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Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery

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ClinicalTrials.gov Identifier: NCT01220583
Recruitment Status : Recruiting
First Posted : October 14, 2010
Last Update Posted : August 31, 2018
Sponsor:
Collaborators:
National Cancer Institute (NCI)
NRG Oncology
Information provided by (Responsible Party):
Radiation Therapy Oncology Group

Brief Summary:

RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. It is not yet known whether radiation therapy is more effective when given together with chemotherapy or alone after surgery in treating salivary gland tumors.

PURPOSE: This randomized phase II/III trial is studying radiation therapy with or without chemotherapy to see how well it works in treating patients with high-risk malignant salivary gland tumors that have been removed by surgery.


Condition or disease Intervention/treatment Phase
Head and Neck Cancer Drug: cisplatin Radiation: 3-dimensional conformal radiation therapy Radiation: intensity-modulated radiation therapy Phase 2

Detailed Description:

OBJECTIVES:

Primary

Phase II

  • Determine the feasibility of conducting a cooperative group prospective clinical trial in patients with resected malignant salivary gland tumors.
  • Acquire preliminary efficacy data comparing postoperative radiotherapy alone to concurrent chemotherapy and radiation using weekly cisplatin.

Phase III

* Compare overall survival rates among patients receiving cisplatin and radiation to those receiving radiation alone.

Secondary

Phase II/III

  • Compare the acute toxicities of these 2 adjuvant treatments.
  • Compare late treatment-related adverse events in patients receiving postoperative radiation to those receiving concurrent chemoradiation.
  • Compare progression-free survival rates among patients receiving cisplatin and radiation to those receiving radiation alone in both the cohort of patients with pathologically high-risk disease (high-grade adenocarcinoma, high-grade mucoepidermoid carcinoma, salivary duct carcinoma), and the patient cohort with pathologically intermediate-risk disease (all other eligible diagnoses).
  • Investigate quality of life and patient-reported outcomes in patients enrolled in the study.
  • Identify the histopathology and tumor marker expression from patients enrolled on this trial and assemble a tissue bank for future correlative studies.
  • Establish a NRG Oncology baseline database for salivary gland malignancies to serve as a resource for future exploration of innovative and/or targeted approaches for this disease.

OUTLINE: This is a multicenter study. Patients are stratified according to histology (high-grade mucoepidermoid carcinoma vs salivary duct carcinoma vs high-grade adenocarcinoma) and nodal status (N0 vs N1-3). Patients are randomized to 1 of 2 treatment arms.

  • Arm I: Patients undergo 3-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) 5 days a week for 6-6.5 weeks. Patients also receive cisplatin IV over 60 minutes on days 1, 8, 15, 22, 29, 36, and 43 during radiotherapy.
  • Arm II: Patients undergo 3D-CRT or IMRT as in Arm I. Tissue and blood samples may be collected for translational research studies. Patients may complete quality-of-life assessments periodically.

After completion of study treatment, patients are followed up at 3, 6, 9, 12, and 24 months, every 6 months for 2 years, and then annually thereafter.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Randomized Phase II/Phase III Study of Adjuvant Concurrent Radiation and Chemotherapy Versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors
Study Start Date : January 2011
Estimated Primary Completion Date : October 2023
Estimated Study Completion Date : October 2028

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Arm I
Patients undergo 3-dimensional conformal radiotherapy (3D-CRT) or intensity-modulated radiotherapy (IMRT) 5 days a week for 6-6.5 weeks. Patients also receive cisplatin IV over 60 minutes on days 1, 8, 15, 22, 29, 36, and 43 during radiotherapy.
Drug: cisplatin
Given IV

Radiation: 3-dimensional conformal radiation therapy
Undergo radiotherapy

Radiation: intensity-modulated radiation therapy
Undergo radiotherapy

Experimental: Arm II
Patients undergo 3D-CRT or IMRT as in arm I.
Radiation: 3-dimensional conformal radiation therapy
Undergo radiotherapy

Radiation: intensity-modulated radiation therapy
Undergo radiotherapy




Primary Outcome Measures :
  1. Progression-free survival (PFS), defined by the events of local-regional progression or recurrence, distant metastasis, or death from any cause, primarily at 2 years [ Time Frame: From randomization to 2 years. ]

Secondary Outcome Measures :
  1. Overall survival (OS) rate at 2 years [ Time Frame: From randomization to 2 years. ]
  2. PFS rate at 5 years [ Time Frame: From randomization to 5 years. ]
  3. OS rate at 5 years [ Time Frame: From randomization to 5 years. ]
  4. Treatment-related toxicity, defined as any grade 3-4 adverse events (CTCAE v. 4) deemed to be definitely, probably, or possibly related to protocol treatment [ Time Frame: From start of treatment to last follow-up. ]
  5. Treatment-related mortality, defined as any death during or within 30 days of discontinuation of protocol treatment [ Time Frame: From start of treatment to 30 days after the end of treatment. ]
  6. Chemotherapy delivery as measured by percentage of protocol prescription given [ Time Frame: From start of treatment to end of treatment. ]
  7. Radiation delivery as measured by elapsed treatment days [ Time Frame: From start of treatment to end of treatment. ]
  8. Determine whether quality of life, fatigue and xerostomia differ as a function of treatment assignment at 3, 12, and 24 months after completing radiotherapy. [ Time Frame: From randomization to 2 years. ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Pathologically proven diagnosis of a malignant major salivary gland tumor or malignant minor salivary gland tumor of the head and neck of the following histologic subtypes:

