk of cardiovascular (CV) events defined by: 1) albuminuria (micro or macro) and previous macrovascular disease and/or 2) impaired renal function with predefined Urine Albumin Creatinine Ratio (UACR)

Exclusion criteria:

  1. Type 1 diabetes mellitus.
  2. Treatment (=> 7 consecutive days) with GLP-1 receptor agonists, other DPP-4 inhibitors or SGLT-2 inhibitors prior to informed consent. Note: This also includes clinical trials where these antidiabetic drugs have been provided to the patient.
  3. Active liver disease or impaired hepatic function, defined by serum levels of either Alanine Transaminase (ALT) (SGPT), Aspartate transaminase (AST) (SGOT), or alkaline phosphatase (AP) => 3 x upper limit of normal (ULN) as determined at Visit 1.
  4. Estimated Glomerular filtration Rate (eGFR) <15 ml/min/1.73 m2 (severe renal impairment or End Stage Renal Disease (ESRD), Modification of Diet in Renal Disease (MDRD) formula), as determined during screening at Visit 1 and/or the need for maintenance dialysis.
  5. Any previous (or planned within next 12 months) bariatric surgery (open or laparoscopic) or intervention (gastric sleeve).
  6. Pre-planned coronary artery re-vascularisation (PCI, CABG) or any previous PCI and/or CABG <= 2 months prior informed consent.
  7. Known hypersensitivity or allergy to the investigational products or its excipients.
  8. Any previous or current alcohol or drug abuse that would interfere with trial participation in the opinion of the investigator.
  9. Participation in another trial with an investigational drug ongoing or within 2 months prior to visit 1 (screening).
  10. Pre-menopausal women (last menstruation = 1 year prior to informed consent) who are nursing or pregnant, are of child-bearing potential and are not practicing an acceptable method of birth control (acceptable methods of birth control include tubal ligation, transdermal patch, intra uterine devices/systems (IUDs/IUSs), oral, implantable or injectable contraceptives, sexual abstinence (if allowed by local authorities), double barrier method and vasectomised partner) or do not plan to continue using acceptable method of birth control throughout the study and do not agree to submit to periodic pregnancy testing during participation in the trial.
  11. Patients considered unreliable by the investigator concerning the requirements for follow up during the study and/or compliance with study drug administration, have a life expectancy less than 5 years for non-CV causes, or have cancer other than non-melanoma skin cancer within last 3 years, or has any other condition than mentioned which in the opinion of the investigator, would not allow safe participation in the study.
  12. Acute coronary syndrome (ACS), diagnosed <= 2 months prior to visit 1 (screening).
  13. Stroke or Transient Ischemic Attack (TIA) <= 3 months prior to visit 1 (screening).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01897532

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United States, Alabama
Longwood Research
Huntsville, Alabama, United States, 35801
Scottsboro Quick Care Clinic
Scottsboro, Alabama, United States, 35768
Office of Dr. Terence T. Hart MD
Tuscumbia, Alabama, United States, 35674
United States, Arizona
Arrowhead Health Centers
Glendale, Arizona, United States, 85306
Precision Trials, LLC
Phoenix, Arizona, United States, 85032
United States, Arkansas
Harrisburg Family Medical Center
Harrisburg, Arkansas, United States, 72432
Cardiology and Medicine Clinic
Little Rock, Arkansas, United States, 72204
Little Rock Diagnostic Clinic
Little Rock, Arkansas, United States, 72205
United States, California
Kaiser Permanente - San Diego, Bonita
Bonita, California, United States, 91902
John Muir Physician Network Clinical Research Center
Concord, California, United States, 94520
Valley Research
Fresno, California, United States, 93720
VA Loma Linda Healthcare System
Loma Linda, California, United States, 92357
Long Beach Center for Clinical Research
Long Beach, California, United States, 90807
Clearview Medical Research, LLC
Los Angeles, California, United States, 90019
National Research Institute
Los Angeles, California, United States, 90057
Office of Dr. Richard S. Cherlin
Los Gatos, California, United States, 95032
Coastal Medical Research Group
Los Osos, California, United States, 93402
Novo Research, Incorporated
Modesto, California, United States, 95350
Providence Clinical Research
North Hollywood, California, United States, 91606
Northridge Clinical Research Inc.
Northridge, California, United States, 91324
Carr Cardiology
Oceanside, California, United States, 92056
Center for Clinical Trials of Sacramento, Incorporated
Sacramento, California, United States, 95823
North America Research Institute
San Dimas, California, United States, 91773
Trinitas Research, Incorporated
San Jose, California, United States, 95116
Metabolic Institute of America
Tarzana, California, United States, 91356
Center for Clinical Trials of San Gabriel
West Covina, California, United States, 91790
United States, Colorado
Western Nephrology & Metabolic
Arvada, Colorado, United States, 80002
South Denver Nephrology
Denver, Colorado, United States, 80210
Colorado Center for Bone Research, P.C.
Golden, Colorado, United States, 80401
United States, Florida
Helix Biomedics LLC
Boynton Beach, Florida, United States, 33435
Orthopedic Research Institute
Boynton Beach, Florida, United States, 33437
Nova Clinical Research, LLC
Bradenton, Florida, United States, 34209
PAB Clinical Research
Brandon, Florida, United States, 33511
Meridien Research
Brooksville, Florida, United States, 34601
Southeast Clinical Research, LLC
Chiefland, Florida, United States, 32626
BayCare Medical Group
Clearwater, Florida, United States, 33756
Cohen Medical Research Associates, LLC
Delray Beach, Florida, United States, 33446
Innovation Medical Research Center, Inc
Doral, Florida, United States, 33166
Integrative Research Associates
Fort Lauderdale, Florida, United States, 33312
Jellinger and Lerman, MD, PA dba The Center for Diabetes and Endocrine Care
Fort Lauderdale, Florida, United States, 33312
Direct Helpers Medical Center, Inc
Hialeah, Florida, United States, 33012
Universal Clinical Research
Hialeah, Florida, United States, 33012
Homestead Associates in Research
Homestead, Florida, United States, 33032
St. Vincent's Cardiology
Jacksonville, Florida, United States, 32216
Care Partners Clinical Research LLC
Jacksonville, Florida, United States, 32277
Altus Research, Inc.
Lake Clarke Shores, Florida, United States, 33406
Meridien Research
Lakeland, Florida, United States, 33805
Precision Research Organization
Miami Lakes, Florida, United States, 33016
Clinical Research of Miami
Miami, Florida, United States, 33126
Prestige Clinical Research Center, Inc.
Miami, Florida, United States, 33133
Jesscan Medical Research, Internal Medicine
Miami, Florida, United States, 33134
Clintex Research Group, Inc. Research
Miami, Florida, United States, 33135
University of Miami
Miami, Florida, United States, 33136
Florida Medical Center & Research Inc
Miami, Florida, United States, 33142
A+ Research Incorporated
Miami, Florida, United States, 33144
Unlimited Medical Research, LLC
Miami, Florida, United States, 33144
Regenerate Clinical Trials
Miami, Florida, United States, 33155
Sanitas Research
Miami, Florida, United States, 33155
Future Care Solution, LLC
Miami, Florida, United States, 33165
Research Institute of South Florida Inc
Miami, Florida, United States, 33173
Tellus Clinical Research, Incorporated
Miami, Florida, United States, 33173
New Horizon Research Center
Miami, Florida, United States, 33175
Kendall South Medical Center, Inc
Miami, Florida, United States, 33185
Coral Research Clinic Corp
Miami, Florida, United States, 33186
School of Clinical Research
North Miami Beach, Florida, United States, 33144
Harmony Clinical Research, Incorporated
North Miami Beach, Florida, United States, 33162
Magnolia Research Group
Ocala, Florida, United States, 34471
Family Medical Center
Orlando, Florida, United States, 32806
Peninsula Research, Inc.
