Comparison of Aortic Root Dimension Changes During Cardiac Cycle Between the Patients With and Without Aortic Valve Calcification Using ECG-gated 64-slice and Dual-source 256-slice Computed Tomography Scanners: Results of a Multicenter Study
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ClinicalTrials.gov Identifier: NCT01755806 |
Recruitment Status :
Completed
First Posted : December 24, 2012
Last Update Posted : December 24, 2012
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Condition or disease |
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Aortic Valve Calcification |
Study Type : | Observational |
Actual Enrollment : | 104 participants |
Observational Model: | Case-Control |
Time Perspective: | Retrospective |
Study Start Date : | January 2012 |
Actual Primary Completion Date : | November 2012 |
Actual Study Completion Date : | December 2012 |

Group/Cohort |
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aortic root dimension change
those without aortic valve calcification
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aortic root dimension change, aortic valve calcium score
those with aortic valve calcification
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- Evidence of aortic root dimension change confirmed by multislice CT in systolic phase (30% of R-R interval) compared to diastolic phase (70% of R-R interval) after retrospective ECG gating [ Time Frame: during a few heat beat (8 to 13 seconds) ]Detailed information about aortic root dimension changes during cardiac cycle has become of utmost interest especially after introduction of transcatheter aortic valve implantation (TAVI) as an alternative therapeutic procedure in patients with severe aortic stenosis, in that paravalvular regurgitation and procedural failure will ensue from errors in selecting the appropriate prosthesis size

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Ages Eligible for Study: | 20 Years to 90 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- Patients referring for multislice coronary computed tomography for any reason
Exclusion Criteria:
- Arrhythmia
- Hypertrophic cardiomyopathy
- Aneurysm formation of ascending aorta
- Marfan's disease
- Ehlers-Danlos syndrome
- History of coronary artery bypass surgery
- History of coronary stenting
- Aortic valve surgery
- Thoracic aorta surgery
- Aortic valve stenosis

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01755806
Iran, Islamic Republic of | |
Modarres Hospital | |
Tehran, Iran, Islamic Republic of, 19998734383 | |
Day General Hospital | |
Tehran, Iran, Islamic Republic of | |
Rajaie Cardiovascular medical and Research Center | |
Tehran, Iran, Islamic Republic of |
Responsible Party: | Modarres Hospital |
ClinicalTrials.gov Identifier: | NCT01755806 |
Other Study ID Numbers: |
ModarresH_001 |
First Posted: | December 24, 2012 Key Record Dates |
Last Update Posted: | December 24, 2012 |
Last Verified: | December 2012 |
Aortic annulus Aortic calcification Multislice computed tomography Cardiac cycle |
Aortic Valve Stenosis Calcinosis Calcium Metabolism Disorders Metabolic Diseases |
Heart Valve Diseases Heart Diseases Cardiovascular Diseases Ventricular Outflow Obstruction |