    • Intermediate-grade adenocarcinoma or intermediate-grade mucoepidermoid carcinoma
    • High-grade acinic cell carcinoma or high-grade (>30% solid component) adenoid cystic carcinoma
  • Surgical resection with curative intent within 8 weeks prior to registration
  • All patients must have a Medical Oncology evaluation within 4 weeks prior to registration
  • Pathologic stage T3-4 or N1-3 or T1-2, N0 with a close (≤ 1mm) or microscopically positive surgical margin; patients must be free of distant metastases based upon the following minimum diagnostic workup:

    • History/physical examination within 8 weeks prior to registration
    • Radiologic confirmation of the absence of hematogenous metastasis within 12 weeks prior to registration; at a minimum, contrast CT imaging of the chest is required (PET/CT is acceptable)
  • No patients with residual macroscopic disease after surgery
  • No prior systemic chemotherapy or radiation therapy for salivary gland malignancy

PATIENT CHARACTERISTICS:

  • Zubrod performance status 0-1
  • Absolute neutrophil count (ANC) ≥ 1,800 cells/mm^3
  • Platelets ≥ 100,000 cells/mm^3
  • Hemoglobin ≥ 8.0 g/dL (the use of transfusion or other intervention to achieve hemoglobin ≥ 8.0 g/dL is acceptable)
  • Serum creatinine < 2.0 mg/dL
  • Total bilirubin < 2 x the institutional upper limit of normal (ULN)
  • Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the institutional ULN
  • Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential
  • Women of childbearing potential and male participants who are sexually active must practice adequate contraception during treatment and for 6 weeks following treatment
  • Not pregnant or nursing
  • Patients must be deemed able to comply with the treatment plan and follow-up schedule
  • Patients must provide study specific informed consent prior to study entry, including consent for mandatory tissue submission for central review
  • No prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years (for example, carcinoma in situ of the breast, oral cavity, or cervix are all permissible)
  • No severe, active co-morbidity, defined as follows:

    • Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months
    • Transmural myocardial infarction within the last 6 months
    • Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
    • Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
    • Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects (coagulation parameters are not required for entry into this protocol)
    • Acquired immune deficiency syndrome (AIDS) based upon current Centers for Disease Control (CDC) definition (HIV testing is not required for entry into this protocol)

      • Protocol-specific requirements may also exclude immunocompromised patients
    • Pre-existing ≥ grade 2 neuropathy
  • No significant pre-existing hearing loss, as defined by the patient or treating physician

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • No prior systemic chemotherapy or radiation therapy for salivary gland malignancy (prior chemotherapy for a different cancer is allowable)
  • No prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields
  • No prior organ transplant
  • No concurrent hematopoietic growth factors (e.g., G-CSF or pegfilgrastim) during radiotherapy
  • No concurrent erythropoiesis-stimulating agents