Ormond Beach, Florida, United States, 32174
Infinity Clinical Research, LLC
Plantation, Florida, United States, 33317
Meridien Research
Saint Petersburg, Florida, United States, 33709
Professional Health Care of Pinellas, Inc.
Saint Petersburg, Florida, United States, 33713
Intercoastal Medical Group, Endocrinology
Sarasota, Florida, United States, 34232
Meridien Research
Tampa, Florida, United States, 33634
Metabolic Research Institute
West Palm Beach, Florida, United States, 33401
United States, Georgia
Emory University
Atlanta, Georgia, United States, 30303
Laureate Clinical Research Group, LLC
Atlanta, Georgia, United States, 30308
Bainbridge Medical Associates
Bainbridge, Georgia, United States, 39819
Atlanta Heart Specialists, LLC
Cumming, Georgia, United States, 30041
McGarity, Jr., William C.
Decatur, Georgia, United States, 30035-4000
Atlanta Heart Specialists, LLC
Tucker, Georgia, United States, 30084
United States, Illinois
Belleville Family Medical Associates, Ltd
Belleville, Illinois, United States, 62220
Cedar-Crosse Research Center
Chicago, Illinois, United States, 60607
Chicago Clinical Research Institute, Inc.
Chicago, Illinois, United States, 60607
Associates in Endocrinology, Incorporated
Elgin, Illinois, United States, 60124
Kidney Care Center, Nephrology
Joliet, Illinois, United States, 60435
United States, Indiana
American Health Network
Avon, Indiana, United States, 46123
American Health Network of Indiana, LLC
Franklin, Indiana, United States, 46131
American Health Network of Indiana, LLC
Greenfield, Indiana, United States, 46140
American Health Network of Indiana, LLC
Muncie, Indiana, United States, 47304
Buynak Clinical Research
Valparaiso, Indiana, United States, 46383
United States, Iowa
Northeast Iowa Medical Education Foundation
Waterloo, Iowa, United States, 50702
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States, 50265
United States, Kansas
Cotton-O'Neil Clinical Research Center
Topeka, Kansas, United States, 66606
Professional Research Network of Kansas, LLC
Wichita, Kansas, United States, 67203
Heartland Research Associates, LLC
Wichita, Kansas, United States, 67205
United States, Kentucky
The Research Group of Lexington, LLC
Lexington, Kentucky, United States, 40503
United States, Louisiana
Diabetes and Metabolism Associates APMC
Metairie, Louisiana, United States, 70006
Tulane University Hospital and Clinic
New Orleans, Louisiana, United States, 70112
United States, Maryland
Maryland Cardiovascular Specialists
Baltimore, Maryland, United States, 21229
Overlea Personal Physicians
Baltimore, Maryland, United States, 21236
Johns Hopkins University
Baltimore, Maryland, United States, 21287
Delmarva Heart Research Foundation, Inc
Salisbury, Maryland, United States, 21804
United States, Michigan
Endeavor Medical Research
Alpena, Michigan, United States, 49707
University of Michigan Health System
Ann Arbor, Michigan, United States, 48105
Aa Mrc Llc
Flint, Michigan, United States, 48504
McLaren Northern Michigan Hospital
Petoskey, Michigan, United States, 49770
Remedica LLC
Rochester, Michigan, United States, 48307
Tri-County Research, Inc
Sterling Heights, Michigan, United States, 48310-3503
Oakland Medical Research Center
Troy, Michigan, United States, 48085
United States, Minnesota
HealthEast St. Joseph's Hospital
Saint Paul, Minnesota, United States, 55102
United States, Mississippi
Mississippi Medical Research, LLC
Carriere, Mississippi, United States, 39426
United States, Missouri
Truman Medical Centers, Inc.
Kansas City, Missouri, United States, 64108
Kansas City Veterans Administration Medical Center
Kansas City, Missouri, United States, 64128
United States, Montana
Glacier View Cardiology, PC
Kalispell, Montana, United States, 59901
United States, Nebraska
Platte River Nephrology
North Platte, Nebraska, United States, 69101
Omaha Veterans Affairs Medical Center
Omaha, Nebraska, United States, 68131
United States, Nevada
Alas Science Clinical Research
Las Vegas, Nevada, United States, 89120
United States, New Jersey
USMA Clin. Research/Union Square Med. Associates
Elizabeth, New Jersey, United States, 07201
Mount Sinai - PRIME
Linden, New Jersey, United States, 07036
United States, New Mexico
New Mexico Clinical Research and Osteoporosis Center, Inc.
Albuquerque, New Mexico, United States, 87106
United States, New York
Jacobi Medical Center
Bronx, New York, United States, 10461
Life Medi-Research and Management
Brooklyn, New York, United States, 11206
United Medical Associates
Johnson City, New York, United States, 13901
Saratoga Clinical Research, LLC
Saratoga Springs, New York, United States, 12866
United States, North Carolina
Kernodle Clinic West
Burlington, North Carolina, United States, 27215
Main Street Physicians Care
Calabash, North Carolina, United States, 28467
Box Arthritis & Rheumatology of the Carolinas
Charlotte, North Carolina, United States, 28210
Clinical Research of Gastonia
Gastonia, North Carolina, United States, 28054
Medication Management, LLC
Greensboro, North Carolina, United States, 27408
PMG Research of Bristol, LLC
Hickory, North Carolina, United States, 28601
Novant Health Southern Piedmont Primary Care
Monroe, North Carolina, United States, 28110
Research Institute of the Carolinas, PLC
Mooresville, North Carolina, United States, 28117
Down East Medical Associates
Morehead City, North Carolina, United States, 28557
Burke Primary Care
Morganton, North Carolina, United States, 28655
PMG Research of Salisbury, LLC
Salisbury, North Carolina, United States, 28144
Natalie A Doyle, M.D., P.A.
Wilson, North Carolina, United States, 27893
United States, Ohio
Summa Health System
Akron, Ohio, United States, 44304
Medical Frontiers, LLC
Carlisle, Ohio, United States, 45005
Dayton VA Medical Center
Dayton, Ohio, United States, 45428
Norton Community Care
Norton, Ohio, United States, 44203
Apex Medical Research, AMR, Incorporated
Springfield, Ohio, United States, 45505
ProMedica Health Education & Research Corp.
