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Efficacy and Safety of Aliskiren and Aliskiren/Enalapril Combination on Morbidity-mortality in Patients With Chronic Heart Failure (ATMOSPHERE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00853658
Recruitment Status : Completed
First Posted : March 2, 2009
Results First Posted : November 25, 2016
Last Update Posted : November 25, 2016
Sponsor:
Information provided by (Responsible Party):
Novartis ( Novartis Pharmaceuticals )

Brief Summary:
The study will evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy as compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV.

Condition or disease Intervention/treatment Phase
Chronic Heart Failure Drug: Enalapril Drug: Aliskiren Phase 3

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 7064 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Official Title: A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of Both Aliskiren Monotherapy and Aliskiren/Enalapril Combination Therapy Compared to Enalapril Monotherapy, on Morbidity and Mortality in Patients With Chronic Heart Failure (NYHA Class II - IV). The Study is Also Known as Aliskiren Trial of Minimizing OutcomeS in Patients With HEart Failure (ATMOSPHERE).
Study Start Date : March 2009
Actual Primary Completion Date : October 2015
Actual Study Completion Date : October 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Failure

Arm Intervention/treatment
Experimental: Combination Aliskiren / Enalapril
Aliskiren / Enalapril combination therapy-150 mg/10 mg titrated to 300 mg/ 10 mg film-coated tablets and administered orally.
Drug: Enalapril
Enalapril 10 mg film-coated tablet and administered orally.

Drug: Aliskiren
Aliskiren 150 mg titrated to 300 mg film-coated tablet and administered orally.
Other Name: SPP100

Experimental: Aliskiren
Aliskiren monotherapy - 150 mg titrated to 300 mg film-coated tablets and administered orally.
Drug: Aliskiren
Aliskiren 150 mg titrated to 300 mg film-coated tablet and administered orally.
Other Name: SPP100

Active Comparator: Enalapril
Enalapril monotherapy -10 mg film-coated tablet and administered orally.
Drug: Enalapril
Enalapril 10 mg film-coated tablet and administered orally.




Primary Outcome Measures :
  1. Number of Participants That Had First Occurrence of the Composite Endpoint, Which is Defined as Either Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization [ Time Frame: up to End of Study (78 months) ]
    Number of participants that had first occurrence of the composite endpoint, which is defined as either CV death or HF hospitalization due to HF.


Secondary Outcome Measures :
  1. Change From Baseline to Month 12 for the Kansas City Cardiomyopathy Questionnaire (KCCQ) Clinical Summary Score [ Time Frame: Baseline, Month 12 ]
    Change from baseline to Month 12 for the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. KCCQ is a 23-item, self-administered instrument that quantifies physical function, symptoms (frequency, severity and recent change), social function, self-efficacy and knowledge, and quality of life. KCCQ clinical summary score is a composite assessment of physical limitations and total symptom scores. Scores are transformed to a range of 0-100, in which higher scores reflect better health status.

  2. All Cause Death [ Time Frame: up to end of study (78 months) ]
    Number of patients - All-cause death. All-cause death is common in Heart Failure HF patients this measures how many patients had this event.



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria

Patients eligible for inclusion in this study had to fulfill all of the following criteria:

  1. Patients ≥ 18 years of age, male or female.
  2. Patients with a diagnosis of chronic heart failure (NYHA

    Class II - IV):

    1. LVEF ≤ 35% at Visit 1 (local measurement, within the past 6 months assessed by echocardiography, multiple uptake gated acquisition scan (MUGA), computerized tomography(CT) scan, magnetic resonance imaging (MRI) or ventricular angiography)
    2. Elevated BNP or NT-proBNP at Visit 1:

    BNP ≥ 150 pg/mL (or BNP ≥ 100 pg/mL and unplanned hospitalization for HF within the last 12 months prior to Visit 1) (according to local measurement). OR NT-proBNP ≥ 600 pg/mL (or NT-proBNP ≥ 400 pg/mL and unplanned hospitalization for HF within the last 12 months prior to Visit 1) (according to local measurement).

  3. Patients had to be treated with an ACEI at a stable dose enalapril 10 mg daily at least or any other ACEI, e.g. ramipril, quinapril, lisinopril, fosinopril, perindopril, trandolapril; based on equivalent doses, for at least 4 weeks prior to Visit 1
  4. Patients had to be treated with a beta-blocker, unless contraindicated or not tolerated, at a stable dose for at least 4 weeks prior to visit 1 (for patients not on target dose, according to local guidelines, or in absence of that medication, the reason should be documented).
  5. Written informed consent to participate in the study and ability to comply with all requirements.