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01220583


  Hide Study Locations
Locations
United States, Alabama
University of Alabama at Birmingham Cancer Center Recruiting
Birmingham, Alabama, United States, 35233
Contact: Site Public Contact    205-934-0220    tmyrick@uab.edu   
Principal Investigator: Sharon A. Spencer         
The Kirklin Clinic at Acton Road Suspended
Birmingham, Alabama, United States, 35243
United States, Arizona
Arizona Breast Cancer Specialists-Gilbert Recruiting
Gilbert, Arizona, United States, 85297
Contact: Site Public Contact    480-922-4600      
Principal Investigator: Christopher A. Biggs         
Arizona Center for Cancer Care-Peoria Recruiting
Peoria, Arizona, United States, 85381
Contact: Site Public Contact    623-773-2873      
Principal Investigator: Christopher A. Biggs         
University of Arizona Cancer Center at Saint Joseph's Active, not recruiting
Phoenix, Arizona, United States, 85004
Arizona Breast Cancer Specialists-Phoenix Recruiting
Phoenix, Arizona, United States, 85027
Contact: Site Public Contact    480-922-4600    renee.schein@arizonaccc.com   
Principal Investigator: Christopher A. Biggs         
Arizona Oncology-Deer Valley Center Suspended
Phoenix, Arizona, United States, 85027
Arizona Breast Cancer Specialists Recruiting
Scottsdale, Arizona, United States, 85251
Contact: Site Public Contact    480-922-4600      
Principal Investigator: Christopher A. Biggs         
Arizona Breast Cancer Specialists-Scottsdale Recruiting
Scottsdale, Arizona, United States, 85258
Contact: Site Public Contact    480-922-4600      
Principal Investigator: Christopher A. Biggs         
Arizona Oncology Services Foundation Active, not recruiting
Scottsdale, Arizona, United States, 85260
Arizona Center for Cancer Care-Surprise Recruiting
Surprise, Arizona, United States, 85374
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Christopher A. Biggs         
University of Arizona Cancer Center-Orange Grove Campus Suspended
Tucson, Arizona, United States, 85704
University of Arizona Cancer Center-North Campus Recruiting
Tucson, Arizona, United States, 85719
Contact: Site Public Contact    800-327-2873      
Principal Investigator: Simran K. Sindhu         
The University of Arizona Medical Center-University Campus Recruiting
Tucson, Arizona, United States, 85724
Contact: Site Public Contact    520-626-9008      
Principal Investigator: Simran K. Sindhu         
United States, California
Sutter Cancer Centers Radiation Oncology Services-Auburn Active, not recruiting
Auburn, California, United States, 95603
AIS Cancer Center at San Joaquin Community Hospital Recruiting
Bakersfield, California, United States, 93301
Contact: Site Public Contact    661-323-4673      
Principal Investigator: Shyam S. Rao         
Mills-Peninsula Medical Center Active, not recruiting
Burlingame, California, United States, 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park Active, not recruiting
Cameron Park, California, United States, 95682
Mercy San Juan Medical Center Suspended
Carmichael, California, United States, 95608
City of Hope Comprehensive Cancer Center Active, not recruiting
Duarte, California, United States, 91010
UC San Diego Moores Cancer Center Recruiting
La Jolla, California, United States, 92093
Contact: Site Public Contact    858-822-5354    cancercto@ucsd.edu   
Principal Investigator: Loren K. Mell         
Los Angeles County-USC Medical Center Recruiting
Los Angeles, California, United States, 90033
Contact: Site Public Contact    323-865-0451      
Principal Investigator: Richard L. Jennelle         
USC / Norris Comprehensive Cancer Center Recruiting
Los Angeles, California, United States, 90033
Contact: Site Public Contact    323-865-0451      
Principal Investigator: Richard L. Jennelle         
Fremont - Rideout Cancer Center Recruiting
Marysville, California, United States, 95901
Contact: Site Public Contact    530-749-4400      
Principal Investigator: Shyam S. Rao         
Memorial Medical Center Active, not recruiting
Modesto, California, United States, 95355
Hoag Memorial Hospital Recruiting
Newport Beach, California, United States, 92663
Contact: Site Public Contact    949-722-6237    HoagCancerCenter@hoag.org   
Principal Investigator: Richard L. Jennelle         
Stanford Cancer Institute Palo Alto Recruiting
Palo Alto, California, United States, 94304
Contact: Site Public Contact    650-498-7061    ccto-office@stanford.edu   
Principal Investigator: Quynh-Thu X. Le         
Sutter Cancer Centers Radiation Oncology Services-Roseville Active, not recruiting
Roseville, California, United States, 95661
Sutter Medical Center Sacramento Active, not recruiting
Sacramento, California, United States, 95816
University of California Davis Comprehensive Cancer Center Recruiting
Sacramento, California, United States, 95817
Contact: Site Public Contact    916-734-3089      
Principal Investigator: Shyam S. Rao         
UCSF Medical Center-Mount Zion Suspended
San Francisco, California, United States, 94115
Sutter Cancer Centers Radiation Oncology Services-Vacaville Active, not recruiting
Vacaville, California, United States, 95687
United States, Colorado
Rocky Mountain Cancer Centers-Aurora Suspended
Aurora, Colorado, United States, 80012
University of Colorado Hospital Recruiting
Aurora, Colorado, United States, 80045
Contact: Site Public Contact    720-848-0650      
Principal Investigator: Sana D. Karam         
Boulder Community Hospital Suspended
Boulder, Colorado, United States, 80301
Penrose-Saint Francis Healthcare Suspended
Colorado Springs, Colorado, United States, 80907
Porter Adventist Hospital Suspended
Denver, Colorado, United States, 80210
Swedish Medical Center Suspended
Englewood, Colorado, United States, 80113
Rocky Mountain Cancer Centers-Littleton Suspended
Littleton, Colorado, United States, 80120
Longmont United Hospital Suspended
Longmont, Colorado, United States, 80501
McKee Medical Center Suspended
Loveland, Colorado, United States, 80539