Toledo, Ohio, United States, 43606
United States, Oklahoma
COR Clinical Research, LLC
Oklahoma City, Oklahoma, United States, 73103
Lynn Health Science Institute
Oklahoma City, Oklahoma, United States, 73112
United States, Oregon
The Corvallis Clinic, PC
Corvallis, Oregon, United States, 97330
United States, Pennsylvania
Blair Medical Associates
Altoona, Pennsylvania, United States, 16602
Clinical Research Associates of Central Pennsylvania
Altoona, Pennsylvania, United States, 16602
Central Bucks Cardiology
Doylestown, Pennsylvania, United States, 18901
Doylestown Health Cardiology
Doylestown, Pennsylvania, United States, 18901
Lycoming Internal Medicine, Inc
Jersey Shore, Pennsylvania, United States, 17740
Montgomery Medical Incorporated
Smithfield, Pennsylvania, United States, 15478
United States, South Carolina
Clinical Trials of South Carolina
Charleston, South Carolina, United States, 29406
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Spectrum Medical Research, LLC
Gaffney, South Carolina, United States, 29341
VitaLink Research
Greenville, South Carolina, United States, 29615
Mountain View Clinical Research
Greer, South Carolina, United States, 29651
Vita Link Research- Rock Hill
Rock Hill, South Carolina, United States, 29732
United States, South Dakota
Health Concepts
Rapid City, South Dakota, United States, 57702
United States, Tennessee
Holston Medical Group
Bristol, Tennessee, United States, 37620
State of Franklin Healthcare Associates, PLLC
Johnson City, Tennessee, United States, 37604
United States, Texas
DCT- AACT, LLC dba Discovery Clinical Trials
Austin, Texas, United States, 78758
Rockwood Medical Clinic
Bedford, Texas, United States, 76022
Texas Health Physicians Group
Dallas, Texas, United States, 75218
Research Institute of Dallas
Dallas, Texas, United States, 75231
Ben Taub General Hospital
Houston, Texas, United States, 77030
Southwest Clinical Trials
Houston, Texas, United States, 77074
The Endocrine Center
Houston, Texas, United States, 77079
Texas Family Geriatrics Clinic
Houston, Texas, United States, 77082
Memorial Clinical Associates Research
Houston, Texas, United States, 77084
Break Through Medical Research
Irving, Texas, United States, 75039
Medical & Surgical Clinic
Irving, Texas, United States, 75061
West Memorial Family Practice
Katy, Texas, United States, 77450
Hill Country Medical Associates
New Braunfels, Texas, United States, 78130
Permian Research Foundation
Odessa, Texas, United States, 79761
Methodist Hospital Research Institute, Internal Medicine
Pearland, Texas, United States, 77584
Health Texas Research Institute
San Antonio, Texas, United States, 78228-6205
Covenant Clinical Research, PA
San Antonio, Texas, United States, 78229
DM Clinical Research
San Antonio, Texas, United States, 78249
DCT-Stone Oak, LLC dba Discovery Clinical Trials
San Antonio, Texas, United States, 78258
Sealy Urgent Care Center and Medical Clinic
Sealy, Texas, United States, 77474
Pioneer Research Solutions, Inc.
Sugar Land, Texas, United States, 77479
DM Clinical Research
Tomball, Texas, United States, 77375
Crossroads Clinical Research, LLC
Victoria, Texas, United States, 77901
United States, Utah
Ericksen Research & Development, LLC
Clinton, Utah, United States, 84015
Focus Clinical Research
Draper, Utah, United States, 84020
Advanced Research Institute
Ogden, Utah, United States, 84405
Paramount Medical Care
Ogden, Utah, United States, 84405
United States, Virginia
Burke Internal Medicine and Research
Burke, Virginia, United States, 22015
Nova Health Management & Research Group, PC
Herndon, Virginia, United States, 20170
Manassas Clinical Research Center
Manassas, Virginia, United States, 20110
Dominion Medical Associates, Inc.
Richmond, Virginia, United States, 23219
Hunter Holmes McGuire Veterans Administration Medical Center
Richmond, Virginia, United States, 23249
Roanoke Heart Institute PLC
Roanoke, Virginia, United States, 24014
Salem Veterans Affairs Medical Center
Salem, Virginia, United States, 24153
United States, Washington
Sound Medical Research
Port Orchard, Washington, United States, 98366
United States, Wisconsin
Zablocki VA Medical Center
Milwaukee, Wisconsin, United States, 53295
Instituto Médico Adrogué
Adrogue, Argentina, B1846DSK
Hospital Interzonal General de Agudos Dr Jose Penna
Bahia Blanca, Argentina, 8000
Inst de Inv Clinicas-Bahia Blanca
Bahia Blanca, Argentina, B8000FTD
Hospital Italiano Regional del Sur, Bahia Blanca
Bahia Blanca, Argentina, B8001HXM
Hospital Sirio-Libanés
Caba, Argentina, C1419GEP
Centro de Investigaciones Metabólicas
Ciudad Autonoma Buenos Aires, Argentina, C1056ABJ
Ciudad Autonoma Buenos Aires, Argentina, C1119ACN
Hospital Italiano
Ciudad Autonoma Buenos Aires, Argentina, C1181ACH
Consultorios Asociados de Endocrinología e Invest Clínica
Ciudad Autonoma Buenos Aires, Argentina, C1425AGC
CEDIC - Centro de Investigacion Clinica
Ciudad Autonoma Buenos Aires, Argentina, C1425DES
Instituto Cardiovascular de Buenos Aires
Ciudad Autonoma Buenos Aires, Argentina, C1428ART
CCBR - Buenos Aires - AR
Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
Centro Médico Viamonte
Ciudad Autonoma de Bs As, Argentina, C1120AAC
Centro Médico Colon
Cordoba, Argentina, 5000
CEMAIC - Centro Medico Especializado
Cordoba, Argentina, 5008
Inst. Privado de Inv. Clínicas de Córdoba
Cordoba, Argentina, X5000AAW
Clínica Colombo
Cordoba, Argentina, X5002AOQ
Instituto DAMIC - Fundacion Rusculleda
Cordoba, Argentina, X5003DCE
Hospital Cordoba
Cordoba, Argentina, X5004CDT
IPAC - Clínica Privada Caraffa SRL
Cordoba, Argentina, X5008KKF
Clinica Privada del Prado
Cordoba, Argentina, X5020AAA
Centro Universitario de Investigacion Corrientes
Corrientes, Argentina, W3400
Sanatorio Allende S.A.
