Dietary Vitamin A Requirement in Chinese Children and the New Technology of Dietary Assessment
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ClinicalTrials.gov Identifier: NCT01559766
Recruitment Status :
First Posted : March 21, 2012
Last Update Posted : March 21, 2012
Huazhong University of Science and Technology
ShiYan Centre for Disease Control and Prevention
Tufts Medical Center
Information provided by (Responsible Party):
Xiufa Sun, Huazhong University of Science and Technology
Vitamin A deficiency remains a major public health problem in developing country worldwide. Young Children are considered to be at greatest risk of deficiency. However, there is little information on the vitamin A requirement of Chinese children. In the present study, about 400 children aged between 4 and 9 years old in a kindergarten and an elementary school of Shiyan City were screened before admission by questionnaire and anthropometric measurement. The vitamin A status of children was assessed by serum vitamin A level, relative dosage reaction and stable-isotope dilution technique. At the same time, their dietary vitamin A intakes were estimated by weighted-food dietary survey. The dietary vitamin A requirement in young children was determined on the basis of dietary vitamin A intakes in Children with adequate vitamin A level.
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Layout table for eligibility information
Ages Eligible for Study:
4 Years to 9 Years (Child)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
The study was carried out in a kindergarten and an elementary school in Shiyan city, Hubei province of China. Initially, 201 kindergarten children (4-6 years old) and 202 grade children (7-9 years old) were subjected to a questionnaire survey on personal information, medical history and dietary habits including dietary supplements.ongoing or previous illnesses, having taken nutritional supplements within 3 months, positive results in the fat absorption test or parasite test, increased level of CRP (> 8 mg/L), or lower serum level of retinol (<1.40 umol/L), and higher ratio in relative dosage reaction test(>20%) .After the screening, 123 children were selected and completed the study, but 60 subjects were randomly selected for the DRD test to evaluate liver vitamin A storage.
well-nourished children with normal serum retinol(>=1.40umol/L)
ongoing or previous illnesses,
having taken nutritional supplements within 3 months,
positive results in the fat absorption test or parasite test,