Exclusion Criteria

Patients with any of the following were to be excluded from participation in the study:

  1. History of hypersensitivity to any of the study drugs including history or allergy to ACEIs as well as known or suspected contraindications to the study drugs or previous history of intolerance to high doses of ACEIs during up- titration process.
  2. Patients treated concomitantly with both an ARB and an aldosterone antagonist in addition to study drug at Visit 1.
  3. Current acute decompensated HF (defined as an acute exacerbation of a chronic heart failure status manifested by typical signs and symptoms of HF like dyspnea, fatigue etc., that may require IV therapy with diuretics, vasodilators and/or inotropic drugs).
  4. Symptomatic hypotension and/or less than 95 mmHg systolic blood pressure (SBP) at Visit 1 and/or less than 90 mmHg SBP at Visit 4.
  5. Acute coronary syndrome, stroke, transient ischemic attack, cardiac, carotid or major vascular surgery, percutaneous coronary intervention (PCI) or carotid angioplasty, within the past 3 months prior to Visit 1.
  6. Coronary or carotid artery disease likely to require surgical or percutaneous intervention within the 6 months after Visit 1.
  7. Right heart failure due to severe pulmonary disease.
  8. Patients with Diabetes Mellitus.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00853658


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United States, Alabama
Novartis Investigative Site
Huntsville, Alabama, United States, 35801
Novartis Investigative Site
Mobile, Alabama, United States, 36608
Novartis Investigative Site
Mobile, Alabama, United States, 36693
United States, Arizona
Novartis Investigative Site
Tucson, Arizona, United States, 85723-0001
United States, Arkansas
Novartis Investigative Site
Hot Springs, Arkansas, United States, 71913
Novartis Investigative Site
Little Rock, Arkansas, United States, 72204
Novartis Investigative Site
Little Rock, Arkansas, United States, 72205
Novartis Investigative Site
Pine Bluff, Arkansas, United States, 71603
Novartis Investigative Site
Searcy, Arkansas, United States, 72143
United States, California
Novartis Investigative Site
Beverly Hills, California, United States, 90211
Novartis Investigative Site
French Camp, California, United States, 95231
Novartis Investigative Site
Inglewood, California, United States, 90301
Novartis Investigative Site
Los Angeles, California, United States, 90073
Novartis Investigative Site
Modesto, California, United States, 95355
Novartis Investigative Site
Northridge, California, United States, 91325
Novartis Investigative Site
Sacramento, California, United States, 95825
Novartis Investigative Site
San Diego, California, United States, 92123
Novartis Investigative Site
Santa Monica, California, United States, 90404
Novartis Investigative Site
Westlake Village, California, United States, 91361
United States, Colorado
Novartis Investigative Site
Denver, Colorado, United States, 80218
Novartis Investigative Site
Littleton, Colorado, United States, 80120
United States, Florida
Novartis Investigative Site
Boynton Beach, Florida, United States, 33437
Novartis Investigative Site
Daytona Beach, Florida, United States, 32117
Novartis Investigative Site
Fort Lauderdale, Florida, United States, 33316
Novartis Investigative Site
Hollywood, Florida, United States, 33021
Novartis Investigative Site
Jacksonville Beach, Florida, United States, 32050
Novartis Investigative Site
Miami Lakes, Florida, United States, 33014
Novartis Investigative Site
Orlando, Florida, United States, 32803
Novartis Investigative Site
Wellington, Florida, United States, 33449
United States, Georgia
Novartis Investigative Site
Athens, Georgia, United States, 30606
Novartis Investigative Site
Augusta, Georgia, United States, 30904
United States, Illinois
Novartis Investigative Site
Gillespie, Illinois, United States, 62033
United States, Kansas
Novartis Investigative Site
Topeka, Kansas, United States, 66606
United States, Louisiana
Novartis Investigative Site
Metairie, Louisiana, United States, 70006
Novartis Investigative Site
New Orleans, Louisiana, United States, 70121
Novartis Investigative Site