North Suburban Medical Center Suspended
Thornton, Colorado, United States, 80229
Rocky Mountain Cancer Centers-Thornton Suspended
Thornton, Colorado, United States, 80260
United States, Connecticut
William Backus Hospital Active, not recruiting
Norwich, Connecticut, United States, 06360
United States, Delaware
Helen F Graham Cancer Center Recruiting
Newark, Delaware, United States, 19713
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Adam Raben         
Christiana Care Health System-Christiana Hospital Recruiting
Newark, Delaware, United States, 19718
Contact: Site Public Contact    302-623-4450    KDempsey@christianacare.org   
Principal Investigator: Adam Raben         
Beebe Health Campus Recruiting
Rehoboth Beach, Delaware, United States, 19971
Contact: Site Public Contact    302-645-3100    Dmiskin@Beebehealthcare.org   
Principal Investigator: Adam Raben         
United States, Florida
UM Sylvester Comprehensive Cancer Center at Coral Gables Recruiting
Coral Gables, Florida, United States, 33146
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Michael A. Samuels         
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Recruiting
Deerfield Beach, Florida, United States, 33442
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Michael A. Samuels         
University of Florida Health Science Center - Gainesville Active, not recruiting
Gainesville, Florida, United States, 32610
University of Florida Health Science Center - Jacksonville Suspended
Jacksonville, Florida, United States, 32209
University of Miami Miller School of Medicine-Sylvester Cancer Center Recruiting
Miami, Florida, United States, 33136
Contact: Site Public Contact    305-243-2647      
Principal Investigator: Michael A. Samuels         
UF Cancer Center at Orlando Health Recruiting
Orlando, Florida, United States, 32806
Contact: Site Public Contact    321-841-7246    CancerClinicalTrials@orlandohealth.com   
Principal Investigator: Rafael R. Manon         
Moffitt Cancer Center Recruiting
Tampa, Florida, United States, 33612
Contact: Site Public Contact    800-456-7121    canceranswers@moffitt.org   
Principal Investigator: Jimmy J. Caudell         
United States, Georgia
Emory University Hospital Midtown Recruiting
Atlanta, Georgia, United States, 30308
Contact: Site Public Contact    888-946-7447      
Principal Investigator: Jonathan J. Beitler         
Emory University Hospital/Winship Cancer Institute Recruiting
Atlanta, Georgia, United States, 30322
Contact: Site Public Contact    404-778-1868      
Principal Investigator: Jonathan J. Beitler         
United States, Idaho
Saint Alphonsus Cancer Care Center-Boise Recruiting
Boise, Idaho, United States, 83706
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Kootenai Cancer Center Recruiting
Post Falls, Idaho, United States, 83854
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
United States, Illinois
Northwestern University Active, not recruiting
Chicago, Illinois, United States, 60611
John H Stroger Jr Hospital of Cook County Suspended
Chicago, Illinois, United States, 60612
Loyola University Medical Center Recruiting
Maywood, Illinois, United States, 60153
Contact: Site Public Contact    708-226-4357      
Principal Investigator: Alec M. Block         
Saint John's Hospital Active, not recruiting
Springfield, Illinois, United States, 62702
United States, Indiana
Goshen Center for Cancer Care Active, not recruiting
Goshen, Indiana, United States, 46526
Memorial Hospital of South Bend Suspended
South Bend, Indiana, United States, 46601
United States, Iowa
McFarland Clinic PC - Ames Active, not recruiting
Ames, Iowa, United States, 50010
Iowa Methodist Medical Center Recruiting
Des Moines, Iowa, United States, 50309
Contact: Site Public Contact    515-241-6727      
Principal Investigator: Robert J. Behrens         
Mercy Medical Center - Des Moines Suspended
Des Moines, Iowa, United States, 50314
University of Iowa/Holden Comprehensive Cancer Center Recruiting
Iowa City, Iowa, United States, 52242
Contact: Site Public Contact    800-237-1225      
Principal Investigator: Mark C. Smith         
Siouxland Regional Cancer Center Recruiting
Sioux City, Iowa, United States, 51101
Contact: Site Public Contact    712-252-0088      
Principal Investigator: Donald B. Wender         
United States, Kansas
University of Kansas Cancer Center Suspended
Kansas City, Kansas, United States, 66160
United States, Kentucky
University of Kentucky/Markey Cancer Center Active, not recruiting
Lexington, Kentucky, United States, 40536
The James Graham Brown Cancer Center at University of Louisville Suspended
Louisville, Kentucky, United States, 40202
United States, Louisiana
Mary Bird Perkins Cancer Center Suspended
Baton Rouge, Louisiana, United States, 70809
University Medical Center New Orleans Active, not recruiting
New Orleans, Louisiana, United States, 70112
Touro Infirmary Active, not recruiting
New Orleans, Louisiana, United States, 70115
Ochsner Medical Center Jefferson Recruiting
New Orleans, Louisiana, United States, 70121
Contact: Site Public Contact    504-703-8712    Gregory.Johnstone@ochsner.org   
Principal Investigator: Brian A. Moore         
United States, Maryland
Greater Baltimore Medical Center Suspended
Baltimore, Maryland, United States, 21204
Johns Hopkins University/Sidney Kimmel Cancer Center Suspended
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Boston Medical Center Recruiting
Boston, Massachusetts, United States, 02118
Contact: Site Public Contact    617-638-8265      
Principal Investigator: Minh T. Truong         
United States, Michigan
Bixby Medical Center Suspended
Adrian, Michigan, United States, 49221
Saint Joseph Mercy Hospital Recruiting
Ann Arbor, Michigan, United States, 48106
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
University of Michigan Comprehensive Cancer Center Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Site Public Contact    800-865-1125      
Principal Investigator: Michelle L. Mierzwa         
Henry Ford Cancer Institute?Downriver Recruiting