Córdoba, Argentina, X5000JHQ
Godoy Cruz, Argentina, 5501
Centro Medico Dr. Javier Marino
Haedo, Argentina, B1706CZA
Hospital Italiano de La Plata
La Plata, Argentina, B1900AXI
Unidad de Cardiologia Clinica
Mar del Plata, Argentina, B7600FEN
Hospital Privado de Comunidad
Mar del Plata, Argentina, B7602CBM
Hospital Central de Mendoza, Mendoza
Mendoza, Argentina, 5500
Hospital San Martin
Parana, Argentina, E3100BBJ
Sanatorio San Martin S.A., Venado Tuerto
Pellegrini 661, Argentina, S2600KUE
CER Instituto Médico
Quilmes, Argentina, B1878DVB
Instituto de Investigaciones Clínicas de Quilmes
Quilmes, Argentina, B1878GEG
Instituto de Investigaciones Clinicas de Rosario
Rosario, Argentina, 2000
Instituto Medico de la Fundacion Estudios Clinicos, Rosario
Rosario, Argentina, 2000
Instituto Medico Fundación Grupo Colaborativo Rosario
Rosario, Argentina, 2000
Sanatorio Británico
Rosario, Argentina, 2000
Sanatorio Norte
Rosario, Argentina, 2000
Instituto de Hematologia y Medicina Clinica Ruben Davoli
Rosario, Argentina, CP2000
Sanatorio Delta
Rosario, Argentina, S2000BIF
Centro Medico CIR
Rosario, Argentina, S2000DEJ
Rosario, Argentina, S2000DNM
Instituto CAICI
Rosario, Argentina, S2000PBJ
Instituto Medico CENICLAR-C de Investigaciones Clinicas
Rosario, Argentina, S2000QID
Centro Cardiovascular Salta
Salta, Argentina, 4406
CORDIS S.A., Salta
Salta, Argentina, A4400ANW
Prevencion Cardiovascular Salta, Salta
Salta, Argentina, A4400CRC
CCBR Tucuman
San Miguel de Tucuman, Argentina, T4000
Investigaciones Clinicas Tucuman
San Miguel de Tucumán, Argentina, T4000ICL
Instituto de Investigaciones Clinicas San Nicolas
San Nicolas, Argentina, B2900DMH
Centro Medico Luquez
San Vicente, Argentina, X5006CBI
Centro de Investigaciones Clínicas del Litoral
Santa Fe, Argentina, S3000FWO
Hospital "Dr. José Maria Cullen "
Santa Fé, Argentina, S3000EOZ
Clinica Privada Fusavim SRL
Villa Maria, Argentina, X5900JKA
Instituto de Investigaciones Clínicas Zárate
Zarate, Argentina, 2800
Hospital Felício Rocho
Belo Horizonte, Brazil, 30110-060
Hospital Lifecenter
Belo Horizonte, Brazil, 30110-921
Hospital Vera Cruz
Belo Horizonte, Brazil, 30140-062
Hospital Universitário João de Barros Barreto
Belém, Brazil, 66073-000
Hospital Angelina Caron
Campina Grande do Sul, Brazil, 83430-000
HMCP - Hospital e Maternidade Celso Pierro - PUC-Campinas
Campinas, Brazil, 13060-904
CAEP - Centro Avançado de Estudos e Pesquisas Ltda.,Campinas
Campinas, Brazil, 13087-567
Hospital Universitário
Canoas, Brazil, 92425-900
Universidade de Caxias do Sul - IPCEM - Inst. de Pesq.clilni
Caxias do Sul, Brazil, 95070-560
Hospital de Caridade Santa Casa de Misericordia de Curitiba
Curitiba, Brazil, 80010-030
Curitiba, Brazil, 80030-110
Cruz Vermelha Brasileira - Filial do Estado do Paraná
Curitiba, Brazil, 80030-480
Centro de Estudos em Diabetes e Hipertensão
Fortaleza, Brazil, 60115-282
Centro de Pesquisas em Diabetes e Doenças
Fortaleza, Brazil, 60430-350
ICE-HUWC - Instituto Cearense de Endocrinologia
Fortaleza, Brazil, 60430-370
Via Médica
Goiania, Brazil, 74223-130
Hospital Bruno Born
Lajeado, Brazil, 95900-000
ICM - Instituto do Coração de Marília
Marília, Brazil, 17515-000
Hospital São Vicente de Paulo
Passo Fundo, Brazil, 99010-080
Irmandade da Santa Casa de Misericórdia de Porto Alegre
Porto Alegre, Brazil, 90035-074
Centro de Pesquisas em Diabetes
Porto Alegre, Brazil, 90035-170
Instituto de Cardiologia Rio Grande do Sul
Porto Alegre, Brazil, 90620-001
Centro de Pesquisas Médicas Básica e Clínica Ltda
Recife, Brazil, 52020-010
CCBR - Rio de Janeiro - BR
Rio de Janeiro, Brazil, 22271-100
Centro de Pesquisa Clínica Santa Maria
Santa Maria, Brazil, 97015-530
CCBR Brasil - São Paulo
Santo Andre, Brazil, 09190510
Instituto Domingo Braile
Sao Jose do Rio Preto, Brazil, 15015-750
Fundacao Faculdade Regional de Medicina, Sao Jose
Sao Jose do Rio Preto, Brazil, 15090-000
Centro de Pesquisa Clinica - CPCLIN
Sao Paulo, Brazil, 01244-030
FGM Clínica Paulista de Doenças Cardiovasculares LTDA
Sao Paulo, Brazil, 01327-010
Hospital Sao Paulo - UNIFESP
Sao Paulo, Brazil, 04022-001
Cpquali Pesquisa Clinica Ltda
São Paulo, Brazil, 01228-000
Hospital Alemao Oswaldo Cruz
São Paulo, Brazil, 01323-903
Hospital do Servidor Público Estadual
São Paulo, Brazil, 04039-901
Dr. Consulta
São Paulo, Brazil, 04254-020
Hospital das Clinicas da FMUSP
São Paulo, Brazil, 05403-000
Incor - Instituto do Coração - HCFMUSP
São Paulo, Brazil, 05403-000
IMC - Instituto de Moléstias Cardiovasculares Tatuí
Tatui, Brazil, 18270-170
ICT - Instituto do Coração do Triângulo
Uberlândia, Brazil, 38400-368
MHAT - Blagoevgrad, EOOD
Blagoevgrad, Bulgaria, 2700
MHAT "Yuliya Vrevska" EOOD, Byala
Byala, Bulgaria, 7100
MHAT "Dr.Stambolski", Cardiology&Intensiv Care Dept,Kazanlak
Kazanlak, Bulgaria, 6100
UMHAT "Kaspela", EOOD, Plovdiv
Plovdiv, Bulgaria, 4002
DCC 1 - Ruse, EOOD
Ruse, Bulgaria, 7002
Fifth MHAT - Sofia EAD, Sofia
Sofia, Bulgaria, 1233
MHAT Lyulin
Sofia, Bulgaria, 1336
MHAT 'Tokuda Hospital Sofia', EAD
Sofia, Bulgaria, 1407
USHATE Hospital 'Academy Ivan Penchev', Sofia
Sofia, Bulgaria, 1431
DCC "Equita" EOOD
Varna, Bulgaria, 9000
Canada, Alberta
ALTA Clinical Research Inc.
Edmonton, Alberta, Canada, T5A 4L8
The Bailey Clinic
Red Deer, Alberta, Canada, T4N 6V7
Canada, British Columbia
Dr. Ronald Collette
Burnaby, British Columbia, Canada, V5G 1T4
The Medical Arts Health Research Group
Penticton, British Columbia, Canada, V2A5G8
LMC Clinical Research dba Manna Research Inc. Vancouver
Vancouver, British Columbia, Canada, V6J 1S3
Fraser Clinical Trials Inc.
Victoria, British Columbia, Canada, V8R 4R2
Discovery Clinical Services Ltd.
Victoria, British Columbia, Canada, V8T 5G4
CookMed Research
Victoria, British Columbia, Canada, V8V 4A1
Canada, Manitoba
Winnipeg Regional Health Authority, Winnipeg
Winnipeg, Manitoba, Canada, R3E 3P4
Canada, Nova Scotia
True North Clinical Research Halifax, Inc.
Halifax, Nova Scotia, Canada, B3S 1M7
Canada, Ontario
LMC Endocrinology Centres (Barrie) Ltd.
Barrie, Ontario, Canada, L4N 7L3
JBN Medical Diagnostic Services Inc.
Burlington, Ontario, Canada, L7M 4Y1
LMC Endocrinology Centres (Etobicoke) Ltd.