Slidell, Louisiana, United States, 70458
United States, Maine
Novartis Investigative Site
Auburn, Maine, United States, 04210
United States, Michigan
Novartis Investigative Site
Southfield, Michigan, United States, 48075
United States, Missouri
Novartis Investigative Site
St. Louis, Missouri, United States, 63110
United States, Nebraska
Novartis Investigative Site
Lincoln, Nebraska, United States, 68506
Novartis Investigative Site
Omaha, Nebraska, United States, 68198
United States, New Jersey
Novartis Investigative Site
Elmer, New Jersey, United States, 08318
United States, New York
Novartis Investigative Site
Laurelton, New York, United States, 11422
Novartis Investigative Site
Stony Brook, New York, United States, 11794
Novartis Investigative Site
Wiliamsville, New York, United States, 14221
United States, North Carolina
Novartis Investigative Site
Durham, North Carolina, United States, 27710
United States, Ohio
Novartis Investigative Site
Marion, Ohio, United States, 43302
United States, South Carolina
Novartis Investigative Site
Charleston, South Carolina, United States, 29403
Novartis Investigative Site
Varnville, South Carolina, United States, 29944
United States, Tennessee
Novartis Investigative Site
Germantown, Tennessee, United States, 38138
Novartis Investigative Site
Memphis, Tennessee, United States, 38120
Novartis Investigative Site
Nashville, Tennessee, United States, 37205
Novartis Investigative Site
Nashville, Tennessee, United States, 37212
United States, Texas
Novartis Investigative Site
Dallas, Texas, United States, 75226
Novartis Investigative Site
Houston, Texas, United States, 77021
Novartis Investigative Site
Houston, Texas, United States, 77030
United States, Washington
Novartis Investigative Site
Everett, Washington, United States, 98208
Novartis Investigative Site
Kirkland, Washington, United States, 98034
Argentina
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Bahia Blanca, Buenos Aires, Argentina, 8000
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1180AAX
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1408INH
Novartis Investigative Site
Caba, Buenos Aires, Argentina, C1416DRJ
Novartis Investigative Site
Coronel Suarez, Buenos Aires, Argentina, B7540GHD
Novartis Investigative Site
La Plata, Buenos Aires, Argentina, 1900
Novartis Investigative Site
Quilmes, Buenos Aires, Argentina, B1878GEG
Novartis Investigative Site
Ramos Mejia, Buenos Aires, Argentina, B1704ETD
Novartis Investigative Site
San Isidro, Buenos Aires, Argentina, B1642DCD
Novartis Investigative Site
San Nicolas, Buenos Aires, Argentina, B2900DMH
Novartis Investigative Site
Córdoba, Cordoba, Argentina, X5152HQC
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Va Allende, Cordoba, Argentina, 5105
Novartis Investigative Site
Villa Maria, Cordoba, Argentina, X5220XAO
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Posadas, Misiones, Argentina, N3300AHX
Novartis Investigative Site
Tucuman, San Miguel de Tucuman, Argentina, T4000ICL
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2000CXH
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2000DFD
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2000DSV
Novartis Investigative Site
Rosario, Santa Fe, Argentina, S2001ODA
Novartis Investigative Site
San Miguel de Tucuman, Tucuman, Argentina, T4000IFL
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Buenos Aires, Argentina, C1094AAD
Novartis Investigative Site
Buenos Aires, Argentina, C1428DCO
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Cordoba, Argentina, X5000AAI
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Cordoba, Argentina, X5000AVI
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Cordoba, Argentina, X5000EPU
Novartis Investigative Site
Cordoba, Argentina, X5000EVQ
Novartis Investigative Site
Cordoba, Argentina, X5000FGG
Novartis Investigative Site
Cordoba, Argentina, X5002AOQ
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Cordoba, Argentina, X5003DCE
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Cordoba, Argentina, X5004BAL
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Cordoba, Argentina, X5006IKK