Brownstown, Michigan, United States, 48183
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Eleanor M. Walker         
Henry Ford Macomb Hospital-Clinton Township Recruiting
Clinton Township, Michigan, United States, 48038
Contact: Site Public Contact    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Henry Ford Hospital Recruiting
Detroit, Michigan, United States, 48202
Contact: Site Public Contact    313-916-1784      
Principal Investigator: Eleanor M. Walker         
Saint John Hospital and Medical Center Recruiting
Detroit, Michigan, United States, 48236
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
West Michigan Cancer Center Recruiting
Kalamazoo, Michigan, United States, 49007
Contact: Site Public Contact    616-391-1230    crcwm-regulatory@crcwm.org   
Principal Investigator: Sunil Nagpal         
Saint Mary Mercy Hospital Recruiting
Livonia, Michigan, United States, 48154
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Saint Joseph Mercy Oakland Recruiting
Pontiac, Michigan, United States, 48341
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Lake Huron Medical Center Suspended
Port Huron, Michigan, United States, 48060
Saint Mary's of Michigan Recruiting
Saginaw, Michigan, United States, 48601
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Samir Narayan         
Saint John Macomb-Oakland Hospital Recruiting
Warren, Michigan, United States, 48093
Contact: Site Public Contact    734-712-3671    stephanie.couch@stjoeshealth.org   
Principal Investigator: Samir Narayan         
Henry Ford West Bloomfield Hospital Recruiting
West Bloomfield, Michigan, United States, 48322
Contact: Site Public Contact    888-734-5322      
Principal Investigator: Eleanor M. Walker         
United States, Minnesota
Mayo Clinic Recruiting
Rochester, Minnesota, United States, 55905
Contact: Site Public Contact    855-776-0015      
Principal Investigator: Robert L. Foote         
United States, Mississippi
University of Mississippi Medical Center Active, not recruiting
Jackson, Mississippi, United States, 39216
United States, Missouri
Siteman Cancer Center at West County Hospital Recruiting
Creve Coeur, Missouri, United States, 63141
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Douglas R. Adkins         
Saint Louis University Hospital Suspended
Saint Louis, Missouri, United States, 63110
Washington University School of Medicine Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Douglas R. Adkins         
Siteman Cancer Center-South County Recruiting
Saint Louis, Missouri, United States, 63129
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Douglas R. Adkins         
Siteman Cancer Center at Saint Peters Hospital Recruiting
Saint Peters, Missouri, United States, 63376
Contact: Site Public Contact    800-600-3606    info@siteman.wustl.edu   
Principal Investigator: Douglas R. Adkins         
United States, Montana
Billings Clinic Cancer Center Recruiting
Billings, Montana, United States, 59101
Contact: Site Public Contact    800-996-2663    research@billingsclinic.org   
Principal Investigator: Benjamin T. Marchello         
Bozeman Deaconess Hospital Recruiting
Bozeman, Montana, United States, 59715
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
Kalispell Regional Medical Center Recruiting
Kalispell, Montana, United States, 59901
Contact: Site Public Contact    406-969-6060    mccinfo@mtcancer.org   
Principal Investigator: Benjamin T. Marchello         
United States, Nebraska
Nebraska Methodist Hospital Recruiting
Omaha, Nebraska, United States, 68114
Contact: Site Public Contact    402-354-5144      
Principal Investigator: Tien-Shew W. Huang         
Alegent Health Bergan Mercy Medical Center Suspended
Omaha, Nebraska, United States, 68124
United States, Nevada
Comprehensive Cancer Centers of Nevada - Henderson Suspended
Henderson, Nevada, United States, 89052
Radiation Oncology Centers of Nevada Central Active, not recruiting
Las Vegas, Nevada, United States, 89106
Comprehensive Cancer Centers of Nevada - Northwest Suspended
Las Vegas, Nevada, United States, 89128
Comprehensive Cancer Centers of Nevada-Summerlin Suspended
Las Vegas, Nevada, United States, 89144
Comprehensive Cancer Centers of Nevada Suspended
Las Vegas, Nevada, United States, 89148
Comprehensive Cancer Centers of Nevada - Central Valley Suspended
Las Vegas, Nevada, United States, 89169
United States, New Hampshire
Dartmouth Hitchcock Medical Center Recruiting
Lebanon, New Hampshire, United States, 03756
Contact: Site Public Contact    800-639-6918    cancer.research.nurse@dartmouth.edu   
Principal Investigator: Thomas H. Davis         
United States, New Jersey
Memorial Sloan Kettering Basking Ridge Recruiting
Basking Ridge, New Jersey, United States, 07920
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Memorial Sloan Kettering Monmouth Recruiting
Middletown, New Jersey, United States, 07748
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Virtua Memorial Active, not recruiting
Mount Holly, New Jersey, United States, 08060
Rutgers New Jersey Medical School Suspended
Newark, New Jersey, United States, 07101
Sparta Cancer Treatment Center Recruiting
Sparta, New Jersey, United States, 07871
Contact: Site Public Contact    973-729-7001      
Principal Investigator: Voichita Bar Ad         
Virtua Voorhees Active, not recruiting
Voorhees, New Jersey, United States, 08043
United States, New Mexico
University of New Mexico Cancer Center Suspended
Albuquerque, New Mexico, United States, 87102
United States, New York
Northwell Health Imbert Cancer Center Recruiting
Bay Shore, New York, United States, 11706
Contact: Site Public Contact    516-734-8896      
Principal Investigator: Maged Ghaly         
Maimonides Medical Center Suspended
Brooklyn, New York, United States, 11219
Memorial Sloan Kettering Commack Recruiting
Commack, New York, United States, 11725
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Memorial Sloan Kettering Westchester Recruiting
Harrison, New York, United States, 10604
