Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Study of Curcumin, Vorinostat, and Sorafenib

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01608139
Recruitment Status : Withdrawn
First Posted : May 30, 2012
Last Update Posted : October 19, 2012
Sponsor:
Collaborator:
Sabinsa Corporation
Information provided by (Responsible Party):
M.D. Anderson Cancer Center

Brief Summary:
The goal of this clinical research study is to learn the highest tolerable dose of the combination of curcumin, vorinostat, and sorafenib that can be given to patients with advanced solid cancer. The safety of this drug combination will also be studied.

Condition or disease Intervention/treatment Phase
Advanced Cancers Drug: Curcumin Drug: Sorafenib Drug: Vorinostat Phase 1

  Hide Detailed Description

Detailed Description:

The Study Drugs:

Curcumin is the active ingredient in the spice, turmeric. It is a natural anti-inflammatory compound and has shown anti-tumor activity in the laboratory and in clinical trials.

Vorinostat is designed to cause chemical changes in different kinds of proteins that are attached to DNA (the genetic material of cells), which may slow the growth of cancer cells or cause the cancer cells to die.

Sorafenib is designed to block the ability of important proteins to activate in cancer cells. These proteins, when active, are in part responsible for the abnormal growth and behavior of cancer cells. Blocking their activity may slow the growth of the cancer cells or cause the cancer cells to die.

Study Groups:

If you are found to be eligible to take part in this study, you will be assigned to a dose level of the study drug combination (curcumin, vorinostat, and sorafenib) based on when you joined this study. Up to 9 dose levels of the study drug combination will be tested.

Three (3) to 6 participants will be enrolled at each dose level of the study drug combination. The first group of participants will receive the lowest dose level of the study drug combination. Each new group will receive a higher dose of the study drug combination than the group before it, if no intolerable side effects were seen. This will continue until the highest tolerable dose of the study drug combination is found.

The dose of the study drug combination that you receive may be lowered if you experience any intolerable side effects. You will not receive any doses of the study drug combination higher than the dose level that you are first assigned.

Study Drug Administration:

For the purposes of this study, a study drug "cycle" is 28 days long.

Starting on Day 1 of Cycle 1, you will begin taking curcumin 1 time daily.

Starting on Day 3 of Cycle 1, you will being taking vorinostat 1 time daily.

Starting on Day 5 of Cycle 1, you will begin taking sorafenib 1-2 times daily depending on the dose level you are assigned to. From this day forward, you will continue to take the study drug combination every day of each cycle.

Curcumin is a powder that comes in a paper packet, and you will take it by mouth with a full glass of water (8 oz.). Vorinostat and sorafenib are capsules that you will take by mouth. Vorinostat should be taken with food. Sorafenib should be taken without food. The capsules should be swallowed whole. You should not break, chew, or open the capsules.

Baseline Tests:

The following tests and procedures will be performed within 7 days before the first dose of the study drug combination (Day 1 of Cycle 1):

  • You will have a physical exam, including measurement of your height, weight, and vital signs (blood pressure, breathing rate, heart rate, and temperature).
  • You will be asked how well you are able to perform the normal activities of daily living (a performance status).
  • Blood (about 2 teaspoons) will be drawn for routine tests.
  • Urine will be collected for routine tests.
  • You will have an echocardiogram (ECHO) to check your heart function.
  • Women who are able to become pregnant must have a negative blood (about 1 teaspoon) pregnancy test. In order to continue your participation in this study, the pregnancy test must be negative.

Study Visits:

Every week while you are receiving the study drug combination, blood (about 2 teaspoons) will be drawn for routine tests.

Before you begin each cycle, the following tests and procedures will be performed:

  • You will have a physical exam, including measurement of your weight and vital signs.
  • Your performance status will be recorded.
  • Blood (about 2 teaspoons) will be drawn for routine tests.
  • You will have an ECG.
  • Urine will be collected for routine tests.
  • You will be asked about any side effects you may be experiencing.

At the end of every 2 cycles (Cycles 2, 4, 6, and so on):

  • You will have a chest x-ray, CT, MRI, and/or PET scan to check the status of the disease. If the study doctor thinks it is more appropriate for you, additional types of scans not listed in this consent form may need to be performed. The study doctor will discuss these scans with you, and you may be asked to sign a separate consent form that will explain the details and risks of those scans.
  • If the study doctor thinks it is needed, blood (about 1 teaspoon) will be drawn to measure tumor markers.