Etobicoke, Ontario, Canada, M9R 4E1
LMC Endocrinology Centres (Markham) Ltd.
Markham, Ontario, Canada, L6B 0P9
SKDS Research Incorporated
Newmarket, Ontario, Canada, L3Y 5G8
Medicor Research
Sudbury, Ontario, Canada, P3E 1H5
Sudbury Cardiac Research
Sudbury, Ontario, Canada, P3E 2N8
Dr. R. Labonte Prof. Med. Corp
Sudbury, Ontario, Canada, P3E 3B8
Canada, Quebec
ViaCar Recherche Clinique Inc
Brossard, Quebec, Canada, J4Z 2K9
Hopital Charles - LeMoyne
Greenfield Park, Quebec, Canada, J4V 2G9
Centre De Recherche Clinique
Laval, Quebec, Canada, H7T 2P5
Recherche Invascor Inc.
Longueuil, Quebec, Canada, J4N 1C2
Centre Hospitalier de l'Universite de Montreal (CHUM)
Montreal, Quebec, Canada, H2X 0A9
McGill University Health Centre (MUHC)
Montreal, Quebec, Canada, H4A 3J1
St Jerome Medical Research Inc.
St-Jerome, Quebec, Canada, J7Z 5T3
LMC Endocrinology Centres (Montreal)
Ville Saint-Laurent, Quebec, Canada, H4T 1Z9
Recherche Clinique Sigma Inc.
Quebec, Canada, G1G 3Y8
Clinique des maladies Lipidiques de Quebec
Quebec, Canada, G1V 4M6
Hospital Regional de Punta Arenas Dr. Lautaro Navarro Avaria
Punta Arenas, Chile, 6200000
Hospital El Pino
Santiago, Chile, 0
Sociedad Medica Cardiologica El Llano
Santiago, Chile, 0
Hospital Militar de Santiago
Santiago, Chile, 7850000
Hospital Sotero del Rio
Santiago, Chile, 8150000
CeCim - Centro de Estudios Clinicos e Investigacion Medica
Santiago, Chile, 8331143
Hospital Padre Alberto Hurtado
Santiago, Chile, 8880465
Hospital Base Valdivia
Valdivia, Chile, 5090000
Hospital Naval Almirante Nef
Viña del Mar, Chile, 2520000
Beijing Jishuitan Hospital
Beijing, China, 100035
Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China, 510150
Zhejiang University School of Medicine SIR RUN RUN SHAW Hospital
Hangzhou, China, 310016
Center Hospital of Jinan
Jinan, China, 250013
People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, China, 530021
Tongji Hospital, Tongji University
Shanghai, China, 200065
First Affiliated Hospital of Xi'an JiaoTong University
Xi'an, China, 710061
General Hospital of Ningxia Medical University
Yinchuan, China, 750004
Armenia, Colombia, 55860
Corazon IPS S.A.S.
Barranquilla, Colombia, 0000
Clínica de la Costa Ltda.
Barranquilla, Colombia, 0
IPS Centro Cientifico Asistencia
Barranquilla, Colombia, 80020
Centro de Atencion e Investigacion Medica S.A. - CAIMED
Bogota, Colombia, 0
CAFESALUD Medicina Prepagada S.A.
Bogota, Colombia, 110221
Solano y Terront Servicios Médicos Ltda.
Bogota, Colombia, 110221
Dexa Diabetes Servicios Médicos Ltda
Bogotá, Colombia, 110221
Fundacion Reina Isabel
Cali, Colombia, 0
IPS Centro Medico Julián Coronel S.A.
Cali, Colombia, 0
Fundación Centro de Investigaciones Biomédicas Riescard
Espinal, Colombia, 0
Centro de Investigacion Clínica Avanzada
Medellin, Colombia, 0
Fundacion Centro de Investigacion Clinica CIC, Medellin
Medellin, Colombia, 50021
Fundacion Centro de Obesidad y Metabolismo - COMETA
Pasto, Colombia, 52002
Healthy Medical CenterS.A.S, Zipaquirá
Zipaquirá, Colombia, 0
General Hospital Karlovac
Karlovac, Croatia, 47000
Hospital for Medical Rehabilitation, Krapinske Toplice
Krapinske Toplice, Croatia, 49217
General Hospital Slavonski Brod
Slavonski Brod, Croatia, 35000
General Hospital Varazdin
Varazdin, Croatia, 42000
General Hosp. Zadar, Dept. of Internal Medicine-Pulmonology
Zadar, Croatia, 23000
Clinical Hospital Sveti Duh
Zagreb, Croatia, 10000
University hospital center Zagreb
Zagreb, Croatia, 10000
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia, 656 91
Fakultni nemocnice u sv. Anny v Brne
Brno, Czechia, 65691
Revmatologie Bruntal, s.r.o.
Bruntal, Czechia, 792 01
Poliklinika Chocen, a.s.
Chocen, Czechia, 56501
Aesculap Ambulance Sro
Dolni Brezany, Czechia, 252 41
OKELI s.r.o.
Hodonin, Czechia, 695 01
Nemocnice Jindrichuv Hradec a.s.
Jindrichuv Hradec, Czechia, 377 01
Regional Hospital Liberec
Liberec, Czechia, 460 63
InterKardioML s.r.o.
Marianske Lazne, Czechia, 353 01
Interna a diabetologicka ordinace s.r.o.
Nachod, Czechia, 547 01
PreventaMed, s.r.o.
Olomouc, Czechia, 77900
Univ. Hospital Kralovske Vinohrady
Praha 10, Czechia, 100 34
Vseobecna fakultni nemocnice V Praze
Praha 2, Czechia, 128 08
Thomayer Hospital
Praha 4 - Krc, Czechia, 140 59
ResTrial s.r.o.
Praha 8, Czechia, 181 00
Hospital Slany, Internal Department
Slany, Czechia, 274 01
Krajska zdravotni, a.s. - Nemocnice Teplice, o.z.
Teplice, Czechia, 41501
Studienzentrum Aschaffenburg
Aschaffenburg, Germany, 63739
Zentrum für klinische Forschung Dr. med. Irma Schöll & Kollegen
Bad Homburg, Germany, 61348
Universitätsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 1307
IKF Pneumologie GmbH & Co. KG
Frankfurt am Main, Germany, 60596
ClinPhenomics GmbH & Co KG, Frankfurt
Frankfurt, Germany, 60594
Diabetologische Schwerpunktpraxis, Hohenmölsen
Hohenmölsen, Germany, 6679
EUGASTRO GmbH, Leipzig
Leipzig, Germany, 4103
Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut, Leipzig
Leipzig, Germany, 4249
Lausmed Kft. Outpatient Unit of Internal Medicine
Baja, Hungary, 6500
Dr. Kenessey Albert Kórház-Rendelõintézet, Balassagyarmat
Balassagyarmat, Hungary, 2660
DRC Gyogyszervizsgalo Kozpont Kft., Balatonfured
Balatonfured, Hungary, 8230
Clinexpert Kft.