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Northwell Health/Center for Advanced Medicine Recruiting
Lake Success, New York, United States, 11042
Contact: Site Public Contact    516-734-8896      
Principal Investigator: Maged Ghaly         
Long Island Jewish Medical Center Recruiting
New Hyde Park, New York, United States, 11040
Contact: Site Public Contact    516-734-8896      
Principal Investigator: Maged Ghaly         
Mount Sinai Union Square Suspended
New York, New York, United States, 10003
Mount Sinai Chelsea Recruiting
New York, New York, United States, 10011
Contact: Site Public Contact    212-824-7309    CCTO@mssm.edu   
Principal Investigator: Richard L. Bakst         
Lenox Hill Hospital Recruiting
New York, New York, United States, 10021
Contact: Site Public Contact    516-734-8896      
Principal Investigator: Maged Ghaly         
Mount Sinai Hospital Recruiting
New York, New York, United States, 10029
Contact: Site Public Contact    212-824-7309    CCTO@mssm.edu   
Principal Investigator: Richard L. Bakst         
Memorial Sloan Kettering Cancer Center Recruiting
New York, New York, United States, 10065
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Highland Hospital Suspended
Rochester, New York, United States, 14620
University of Rochester Recruiting
Rochester, New York, United States, 14642
Contact: Site Public Contact    585-275-5830      
Principal Investigator: Yuhchyau Chen         
Memorial Sloan Kettering Rockville Centre Recruiting
Rockville Centre, New York, United States, 11570
Contact: Site Public Contact    212-639-7592      
Principal Investigator: Nancy Y. Lee         
Memorial Sloan Kettering Sleepy Hollow Suspended
Sleepy Hollow, New York, United States, 10591
State University of New York Upstate Medical University Recruiting
Syracuse, New York, United States, 13210
Contact: Site Public Contact    315-464-5476      
Principal Investigator: Seung S. Hahn         
United States, North Carolina
UNC Lineberger Comprehensive Cancer Center Recruiting
Chapel Hill, North Carolina, United States, 27599
Contact: Site Public Contact    877-668-0683    cancerclinicaltrials@med.unc.edu   
Principal Investigator: Bhishamjit S. Chera         
Duke University Medical Center Active, not recruiting
Durham, North Carolina, United States, 27710
United States, Ohio
Summa Akron City Hospital/Cooper Cancer Center Active, not recruiting
Akron, Ohio, United States, 44304
Summa Barberton Hospital Active, not recruiting
Barberton, Ohio, United States, 44203
University of Cincinnati/Barrett Cancer Center Recruiting
Cincinnati, Ohio, United States, 45219
Contact: Site Public Contact    513-558-4553    uchealthnews@uc.edu   
Principal Investigator: Kevin P. Redmond         
Case Western Reserve University Recruiting
Cleveland, Ohio, United States, 44106
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
Cleveland Clinic Foundation Recruiting
Cleveland, Ohio, United States, 44195
Contact: Site Public Contact    866-223-8100    CancerAnswer@ccf.org   
Principal Investigator: David J. Adelstein         
Ohio State University Comprehensive Cancer Center Suspended
Columbus, Ohio, United States, 43210
Mercy Cancer Center-Elyria Recruiting
Elyria, Ohio, United States, 44035
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
Summa Health Center at Lake Medina Active, not recruiting
Medina, Ohio, United States, 44256
Lake University Ireland Cancer Center Recruiting
Mentor, Ohio, United States, 44060
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
Southwest General Health Center Ireland Cancer Center Recruiting
Middleburg Heights, Ohio, United States, 44130
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
University Hospitals Parma Medical Center Recruiting
Parma, Ohio, United States, 44129
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
UH Seidman Cancer Center at Salem Regional Medical Center Suspended
Salem, Ohio, United States, 44460
Ireland Cancer Center at Firelands Regional Medical Center Recruiting
Sandusky, Ohio, United States, 44870
Contact: Site Public Contact    800-641-2422    CTUReferral@UHhospitals.org   
Principal Investigator: David J. Adelstein         
Flower Hospital Recruiting
Sylvania, Ohio, United States, 43560
Contact: Site Public Contact    419-824-1842      
Principal Investigator: Abhijit B. Saste         
University of Toledo Suspended
Toledo, Ohio, United States, 43614
Mercy Saint Anne Hospital Suspended
Toledo, Ohio, United States, 43623
University Pointe Recruiting
West Chester, Ohio, United States, 45069
Contact: Site Public Contact       clinicaltrials@ucphysicians.com   
Principal Investigator: Kevin P. Redmond         
Cancer Treatment Center Suspended
Wooster, Ohio, United States, 44691
United States, Oklahoma
University of Oklahoma Health Sciences Center Suspended
Oklahoma City, Oklahoma, United States, 73104
United States, Oregon
Clackamas Radiation Oncology Center Recruiting
Clackamas, Oregon, United States, 97015
Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Benjamin B. Bridges         
Providence Portland Medical Center Recruiting
Portland, Oregon, United States, 97213
Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Benjamin B. Bridges         
Providence Saint Vincent Medical Center Recruiting
Portland, Oregon, United States, 97225
Contact: Site Public Contact    503-215-2614    CanRsrchStudies@providence.org   
Principal Investigator: Benjamin B. Bridges         
Oregon Health and Science University Recruiting
Portland, Oregon, United States, 97239
Contact: Site Public Contact    503-494-1080    trials@ohsu.edu   
Principal Investigator: John M. Holland         
United States, Pennsylvania
Bryn Mawr Hospital Recruiting
Bryn Mawr, Pennsylvania, United States, 19010
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
Geisinger Medical Center Recruiting
Danville, Pennsylvania, United States, 17822
Contact: Site Public Contact    570-271-5251    HemonCCTrials@geisinger.edu   
Principal Investigator: Michael J. Greenberg         
UPMC Cancer Centers - Arnold Palmer Pavilion Recruiting
Greensburg, Pennsylvania, United States, 15601
Contact: Site Public Contact    724-838-1900      
Principal Investigator: James P. Ohr         
Penn State Milton S Hershey Medical Center Active, not recruiting
Hershey, Pennsylvania, United States, 17033-0850
Lewistown Hospital Recruiting
Lewistown, Pennsylvania, United States, 17044
Contact: Site Public Contact    717-242-7703    HemonCCTrials@geisinger.edu   
Principal Investigator: Michael J. Greenberg         
UPMC-Coraopolis/Heritage Valley Radiation Oncology Recruiting
Moon, Pennsylvania, United States, 15108
Contact: Site Public Contact    412-604-2020      
Principal Investigator: James P. Ohr         
UPMC Jameson Suspended
New Castle, Pennsylvania, United States, 16105
Paoli Memorial Hospital Recruiting
Paoli, Pennsylvania, United States, 19301
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
Thomas Jefferson University Hospital Recruiting
Philadelphia, Pennsylvania, United States, 19107
Contact: Site Public Contact    215-955-6084      
Principal Investigator: Voichita Bar Ad         
Fox Chase Cancer Center Suspended
Philadelphia, Pennsylvania, United States, 19111
Temple University Hospital Suspended
Philadelphia, Pennsylvania, United States, 19140
UPMC-Saint Margaret Recruiting
Pittsburgh, Pennsylvania, United States, 15215
Contact: Site Public Contact    412-784-4900      
Principal Investigator: James P. Ohr         
UPMC-Shadyside Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15232
Contact: Site Public Contact    412-621-2334      
Principal Investigator: James P. Ohr         
UPMC Jefferson Regional Radiation Oncology Suspended
Pittsburgh, Pennsylvania, United States, 15236
UPMC-Passavant Hospital Recruiting
Pittsburgh, Pennsylvania, United States, 15237
Contact: Site Public Contact    412-367-6454      
Principal Investigator: James P. Ohr         
UPMC-Saint Clair Hospital Cancer Center Recruiting
Pittsburgh, Pennsylvania, United States, 15243
Contact: Site Public Contact    412-502-3920      
Principal Investigator: James P. Ohr         
Geisinger Wyoming Valley/Henry Cancer Center Recruiting
Wilkes-Barre, Pennsylvania, United States, 18711
Contact: Site Public Contact    570-271-5251    HemonCCTrials@geisinger.edu   
Principal Investigator: Michael J. Greenberg         
Lankenau Medical Center Recruiting
Wynnewood, Pennsylvania, United States, 19096
Contact: Site Public Contact    484-476-2649    turzoe@mlhs.org   
Principal Investigator: Albert S. DeNittis         
United States, South Carolina
Medical University of South Carolina Recruiting
Charleston, South Carolina, United States, 29425
Contact: Site Public Contact    843-792-9321    hcc-clinical-trials@musc.edu   
Principal Investigator: Joshua D. Hornig         
Greenville Health System Cancer Institute-Faris Suspended
Greenville, South Carolina, United States, 29605
Greenville Health System Cancer Institute-Eastside Suspended
Greenville, South Carolina, United States, 29615
Greenville Health System Cancer Institute-Greer Suspended
Greer, South Carolina, United States, 29650
Greenville Health System Cancer Institute-Seneca Suspended
Seneca, South Carolina, United States, 29672
Greenville Health System Cancer Institute-Spartanburg Suspended
Spartanburg, South Carolina, United States, 29307
United States, South Dakota
Rapid City Regional Hospital Active, not recruiting
Rapid City, South Dakota, United States, 57701
United States, Tennessee
University of Tennessee - Knoxville Recruiting
Knoxville, Tennessee, United States, 37920
Contact: Site Public Contact    865-544-9773      
Principal Investigator: Joseph R. Kelley         
Vanderbilt University/Ingram Cancer Center Suspended
Nashville, Tennessee, United States, 37232
United States, Texas
UT Southwestern/Simmons Cancer Center-Dallas Recruiting
Dallas, Texas, United States, 75390
Contact: Site Public Contact    214-648-7097    canceranswerline@UTSouthwestern.edu   
Principal Investigator: David J. Sher         
M D Anderson Cancer Center Suspended
Houston, Texas, United States, 77030
MD Anderson Regional Care Center-Katy Suspended
Houston, Texas, United States, 77094
MD Anderson Regional Care Center-Bay Area Suspended
Nassau Bay, Texas, United States, 77058
MD Anderson Regional Care Center-Sugar Land Suspended
Sugar Land, Texas, United States, 77478
MD Anderson Regional Care Center-The Woodlands Suspended
The Woodlands, Texas, United States, 77384
United States, Utah
American Fork Hospital / Huntsman Intermountain Cancer Center Recruiting
American Fork, Utah, United States, 84003
Contact: Site Public Contact    801-855-4100    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
Logan Regional Hospital Recruiting
Logan, Utah, United States, 84321
Contact: Site Public Contact    435-716-6400    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
Intermountain Medical Center Recruiting
Murray, Utah, United States, 84107
Contact: Site Public Contact    801-507-3950    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
Utah Valley Regional Medical Center Recruiting
Provo, Utah, United States, 84604
Contact: Site Public Contact    801-357-7965    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
Dixie Medical Center Regional Cancer Center Recruiting
Saint George, Utah, United States, 84770
Contact: Site Public Contact    435-688-4167    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
Utah Cancer Specialists-Salt Lake City Recruiting
Salt Lake City, Utah, United States, 84106
Contact: Site Public Contact    801-933-6070    officeofresearch@imail.org   
Principal Investigator: Vilija N. Avizonis         
United States, Vermont
Norris Cotton Cancer Center-North Recruiting
Saint Johnsbury, Vermont, United States, 05819
Contact: Site Public Contact    802-473-4100      
Principal Investigator: Thomas H. Davis         
United States, Virginia
Inova Fairfax Hospital Suspended
Falls Church, Virginia, United States, 22042
Sentara Cancer Institute at Sentara CarePlex Hospital Active, not recruiting
