Bacterial Meningitis in Adults: Analysis of the Determinants of Mortality and Neurosensory Sequelae (COMBAT)
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|ClinicalTrials.gov Identifier: NCT01730690|
Recruitment Status : Completed
First Posted : November 21, 2012
Last Update Posted : July 5, 2017
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Major changes in the epidemiological characteristics of bacterial meningitis have been observed as a result of changes in behaviour, human interventions (use of antibiotics, prophylactic vaccinations), as well as poorly elucidated mechanisms responsible for epidemic outbreaks.
The objective of this study is to identify the determinants of in-hospital mortality of bacterial meningitis in adults.
Hypothesis : the standardized data collection concerning cases of bacterial meningitis in adults with telephone follow-up would allow analysis of the determinants of mortality and neurosensory sequelae, description of the psychosocial impact and proposal of new treatment strategies.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||527 participants|
|Official Title:||Bacterial Meningitis in Adults: Analysis of the Determinants of Mortality and Neurosensory Sequelae|
|Study Start Date :||March 2013|
|Actual Primary Completion Date :||June 2017|
|Actual Study Completion Date :||June 2017|
- In-hospital mortality [ Time Frame: 30 days ]mortality in hospital at 30 days
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|Ages Eligible for Study:||18 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
|Sampling Method:||Non-Probability Sample|
- Positive CSF culture and/or positive soluble antigens in CSF with or without a cell reaction
- Positive PCR in CSF
- Purpura fulminant (with or without positive CSF culture)
- Positive PCR in blood and/or positive blood culture AND CSF cell reaction.
- Age less than 18 years old
- Refusal to participate
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01730690
|Assistance Publique des Hôpitaux de Paris|
|Principal Investigator:||Xavier duval||APHP|
|Responsible Party:||Assistance Publique - Hôpitaux de Paris|
|Other Study ID Numbers:||
NI11046 ( Other Identifier: APHP )
|First Posted:||November 21, 2012 Key Record Dates|
|Last Update Posted:||July 5, 2017|
|Last Verified:||July 2017|
Bacterial meningitis in adults
determinants of in-hospital mortality
Central Nervous System Diseases
Nervous System Diseases
Central Nervous System Bacterial Infections
Bacterial Infections and Mycoses
Central Nervous System Infections