Length of Study:

You may remain on study for as long as the study doctor thinks you are benefitting from the study drugs. You will be taken off study early if the disease gets worse, you experience intolerable side effects, or the study doctor thinks it is in your best interest.

End-of-Study Visit:

Within 30 days after your last dose of the study drug combination, you will come back to the hospital for an end-of-study visit and the following tests and procedures performed:

  • You will have a physical exam, including measurement of your weight and vital signs.
  • Your performance status will be recorded.
  • Blood (about 2 teaspoons) will be drawn for routine tests.
  • Urine will be collected for routine tests.
  • You will be asked about any side effects you may be experiencing.
  • If the study doctor thinks it is needed, you will have a chest x-ray, CT, MRI, and/or PET scan to check the status of the disease. If the study doctor thinks it is more appropriate for you, additional types of scans not listed in this consent form may need to be performed. The study doctor will discuss these scans with you, and you may be asked to sign a separate consent form that will explain the details and risks of those scans.
  • If the study doctor thinks it is needed, blood (about 1 teaspoon) will be drawn to measure tumor markers.

This is an investigational study. Curcumin is a commercially available substance, which is commonly used as a food additive. Curcumin is not FDA approved for the treatment of advanced solid cancer. At this time, curcumin is only being used in research. Vorinostat is FDA approved and commercially available for the treatment of T-cell lymphoma. Sorafenib is FDA approved and commercially available for the treatment of liver and renal cancer. At this time, the combination of curcumin, vorinostat, and sorafenib is only being used in research.

Up to 96 patients will take part in this study. All will be enrolled at M. D. Anderson.


Layout table for study information
Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 0 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Pilot Study of Curcumin, Vorinostat, and Sorafenib in Patients With Advanced Solid Tumors
Study Start Date : November 2012
Estimated Primary Completion Date : November 2022

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Curcumin + Sorafenib + Vorinostat

Participant assigned to a dose level of the study drug combination based on when joined this study. Up to 9 dose levels of the study drug combination will be tested. Three (3) to 6 participants will be enrolled at each dose level of the study drug combination. During first cycle only, Curcumin initiated on Day 1, Vorinostat on Day 3 and Sorafenib on Day 5. Beginning with Cycle 1 Day 5, all agents administered continuously. Cycle of therapy is 28 days.

Starting dose of Curcumin: 4 grams by mouth per day on Day 1. Starting dose of Sorafenib: 200 mg by mouth daily beginning on Day 5. Starting dose of Vorinostat: 100 mg by mouth daily beginning on Day 3.

Drug: Curcumin
Starting dose: 4 grams by mouth per day. During the first cycle only, Curcumin given on Day 1. Beginning with Cycle 1 Day 5, all agents will be administered continuously.

Drug: Sorafenib
Starting dose: 200 mg by mouth daily. During the first cycle only, Sorafenib given on Day 5. Beginning with Cycle 1 Day 5, all agents will be administered continuously.
Other Names:
  • Nexavar
  • Bay 43-9006

Drug: Vorinostat
Starting dose: 100 mg by mouth daily. During the first cycle only, Vorinostat given on Day 3. Beginning with Cycle 1 Day 5, all agents will be administered continuously.
Other Names:
  • SAHA
  • Suberoylanilide Hydroxamic Acid
  • MSK-390
  • Zolinza




Primary Outcome Measures :
  1. Maximum Tolerated Dose (MTD) [ Time Frame: 4 weeks ]
    Maximum tolerated dose (MTD) defined by dose limiting toxicities (DLTs) that occur in the first cycle. Hematological DLT defined as platelets less than 25,000/uL or bleeding associated with platelets less than 50,000/uL, ANC less than 500/uL for more than 7 days, neutropenic fever, hemoglobin less than 6.5 g/dL, or more than 14 days of delay in initiation of subsequent treatment because of inadequate hematological parameters. Nonhematological toxicities graded by using NCI CTCAE v4.0 toxicity criteria.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. Patients must have an advanced solid tumor that has either failed one or more prior therapies or where there is no established standard of care therapy.
  2. Patients must have Eastern Cooperative Oncology Group (ECOG) performance status 2 or better (0-2).
  3. Patients must have normal organ and marrow function as defined below: Absolute neutrophil count (ANC) > 1,500/uL; Platelets > 100,000/uL; Total bilirubin within normal limits (patients with Gilbert's syndrome must have total bilirubin < 3.0 mg/dL) and aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 x the institutional upper limit of normal (ULN); Creatinine </= 1.5 x ULN; Hemoglobin >/= 9.0 gm/dL; prothrombin time (PT)/ partial thromboplastin time (PTT) within normal limits
  4. Patients must be able to understand and be willing to sign an IRB-approved written informed consent document.
  5. Women of child-bearing potential (women who are not postmenopausal for at least one year or are not surgically sterile) and men must agree to use adequate contraception (e.g. barrier method) prior to study entry, for the duration of study participation, and for 30 days after the last dose.
  6. Patients must be 18 years of age or older since the safety and dosages of these study drugs has not been demonstrated in the pediatric population. However, patients who are 13 years old or older and have more than 50 kg of body weight will be eligible after consultation with their pediatric attending.