Hampton, Virginia, United States, 23666
Sentara Norfolk General Hospital Active, not recruiting
Norfolk, Virginia, United States, 23507
Sentara Virginia Beach General Hospital Active, not recruiting
Virginia Beach, Virginia, United States, 23454
United States, Washington
Saint Francis Hospital Suspended
Federal Way, Washington, United States, 98003
Virginia Mason Medical Center Active, not recruiting
Seattle, Washington, United States, 98101
Seattle Cancer Care Alliance at Northwest Hospital Recruiting
Seattle, Washington, United States, 98133
Contact: Site Public Contact    206-606-5800      
Principal Investigator: Cristina P. Rodriguez         
University of Washington Medical Center Recruiting
Seattle, Washington, United States, 98195
Contact: Site Public Contact    800-804-8824      
Principal Investigator: Cristina P. Rodriguez         
PeaceHealth Southwest Medical Center Recruiting
Vancouver, Washington, United States, 98664
Contact: Site Public Contact    360-514-3940    kmakin-bond@peacehealth.org   
Principal Investigator: Benjamin B. Bridges         
Compass Oncology Vancouver Suspended
Vancouver, Washington, United States, 98684
United States, West Virginia
West Virginia University Healthcare Recruiting
Morgantown, West Virginia, United States, 26506
Contact: Site Public Contact    304-293-7374    cancertrialsinfo@hsc.wvu.edu   
Principal Investigator: Todd C. Tenenholz         
Wheeling Hospital/Schiffler Cancer Center Suspended
Wheeling, West Virginia, United States, 26003
United States, Wisconsin
Aurora Cancer Care-Grafton Recruiting
Grafton, Wisconsin, United States, 53024
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Green Bay Oncology at Saint Vincent Hospital Recruiting
Green Bay, Wisconsin, United States, 54301-3526
Contact: Eva N. Christensen    920-433-8889      
Principal Investigator: Eva N. Christensen         
Saint Vincent Hospital Cancer Center Green Bay Recruiting
Green Bay, Wisconsin, United States, 54301
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
Saint Vincent Hospital Cancer Center at Saint Mary's Recruiting
Green Bay, Wisconsin, United States, 54303
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Eva N. Christensen         
Aurora BayCare Medical Center Recruiting
Green Bay, Wisconsin, United States, 54311
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Aurora Cancer Care-Kenosha South Recruiting
Kenosha, Wisconsin, United States, 53142
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
University of Wisconsin Hospital and Clinics Recruiting
Madison, Wisconsin, United States, 53792
Contact: Site Public Contact    800-622-8922      
Principal Investigator: Paul M. Harari         
Bay Area Medical Center Active, not recruiting
Marinette, Wisconsin, United States, 54143
Aurora Saint Luke's Medical Center Recruiting
Milwaukee, Wisconsin, United States, 53215
Contact: Site Public Contact    412-339-5294    Roster@nrgoncology.org   
Principal Investigator: Ellen L. Ziaja         
Froedtert and the Medical College of Wisconsin Recruiting
Milwaukee, Wisconsin, United States, 53226
Contact: Site Public Contact    414-805-4380      
Principal Investigator: Christopher J. Schultz         
Saint Vincent Hospital Cancer Center at Sturgeon Bay Recruiting
Sturgeon Bay, Wisconsin, United States, 54235-1495
Contact: Site Public Contact    920-433-8889    Christy.Gilchrist@hshs.org   
Principal Investigator: Eva N. Christensen         
Aurora Medical Center in Summit Recruiting
Summit, Wisconsin, United States, 53066
Contact: Site Public Contact    414-302-2304    ncorp@aurora.org   
Principal Investigator: Ellen L. Ziaja         
Canada, Alberta
Cross Cancer Institute Recruiting
Edmonton, Alberta, Canada, T6G 1Z2
Contact: Site Public Contact    780-432-8500      
Principal Investigator: Rufus A. Scrimger         
Canada, Ontario
London Regional Cancer Program Suspended
London, Ontario, Canada, N6A 4L6
Health Sciences North Active, not recruiting
Sudbury, Ontario, Canada, P3E 5J1
University Health Network-Princess Margaret Hospital Recruiting
Toronto, Ontario, Canada, M5G 2M9
Contact: Site Public Contact    416-946-4501    clinical.trials@uhn.on.ca   
Principal Investigator: John (Joon-Hyung) Kim         
Canada, Quebec
CHUM - Hopital Notre-Dame Active, not recruiting
Montreal, Quebec, Canada, H2L 4M1
McGill University Department of Oncology Suspended
Montreal, Quebec, Canada, H2W 1S6
CHUM - Centre Hospitalier de l'Universite de Montreal Suspended
Montreal, Quebec, Canada, H2X 3E4
The Research Institute of the McGill University Health Centre (MUHC) Recruiting
Montreal, Quebec, Canada, H3H 2R9
Contact: Site Public Contact    514-934-1934 ext 48354    evelyn.ortega@muhc.mcgill.ca   
Principal Investigator: George Shenouda         
Saudi Arabia
King Faisal Specialist Hospital and Research Centre Recruiting
Riyadh, Saudi Arabia, 11211
Contact: Site Public Contact    011-966-1-464-7272 ext 38005      
Principal Investigator: Nasser Al-Rajhi         
Sponsors and Collaborators
Radiation Therapy Oncology Group
National Cancer Institute (NCI)
NRG Oncology
Investigators
Principal Investigator: Cristina P. Rodriguez, MD OHSU Knight Cancer Institute

Responsible Party: Radiation Therapy Oncology Group
ClinicalTrials.gov Identifier: NCT01220583     History of Changes
Other Study ID Numbers: RTOG-1008
CDR0000686072
NCI-2013-00370
First Posted: October 14, 2010    Key Record Dates
Last Update Posted: August 31, 2018
Last Verified: August 2018

Keywords provided by Radiation Therapy Oncology Group:
stage I salivary gland cancer
stage II salivary gland cancer
stage III salivary gland cancer
high-grade salivary gland mucoepidermoid carcinoma
salivary gland adenocarcinoma
stage IVA salivary gland cancer
stage IVB salivary gland cancer
stage IVC salivary gland cancer

Additional relevant MeSH terms:
Head and Neck Neoplasms
Salivary Gland Neoplasms
Neoplasms by Site
Neoplasms
Mouth Neoplasms
Mouth Diseases
Stomatognathic Diseases
Salivary Gland Diseases
Cisplatin
Antineoplastic Agents