Budapest, Hungary, 1033
Obudai Egeszsegugyi Centrum
Budapest, Hungary, 1036
Budapest, Hungary, 1036
Semmelweis Egyetem, Budapest
Budapest, Hungary, 1083
Semmelweis Egyetem, Budapest
Budapest, Hungary, 1088
Semmelweis Egyetem, Budapest
Budapest, Hungary, 1125
University Debrecen Hospital
Debrecen, Hungary, 4032
Markhot Ferenc Hospital, Eger
Eger, Hungary, 3300
Csongrad Megyei Eu. Ellato Kozp. Hodmezovasarhely-Mako
Hodmezovasarhely, Hungary, 6800
Somogy Megyei Kaposi Mor Oktato Korhaz, Kaposvar
Kaposvar, Hungary, 7400
Selye Janos Hospital Komarom
Komarom, Hungary, 2900
Ermellek Egeszsegcentrum
Letavertes, Hungary, 4281
Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
Miskolc, Hungary, 3526
Pecsi Tudomanyegyetem
Pecs, Hungary, 7624
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klin. Kozpont
Szeged, Hungary, 6725
Zala Megyei Szent Rafael Korhaz
Zalaegerszeg, Hungary, 8900
Haemek Medical Center
Afula, Israel, 18101
Bnei Zion Medical Center, Haifa
Haifa, Israel, 31048
Rambam Medical Center
Haifa, Israel, 3109601
Herzliya Medical Center
Herzliya, Israel, 4685107
Wolfson Medical Center
Holon, Israel, 58100
Hadassah Medical Center, Ein-Karem
Jerusalem, Israel, 9112001
Meir Medical Center
Kfar-Saba, Israel, 4428164
Galilee Medical Center
Nahariya, Israel, 2210001
Ziv Medical Center
Safed, Israel, 13100
Sourasky Medical Center
Tel Aviv, Israel, 6423906
Daishinkai Medical Corporation Ookuma Hospital
Aichi, Nagoya, Japan, 462-0825
Seikeikai New Tokyo Heart Clinic
Chiba, Matsudo, Japan, 271-0077
Saiseikai Matsuyama Hospital
Ehime, Matsuyama, Japan, 791-8026
Aso Co.,Ltd Iizuka Hospital
Fukuoka, Iizuka, Japan, 820-8505
Kitakyushubyoin Kitakyushu General Hospital
Fukuoka, Kitakyushu, Japan, 800-0295
The Veritas Hospital
Hyogo, Kawanishi, Japan, 666-0125
Ibaraki Seinan Medical Center Hospital
Ibaraki, Sashima-gun, Japan, 306-0433
Kokan Clinic
Kanagawa, Kawasaki, Japan, 210-0852
Nagano Red Cross Hospital
Nagano, Nagano, Japan, 380-8582
Josuikai Olive Takamatsu Medical Clinic
Takamatsu-shi, Japan, 760-0076
Korea, Republic of
Hallym University Sacred Heart Hospital
Anyang-si, Korea, Republic of, 431-070
Inje University Busan Paik Hospital
Busan, Korea, Republic of, 47392
Dong-A University Hospital
Busan, Korea, Republic of, 602-715
Pusan National Univ. Hosp
Busan, Korea, Republic of, 602-739
Myongji Hospital
Goyang-si, Korea, Republic of, 412-270
Gachon University Gil Medical Center
Incheon, Korea, Republic of, 21565
The Catholic University of Korea, Seoul St.Mary's Hospital
Seoul, Korea, Republic of, 06591
Seoul National University Hospital
Seoul, Korea, Republic of, 110744
Asan Medical Center
Seoul, Korea, Republic of, 138736
Korea University Anam Hospital
Seoul, Korea, Republic of, 2841
Korea University Guro Hospital
Seoul, Korea, Republic of, 8308
Wonju Severance Christian Hosp
Wonju, Korea, Republic of, 26426
Hospital Sultanah Bahiyah
Alor Setar, Malaysia, 5460
Hospital Tengku Ampuan Rahimah
Klang, Malaysia, 41200
University Malaya Medical Centre
Kuala Lumpur, Malaysia, 59100
Hospital Tengku Ampuan Afzan
Kuantan, Malaysia, 25100
Monash University(Sunway Campus)
Petaling Jaya, Malaysia, 46150
Hospital Pulau Pinang
Pulau Pinang, Malaysia, 10450
Universiti Putra Malaysia
Serdang, Malaysia, 43400
Hospital Seri Manjung
Seri Manjung, Malaysia, 32040
Hospital Taiping
Taiping, Malaysia, 34000
Klinik Kesihatan Tampin
Tampin, Malaysia, 73009
Investigación en Salud y Metabolismo S.C.
Chihuahua, Mexico, 31237
Phylasis Clinicas Research S de RL de CV
Cuautitlan Izcalli, Mexico, 54769
Centro para el Desarrollo de la Medicina y de Asist Med Espe
Culiacan, Mexico, CP80020
Centro de Investigacion Biomedica y Farmaceutica, S.C.
Distrito Federal, Mexico, 03100
Servicios Medicos de la Pena SC
Guadalajara, Mexico, 44690
Medical Care & Research SA de CV
Merida, Mexico, 97070
Sociedad de Cirugia Vascular Plastica Reconstructiva
Merida, Mexico, 97129
Phytomedicamenta S.A. de C.V.
Mexico, Mexico, 03100
Comite Mexicano Para la Prevencion de Osteoporosis AC
Mexico, Mexico, 06100
Centro de Atención e Investigación en Factores de Riesgo
Mexico, Mexico, 06700
Clinstile S.A. de C.V.
Mexico, Mexico, 06700
Ultimate Medica SA de CV
Mexico, Mexico, 11850
Health Pharma Professional Research S.A. de C.V.
Mexico, Mexico, 3810
Centro de Estudios Clinicos y Especialidades Medicas, S.C.
Monterrey, Mexico, 64620
AVIX Investigación Clínica S.C
Monterrey, Mexico, 64710
Global Trial Research Center S.A. de C.V.
Monterrey, Mexico, 64718
Centro de Investigacion Clinica Chapultepec S. A. de C. V.
Morelia, Mexico, 58260
Centro de Estudios Clínicos de Queretaro S.C., CECLIQ
Queretaro, Mexico, 76000
Centro de Investigacion Cardiovascular y Metabolica
Tijuana, Mexico, 22500
Centro de Investigación Médica de Ocidente, S.C.
Zapopan, Mexico, 45116
Hospital Dr Angel Leano
Zapopan, Mexico, 45200
Rijnstate Hospital
Arnhem, Netherlands, 6815 AD
Albert SchweitzerZiekenhuis
Dordrecht, Netherlands, 3318 AT
Universitair Medisch Centrum Groningen
Groningen, Netherlands, 9713 GZ
Martini Ziekenhuis
Groningen, Netherlands, 9728 NT
Bethesda Cardiology Group, Hoogeveen
Hoogeveen, Netherlands, 7909 AA
Maastricht Universitair Medisch Centrum
Maastricht, Netherlands, 6229 HX
Rotterdam Research Institute
Rotterdam, Netherlands, 3039 BD
Universitair Medisch Centrum Utrecht
Utrecht, Netherlands, 3584 CX
TweeSteden Ziekenhuis
Waalwijk, Netherlands, 5141 BM
Gelre Ziekenhuis Zutphen
Zutphen, Netherlands, 7207 BA
B_Serwis Popenda Sp.Jawna
Chorzow, Poland, 41-500
Poradnia Kardiologiczna Jaroslaw Jurowiecki
Gdansk, Poland, 80-286
University Clinical Center, Gdansk
Gdansk, Poland, 80-952
Indywidualna Specjalistyczna Praktyka Lekarska
Gdynia, Poland, 81-157
MCBK Iwona Czajkowska Anna Podrazka- Szczepaniak S.C.