Exclusion Criteria:

  1. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure (New York Heart Association (NYHA) Class III or IV), unstable angina pectoris, symptomatic cardiac arrhythmia, active bleeding, active thrombosis, or psychiatric illness/social situations that would limit compliance with study requirements.
  2. Inadequately controlled hypertension (defined as systolic blood pressure > 140 and/or diastolic blood pressure > 90 mmHg on antihypertensive medications), any prior history of hypertensive crisis or hypertensive encephalopathy, and history of myocardial infarction or unstable angina within 6 months prior to study enrollment.
  3. History of stroke or transient ischemic attack within 6 months prior to study enrollment and significant vascular disease (e.g., aortic aneurysm, aortic dissection) and symptomatic peripheral vascular disease.
  4. Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to study enrollment or anticipation of need for major surgical procedure during the course of the study. Minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to study enrollment.
  5. History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, or GI bleeding within 6 months prior to study enrollment; or serious, non-healing wound, ulcer, or bone fracture. Patients who have had a history of acute diverticulitis, GI obstruction, abdominal carcinomatosis, or peptic ulcer disease (known risks for bowel perforation) confirmed by endoscopy within the past 6 months, will also be excluded.
  6. Patients on therapeutic warfarin with history of deep vein thrombosis and/or pulmonary embolism.
  7. History of allergic reactions to the study drugs or their analogs.
  8. Patients that have had any treatment specific for tumor control within 3 weeks of study drug treatment or: a. within 2 weeks if cytotoxic agents were given weekly b. within 6 weeks for nitrosoureas or mitomycin C c. within 4 half-lives for targeted agents with half lives and pharmacodynamic effects lasting less than 5 days (that includes, but is not limited to, erlotinib, sorafenib, sunitinib, bortezomib, and other similar agents) d. failed to recover from toxic effects of any therapy prior to study entry
  9. Urine for proteinuria >/= 2+ (patients discovered to have >/= 2+ proteinuria on urinalysis at baseline should undergo a 24 hour urine collection and must demonstrate </= 1g of protein in 24 hours to be eligible).
  10. Patients with insulin dependent diabetes or poorly controlled type 2 diabetes.
  11. Inability to swallow oral medication.
  12. Pregnant or breastfeeding women.
  13. Concurrent enrollment on another research study.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01608139


Sponsors and Collaborators
M.D. Anderson Cancer Center
Sabinsa Corporation
Investigators
Layout table for investigator information
Principal Investigator: David S. Hong, MD UT MD Anderson Cancer Center

Additional Information:
Layout table for additonal information
Responsible Party: M.D. Anderson Cancer Center
ClinicalTrials.gov Identifier: NCT01608139     History of Changes
Other Study ID Numbers: 2009-0574
First Posted: May 30, 2012    Key Record Dates
Last Update Posted: October 19, 2012
Last Verified: October 2012
Keywords provided by M.D. Anderson Cancer Center:
Curcumin
Advanced Cancers
Advanced Solid Tumors
Sorafenib
Nexavar
Bay 43-9006
Vorinostat
SAHA
Suberoylanilide Hydroxamic Acid
MSK-390
Zolinza
Additional relevant MeSH terms:
Layout table for MeSH terms
Enzyme Inhibitors
Curcumin
Sorafenib
Vorinostat
Antineoplastic Agents
Protein Kinase Inhibitors
Molecular Mechanisms of Pharmacological Action
Histone Deacetylase Inhibitors
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents