Genetic and Neural Predictors of Adolescent Depression
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01743716 |
Recruitment Status :
Active, not recruiting
First Posted : December 6, 2012
Last Update Posted : February 25, 2020
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Condition or disease |
---|
Major Depressive Disorder |
Study Type : | Observational |
Estimated Enrollment : | 100 participants |
Observational Model: | Other |
Time Perspective: | Cross-Sectional |
Official Title: | Towards Identification of Genetic and Neural Predictors of Adolescent Depression |
Actual Study Start Date : | April 2013 |
Estimated Primary Completion Date : | December 2020 |
Estimated Study Completion Date : | December 2020 |

Group/Cohort |
---|
MDD Mothers
Adult women with a history of major depressive disorder (MDD) and a healthy adolescent daughter between the ages of 12-14
|
Healthy Control Mothers
Adult women with no history of psychopathology and an adolescent daughter between the ages of 12-14
|
High Risk Female Adolescents
Healthy female adolescents aged 12-14 with a mother in the MDD Mothers cohort
|
Healthy Female Adolescents
Healthy female adolescents aged 12-14 with a mother in the Healthy Control Mothers cohort.
|
- Neurobiological Activity in Frontostriatal and Mesolimbic Regions [ Time Frame: Baseline ]
- Depressive Symptoms [ Time Frame: 6 months ]
Biospecimen Retention: Samples With DNA

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 12 Years and older (Child, Adult, Older Adult) |
Sexes Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Adult Cohort
A. MDD Mothers Cohort Inclusion Criteria:
- Current or past Major Depressive Disorder
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for High Risk Female Adolescent
B. Healthy Control Mothers Cohort Inclusion Criteria:
- No history of psychopathology
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for Healthy Female Adolescent
Adolescent Cohort
General Inclusion Criteria for Adolescent Cohorts:
- Female
- Ages 12-14
- English as first language or English fluency
- Right handed
General Exclusion Criteria for Adolescent Cohorts:
- Past or present diagnosis of Major Depressive Disorder
- Past or present diagnosis of any anxiety disorder
- Past or present diagnosis of Bipolar Disorder
- Past or present diagnosis of ADHD
- Presence of medical or neurological illness (head injury, loss of consciousness greater than 5 minutes, seizure)
- Current use of psychotropic medication
-
Presence of any contraindication for MRI:
- Cardiac pacemakers
- Metal clips on blood vessels (also called stents)
- Artificial heart valve, artificial arms, hands, legs, etc.
- Brain stimulator devices
- Implanted drug pumps
- Ear or eye implants
- Known metal fragments in eyes
- Exposure to metal filings or shrapnel (sheet metal workers, welders, and others)
- Other metallic surgical hardware in vital area
- Certain tattoos with metallic ink
- Certain IUDs containing metal
- Certain transdermal (skin) patches such as:
- NicoDerm (nicotine for tobacco dependence)
- Transderm Scop (scopolamine for motion sickness)
-
Ortho Evra (birth control)
- Positive urine pregnancy test
C. High Risk Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the MDD Mothers cohort
D. Healthy Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the Healthy Control Mothers cohort

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01743716
United States, Massachusetts | |
McLean Hospital | |
Belmont, Massachusetts, United States, 02478 |
Principal Investigator: | Randy P. Auerbach, PhD | Mclean Hospital | |
Principal Investigator: | Diego A. Pizzagalli, PhD | Mclean Hospital |
Responsible Party: | Randy P. Auerbach, Principal Investigator, Mclean Hospital |
ClinicalTrials.gov Identifier: | NCT01743716 |
Other Study ID Numbers: |
2012P002351 |
First Posted: | December 6, 2012 Key Record Dates |
Last Update Posted: | February 25, 2020 |
Last Verified: | February 2020 |
Major Depressive Disorder MDD depression adolescent |
Depression Depressive Disorder Depressive Disorder, Major |
Behavioral Symptoms Mood Disorders Mental Disorders |