Grodzisk Mazowiecki, Poland, 05-825
Centrum Medyczne Pratia Katowice II
Katowice, Poland, 40-084
Polimedica Centrum Bada?, Profilaktyki I Leczenia
Kielce, Poland, 25-364
NZOZ Centrum Medyczne ProMiMed Sp. z o.o., Sp.k., Krakow
Krakow, Poland, 31-637
Centrum Terapii Wspolczesnej J.M.
Lodz, Poland, 90-242
CCBR - Lodz - PL, Lodz
Lodz, Poland, 90-368
Individual Specialized Practice
Lodz, Poland, 94-255
Centrum Medyczne "Luxmed" Sp. z o.o.
Lublin, Poland, 20-109
KO-MED Centra Kliniczne Lublin II
Lublin, Poland, 20-362
NZOZ Specialized Ambulance "MEDICA"
Lublin, Poland, 20-538
RCMed- Regionalne Centrum Medyczne
Nowy Duninow, Poland, 09-505
Medicome Sp. z o.o.
Oswiecim, Poland, 32-600
Prywatny Gabinet Lekarski Lech Lazuka
Parczew, Poland, 21-200
Clin.Hosp.Med.Univ.Marcinkowski in Poznan
Poznan, Poland, 60-569
Praktyka Lekarska Ewa Krzyzagorska
Poznan, Poland, 61-655
KOMED Marek Konieczny
Pulawy, Poland, 24-100
Indywidualna Specjalistyczna Praktyka Lekarska Dr N Med Andrzej Wittek
Ruda Slaska, Poland, 41-709
Centrum Medyczne Medyk
Rzeszow, Poland, 35-055
RCMed- Regionalne Centrum Medyczne
Sochaczew, Poland, 96-500
NSZOZ Medicus
Sroda Wielkopolska, Poland, 63-000
KO-MED Centra Kliniczne Staszow
Staszow, Poland, 28-200
Lecznice Citomed Sp. z o.o.
Torun, Poland, 87-100
NZOZ Nasz Lekarz
Torun, Poland, 87-100
NBR Polska
Warsaw, Poland, 00-465
CCBR/Somed - Warszaw - PL
Warszaw, Poland, 04-730
Regionalna Poradnia Diabetoloiczna Zytkiewicz-Jaruga
Wroclaw, Poland, 50-127
KO-MED Centra Kliniczne Zamosc
Zamosc, Poland, 22-400
Polimedica Centrum Bada?, Profilaktyki I Leczenia
Zgierz, Poland, 95-100
Hospital de Braga-Escala Braga
Braga, Portugal, 4710-243
CHUC - Centro Hospitalar e Universitário de Coimbra, EPE
Coimbra, Portugal, 3000-075
APDP - Associação Protectora dos Diabéticos de Portugal
Lisboa, Portugal, 1250-203
CHLO, EPE - Hospital S. Francisco Xavier
Lisboa, Portugal, 1449-005
Hospital da Luz
Lisboa, Portugal, 1500-650
Hospital CUF Porto
Porto, Portugal, 4100-180
Centro Hospitalar de Vila Nova de Gaia
V. N. Gaia, Portugal, 4434-502
SC Diana Barbonta SRL, Alba Iulia
Alba Iulia, Romania, 510053
Spitalul Universitar de Urgenta, Bucuresti
Bucuresti, Romania, 010825
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
Bucuresti, Romania, 011234
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul Central
Bucuresti, Romania, 020475
CMI Dr. Stolea T. Violeta
Bucuresti, Romania, 061072
Clinica Medicala Data Plus SRL
Bucuresti, Romania, 10192
I.N.D.N.B.M. "Prof. Dr. N.C. Paulescu" - Sediul "I.L. Caragiale"
Bucuresti, Romania, 20045
S.C Centrul Medical "Sanatatea Ta" S.R.L
Bucuresti, Romania, 20614
S.C. Policlinica CCBR SRL, Bucuresti
Bucuresti, Romania, 30463
Medcon SRL
Buzau, Romania, 120203
Spitalul Clinic Judetean de Urgenta ¿Sf. Apostol Andrei¿
Galati, Romania, 800578
Spitalul Clinic, Iasi
Iasi, Romania, 700503
Consultmed SRL, Iasi
Iasi, Romania, 700547
SC Diaconu-Sotropa Michaela, Cabinet de Diabet
Iasi, Romania, 700613
S.C Grandmed S.R.L, Oradea
Oradea, Romania, 410159
Pelican Impex SRL, Cabinet Nr. 15
Oradea, Romania, 410469
S.C Anamed S.R.L
Oradea, Romania, 410491
S.C. Diabmed Dr. Popescu Alexandrina S.R.L
Ploiesti, Romania, 100163
Gensan SRL
Sibiu, Romania, 550371
Centrul Medical Dr Negrisanu SRL
Timisoara, Romania, 300456
Mediab SRL
Tirgu Mures, Romania, 540142
Russian Federation
SBEI HPE Altay State Medical University of MoH and SD
Barnaul, Russian Federation, 656038
Kemerovo, Russian Federation, 650002
NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"
Kemerovo, Russian Federation, 650055
First Moscow State Medical University n.a. I.M. Sechenov
Moscow, Russian Federation, 119435
Moscow 1st State Med.Univ.n.a.I.M.Sechenov
Moscow, Russian Federation, 119992
SBEI HPE "Moscow State Medical and Dentistry University
Moscow, Russian Federation, 127473
Moscow State Medical Dentistry University
Moscow, Russian Federation, 129301
SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"
Novosibirsk, Russian Federation, 630008
Novosibirsk Regional Clinical Cardiological Dispansary
Novosibirsk, Russian Federation, 630047
FSBSI "Scientific Research Institute", Novosibirsk
Novosibirsk, Russian Federation, 630089
FSBSI "Scientific and Research Institute of Physiology and Basic Medicine"
Novosibirsk, Russian Federation, 630117
BIH of OR "City Hospital # 2", Omsk
Omsk, Russian Federation, 644021
SBIH of Perm territory " City Clinical Hospital # 2 n.a.
Perm, Russian Federation, 614068
SBI of Ryazan region "Regional Clinical Cardiological Dis.
Ryazan, Russian Federation, 390026
FSBMEI HPE "Military Medical Academy n.a. S.M. Kirov"
Saint-Petersburg, Russian Federation, 194044
1stPavlov St.Med.Univ.St.-Petersburg Res.Inst.