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Cordoba, Argentina, X5009BSN
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Cordoba, Argentina, X5022CPU
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Cordoba, Argentina, X5220XAO
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Corrientes, Argentina, W3400CBI
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Corrientes, Argentina, W3400
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Salta, Argentina, 4400
Australia, Australian Capital Territory
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Canberra, Australian Capital Territory, Australia, 2605
Australia, New South Wales
Novartis Investigative Site
Darlinghurst, New South Wales, Australia, 2010
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Kingswood, New South Wales, Australia, 2747
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Wollongong, New South Wales, Australia, 2500
Australia, Queensland
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Auchenflower, Queensland, Australia, 4066
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Woolloongabba, Queensland, Australia, 4101
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Wooloongabba, Queensland, Australia, 4102
Australia, South Australia
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Bedford Park, South Australia, Australia, 5042
Australia, Tasmania
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Launceston, Tasmania, Australia, 7250
Australia, Victoria
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Geelong, Victoria, Australia, 3220
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Prahran, Victoria, Australia, 3181
Austria
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Innsbruck, Tyrol, Austria, 6020
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Graz, Austria, A-8036
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Linz, Austria, 4010
Novartis Investigative Site
Linz, Austria, A-4010
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Salzburg, Austria, A-5020
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Vienna, Austria, 1030
Novartis Investigative Site
Vienna, Austria, 1140
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Wien, Austria, A-1090
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Wien, Austria, A-1160
Belgium
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Anderlecht, Belgium, 1070
Novartis Investigative Site
Brugge, Belgium, 8000
Novartis Investigative Site
Brussels, Belgium, 1180
Novartis Investigative Site
Bruxelles, Belgium, 1200
Novartis Investigative Site
De Pinte, Belgium, 9840
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Eupen, Belgium, 4700
Novartis Investigative Site
Genk, Belgium, 3600
Novartis Investigative Site
Huy, Belgium, 4500
Novartis Investigative Site
Ieper, Belgium, 8900
Novartis Investigative Site
Leuven, Belgium, 3000
Novartis Investigative Site
Liege, Belgium, 4000
Novartis Investigative Site
Turnhout, Belgium, 2300
Brazil
Novartis Investigative Site
Fortaleza, CE, Brazil, 60864-190
Novartis Investigative Site
Brasilia, DF, Brazil, 70658-700
Novartis Investigative Site
Goiania, GO, Brazil, 74605-050
Novartis Investigative Site
Belo Horizonte, MG, Brazil, 30110-934
Novartis Investigative Site
Belo Horizonte, MG, Brazil
Novartis Investigative Site
Recife, PE, Brazil, 50100-060
Novartis Investigative Site
Campina Grande do Sul, PR, Brazil, 83430-000
Novartis Investigative Site
Curitiba, PR, Brazil, 80010-030
Novartis Investigative Site
Londrina, PR, Brazil, 86051-990
Novartis Investigative Site
Rio de Janeiro, RJ, Brazil, 22240-006
Novartis Investigative Site
Caxias do Sul, RS, Brazil, 95070-560
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90020-090
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90035-903
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90560-030
Novartis Investigative Site
Porto Alegre, RS, Brazil, 90610-000
Novartis Investigative Site
Campinas, SP, Brazil, 13020-431
Novartis Investigative Site
Campinas, SP, Brazil, 13060-904
Novartis Investigative Site
Campinas, SP, Brazil, 13083-190
Novartis Investigative Site
Marilia, SP, Brazil, 17519-030
Novartis Investigative Site
São Paulo, SP, Brazil, 05403-900