Saint-Petersburg, Russian Federation, 197022
Federal North-West Medical Research Centre
Saint-Petersburg, Russian Federation, 197341
SPb SBHI "City Policlinic #74"
Saint-Petersburg, Russian Federation, 197762
SPb SBIH "City Pokrovskaya Hospital"
Saint-Petersburg, Russian Federation, 199106
GUZ "City Clinical Hospital #40, 197706 Saint-Petersburg
Sestroretsk, Russian Federation, 197706
Medical Research Institute LLC, St. Petersburg
St. Petersburg, Russian Federation, 196084
FSBI "Research Institute for Cardiology"
Tomsk, Russian Federation, 634012
South Africa
Cardiology Clinical Research
Alberton, South Africa, 1449
Iatros International
Bloemfontein, South Africa, 9301
Limaro Research
Bloemfontein, South Africa, 9301
Dr JM Engelbrecht Practice
Cape Town, South Africa, 7129
Dr Dawood, Mohamed and Pillay
Cape Town, South Africa, 7405
TREAD Research
Cape Town, South Africa, 7500
Langeberg Clinical Trials
Cape Town, South Africa, 7570
Cape Town Medical Research Centre
Cape Town, South Africa, 7580
Ismail, SM
Cape Town, South Africa, 7764
Groote Schuur Hospital
Cape Town, South Africa, 7925
Latiff, GHVM
Durban, South Africa, 4001
Londisizwe Research Centre, Durban
Durban, South Africa, 4001
Diabetes Care Centre
Johannesburg, South Africa, 1501
Wits Clinical Research Chris Hani Baragwanath Hospital
Johannesburg, South Africa, 2013
WCR CMJAH Clinical Trial Site
Johannesburg, South Africa, 2193
DJW Navorsing
Krugersdorp, South Africa, 1739
Emmed Research
Pretoria, South Africa, 0002
University of Pretoria
Pretoria, South Africa, 0002
Syzygy Clinical Research Services
Pretoria, South Africa, 0087
Into Research
Pretoria, South Africa, 181
Seeber, M
Pretoria, South Africa, 2
Dr M Duki Research and Trial Site, Verulam
Verulam, South Africa, 4339
Clinical Projects Research
Worcester, South Africa, 6850
Hospital Virgen del Mar
Almeria, Spain, 04120
Hospital de la Ribera
Alzira, Spain, 46600
Hospital Germans Trias i Pujol
Badalona, Spain, 08916
Barcelona, Spain, 08006
CAP Sarria
Barcelona, Spain, 08017
Hospital Quiron. I.C.U.
Barcelona, Spain, 08023
EBA Centelles
Centelles, Spain, 08540
Fundación Jiménez Díaz
Madrid, Spain, 28040
Hospital Regional Universitario de Málaga
Malaga, Spain, 29010
Hospital General de Segovia
Segovia, Spain, 40002
Hospital Quironsalud Infanta Luisa
Sevilla, Spain, 41010
Hospital Virgen Macarena
Sevilla, Spain, 41071
Hospital General Universitario de Valencia
Valencia, Spain, 46014
Hospital Dr. Peset
Valencia, Spain, 46017
Hospital Virgen de las Montañas, Villamartin
Villamartin, Spain, 11650
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung, Taiwan, 807
Kaohsiung Veterans General Hospital
Kaohsiung, Taiwan, 81362
Far Eastern Memorial Hospital
New Taipei City, Taiwan, 220
China Medical University Hospital
Taichung, Taiwan, 404
Tainan, Taiwan, 704
National Taiwan University Hospital
Taipei, Taiwan, 100
Taipe Veterans General Hospital
Taipei, Taiwan, 11217
Chang-Gung Memorial Hospital, Linkou
Taoyuan County, Taiwan, 333
Chernivtsi Regional Endocrinology Dispensary
Chernivtsi, Ukraine, 58022
Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU
Ivano-Frankivsk, Ukraine, 76008
CI Ivano-Frankivsk Reg Cl Card Center
Ivano-Frankivsk, Ukraine, 76018
L.T. Malaya Institute of Therapy AMS of Ukraine
Kharkiv, Ukraine, 61039
CIPH Prof. O.I. Meshchaninov Kharkiv CCH of A&E
Kharkiv, Ukraine, 61103
CI of Healthcare Kharkiv CCH #8, Kharkiv
Kharkiv, Ukraine, 61176
KCCC of Endocr Dept of General Endocrine Pathology
Kyiv, Ukraine, 01004
City Clinical Hospital No. 1, Kiev
Kyiv, Ukraine, 02091
V.P. Komisarenko Inst. of Endocrinology and Metabolism
Kyiv, Ukraine, 04114
Kjiv City Oleksandrivska Clinical Hospital
Kyiv, Ukraine, 1601
LLC Treatment and Diagnostic Center Adonis Plus, Kyiv
Kyiv, Ukraine, 2002
SI National Scientific Centre of Radiation Medicine of NAMSU
Kyiv, Ukraine, 3115
P.L. Shupyk NMA of PGE Ch of D H for S-ts of NASU
Kyiv, Ukraine, 4050
SI V.P.Komisarenko Institute of Endocrinology and Metabolism
Kyiv, Ukraine, 4114
Lviv Regional Endocrinology Dispensary
Lviv, Ukraine, 79010
M.V. Sklifosovskyi Poltava RCH, Poltava
Poltava, Ukraine, 36011
CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU
Sumy, Ukraine, 40021
CI of TRC Ternopil UH
Ternopli, Ukraine, 46002
Private Small Enterprise Medical Center Pulse
Vinnytsia, Ukraine, 21001
Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy
Vinnytsia, Ukraine, 21010
M.I. Pyrogov VRCH, Vinnytsia
Vinnytsia, Ukraine, 21018
CCH #1 M.I. Pyrogov VNMU Ch of Propaedeutics of IM
Vinnytsia, Ukraine, 21021
CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin
Zaporizhzhia, Ukraine, 69001
United Kingdom
University Hospital Monklands
Airdrie, United Kingdom, ML6 0JS
Queen Elizabeth Hospital
Birmingham, United Kingdom, B15 2TH
Bradford on Avon Health Centre
Bradford on Avon, United Kingdom, BA15 1DQ
Ashgate Medical Practice
Chesterfield, United Kingdom, S40 4AA
Dumfries and Galloway Royal Infirmary
Dumfries, United Kingdom, DG1 4AP
Ninewells Hospital & Medical School
Dundee, United Kingdom, DD1 9SY
Royal Devon and Exeter Hospital
Exeter, United Kingdom, EX2 5DW
Glasgow Royal Infirmary
Glasgow, United Kingdom, G4 0SF
Leicester General Hospital
Leicester, United Kingdom, LE5 4PW
Barts and The London School of Medicine and Dentistry
London, United Kingdom, EC1M 6BQ
Morriston Hospital
Swansea, United Kingdom, SA6 6NL
Queen Elizabeth II Hospital
Welwyn Garden City, United Kingdom, AL7 4HQ
New Cross Hospital
Wolverhampton, United Kingdom, WV10 0QP
Sponsors and Collaborators
Boehringer Ingelheim
Eli Lilly and Company
Layout table for investigator information
Study Chair: Boehringer Ingelheim Boehringer Ingelheim
  Study Documents (Full-Text)

Documents provided by Boehringer Ingelheim:
Study Protocol  [PDF] November 22, 2016
Statistical Analysis Plan  [PDF] December 18, 2017

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):

Layout table for additonal information
Responsible Party: Boehringer Ingelheim Identifier: NCT01897532     History of Changes
Other Study ID Numbers: 1218.22
2011-004148-23 ( EudraCT Number )
First Posted: July 12, 2013    Key Record Dates
Results First Posted: January 25, 2019
Last Update Posted: April 4, 2019
Last Verified: March 2019
Additional relevant MeSH terms:
Layout table for MeSH terms
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Dipeptidyl-Peptidase IV Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action