Novartis Investigative Site
Tatuí, SP, Brazil, 18270-170
Canada, Alberta
Novartis Investigative Site
Calgary, Alberta, Canada, T2N 4Z6
Canada, New Brunswick
Novartis Investigative Site
St. John, New Brunswick, Canada, E2L 4L2
Canada, Ontario
Novartis Investigative Site
Brampton, Ontario, Canada, L6Z 4N5
Novartis Investigative Site
Cambridge, Ontario, Canada, N1R 6V6
Novartis Investigative Site
Ottawa, Ontario, Canada, K1Y 4W7
Canada, Quebec
Novartis Investigative Site
Joliette, Quebec, Canada, J6E 6J2
Novartis Investigative Site
Montreal, Quebec, Canada, H1T 1C8
Novartis Investigative Site
Montreal, Quebec, Canada, H1T 3Y7
Novartis Investigative Site
Québec, Quebec, Canada, G1J 1Z6
Novartis Investigative Site
Sainte-Foy, Quebec, Canada, G1V 4G5
China, Beijing
Novartis Investigative Site
Beijing, Beijing, China, 100083
Novartis Investigative Site
Beijing, Beijing, China, 100088
Novartis Investigative Site
Beijing, Beijing, China, 100730
China, Fujian
Novartis Investigative Site
Fuzhou, Fujian, China, 350001
China, Guangdong
Novartis Investigative Site
Guangzhou, Guangdong, China, 510080
Novartis Investigative Site
Guangzhou, Guangdong, China, 510515
China, Hebei
Novartis Investigative Site
Shijiazhuang, Hebei, China, 050000
China, Hubei
Novartis Investigative Site
Wuhan, Hubei, China, 430022
China, Jiangsu
Novartis Investigative Site
Nanjing, Jiangsu, China
Novartis Investigative Site
Suzhou, Jiangsu, China, 215004
China, Jilin
Novartis Investigative Site
Changchun, Jilin, China, 130021
China, Liaoning
Novartis Investigative Site
Shenyang, Liaoning, China, 110003
Novartis Investigative Site
Shenyang, Liaoning, China, 110016
China, Shanghai
Novartis Investigative Site
Shanghai, Shanghai, China, 200011
China, Tianjin
Novartis Investigative Site
Tianjin, Tianjin, China, 300121
China, Zhejiang
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310006
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310009
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310013
Novartis Investigative Site
Hangzhou, Zhejiang, China, 310016
China
Novartis Investigative Site
Baotou, China, 014040
Novartis Investigative Site
Beijing, China, 100020
Novartis Investigative Site
Beijing, China, 100028
Novartis Investigative Site
Beijing, China, 100029
Novartis Investigative Site
Beijing, China, 100034
Novartis Investigative Site
Beijing, China, 100044
Novartis Investigative Site
Beijing, China, 100050
Novartis Investigative Site
Guang zhou, China, 510080
Novartis Investigative Site
Jinan, China, 250012
Novartis Investigative Site
Shanghai, China, 200025
Novartis Investigative Site
Shanghai, China, 200032
Novartis Investigative Site
Shanghai, China, 200233
Novartis Investigative Site
Tianjin, China, 300142
Novartis Investigative Site
Xian, China, 710004
Colombia
Novartis Investigative Site
Medellín, Antioquia, Colombia
Novartis Investigative Site
Baranquilla, Atlantico, Colombia
Novartis Investigative Site
Barranquilla, Atlantico, Colombia
Novartis Investigative Site
Cartagena, Bolivar, Colombia
Novartis Investigative Site
Bogota, Cundinamarca, Colombia, 111411
Novartis Investigative Site
Bogotá, Cundinamarca, Colombia, 110111
Novartis Investigative Site
Barranquilla, Colombia
Novartis Investigative Site
Bogotá, Colombia, 00000
Novartis Investigative Site
Bogotá, Colombia
Novartis Investigative Site
Florida Blanca, Colombia
Novartis Investigative Site
Medellín, Colombia
Costa Rica
Novartis Investigative Site
Goicoechea, San Jose, Costa Rica, Costa Rica, 3184-1000
Novartis Investigative Site
Alajuela, Costa Rica
Novartis Investigative Site
San Jose, Costa Rica, 1307-1000
Novartis Investigative Site
San Jose, Costa Rica, 272-1225
Czech Republic
Novartis Investigative Site
Benesov, Czech Republic, 25601
Novartis Investigative Site
Brno, Czech Republic, 60200
Novartis Investigative Site
Cesky Krumlov, Czech Republic, 381 01
Novartis Investigative Site
Jindrichuv Hradec, Czech Republic, 377 01
Novartis Investigative Site
Kolín, Czech Republic, 280 02
Novartis Investigative Site
Kromeriz, Czech Republic, 767 01
Novartis Investigative Site
Louny, Czech Republic, 440 01
Novartis Investigative Site
Louny, Czech Republic
Novartis Investigative Site
Marianske lazne, Czech Republic, 353 01
Novartis Investigative Site
Ostrava, Czech Republic, 70200
Novartis Investigative Site
Plzen, Czech Republic, 323 00
Novartis Investigative Site
Praha 11, Czech Republic, 148 00
Novartis Investigative Site
Praha 2, Czech Republic, 128 08
Novartis Investigative Site
Praha 9, Czech Republic
Novartis Investigative Site
Pribram VIII, Czech Republic, 261 01
Novartis Investigative Site
Teplice, Czech Republic, 415 01
Novartis Investigative Site
Vyskov, Czech Republic, 68001
Denmark
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Aalborg, Denmark, DK-9000
Novartis Investigative Site
Copenhagen NV, Denmark, DK-2400
Novartis Investigative Site
Copenhagen S, Denmark, DK-2300
Novartis Investigative Site
Copenhagen, Denmark, 2100
Novartis Investigative Site
Esbjerg, Denmark, DK-6700
Novartis Investigative Site
Fredericia, Denmark, 7000
Novartis Investigative Site
Frederiksberg, Denmark, DK-2000
Novartis Investigative Site
Glostrup, Denmark, DK-2600
Novartis Investigative Site
Hellerup, Denmark, DK-2900
Novartis Investigative Site
Helsingoer, Denmark, DK-3000
Novartis Investigative Site
Hillerød, Denmark, DK-3400
Novartis Investigative Site
Hjørring, Denmark, DK-9800
Novartis Investigative Site
Holbæk, Denmark, DK-4300
Novartis Investigative Site
Hvidovre, Denmark, DK-2650
Novartis Investigative Site
Køge, Denmark, DK-4600
Novartis Investigative Site
Næstved, Denmark, DK-4700
Novartis Investigative Site
Odense C, Denmark, DK-5000
Novartis Investigative Site
Randers NØ, Denmark, DK-8930
Novartis Investigative Site
Silkeborg, Denmark, 8600
Novartis Investigative Site
Svendborg, Denmark, DK-5700
Novartis Investigative Site
Viborg, Denmark, DK-8800
Novartis Investigative Site
Århus N, Denmark, DK-8200
Dominican Republic
Novartis Investigative Site
Santo Domingo, Republica Dominicana, Dominican Republic
Novartis Investigative Site
San Cristobal, Dominican Republic
Estonia
Novartis Investigative Site
Parnu, Estonia, 80010
Novartis Investigative Site
Tallinn, Estonia, 10138
Novartis Investigative Site
Tallinn, Estonia, 13419
Novartis Investigative Site
Tartu, Estonia, 51014
Finland
Novartis Investigative Site
Hyvinkää, Finland, FIN-05850
Novartis Investigative Site
Jyvaskyla, Finland, FIN-40620
Novartis Investigative Site
Seinajoki, Finland, 60200
Novartis Investigative Site
Tammisaari, Finland, 10600
Novartis Investigative Site
Turku, Finland, FIN-20520
France
Novartis Investigative Site
Albi, France, 81013
Novartis Investigative Site
Angers, France, 49000
Novartis Investigative Site
Becon Les Granits, France, 49370
Novartis Investigative Site
Clichy, France, 92110
Novartis Investigative Site
Dijon, France, 21079
Novartis Investigative Site
Grenoble, France, 38043
Novartis Investigative Site
Marseille Cedex 05, France, 13385
Novartis Investigative Site
Marseille, France, 13915
Novartis Investigative Site
Paris, France, 75013
Novartis Investigative Site
Paris, France, 75571
Novartis Investigative Site
Pessac Cedex, France, 33604
Novartis Investigative Site
Saint-Etienne, France, 42055
Novartis Investigative Site
Vandoeuvre Les Nancy, France, 54511
Germany
Novartis Investigative Site
Winsen (Luhe), Lower Saxony, Germany, 21423
Novartis Investigative Site
Augsburg, Germany, 86150
Novartis Investigative Site
Bad Nauheim, Germany, 61231
Novartis Investigative Site
Bad Neustadt an der Saale, Germany, 97616
Novartis Investigative Site
Bensheim, Germany, 64625
Novartis Investigative Site
Berlin, Germany, 10367
Novartis Investigative Site
Berlin, Germany, 10789
Novartis Investigative Site
Berlin, Germany, 12163
Novartis Investigative Site
Berlin, Germany, 12351
Novartis Investigative Site
Berlin, Germany, 12552
Novartis Investigative Site
Berlin, Germany, 13353
Novartis Investigative Site
Berlin, Germany, 13405
Novartis Investigative Site
Bochum, Germany, 44791
Novartis Investigative Site
Bonn, Germany, 53115
Novartis Investigative Site
Bonn, Germany, 53127
Novartis Investigative Site
Bonn, Germany, 53225
Novartis Investigative Site
Brake, Germany, 26919
Novartis Investigative Site
Celle, Germany, 29223
Novartis Investigative Site
Chemnitz, Germany, 09113
Novartis Investigative Site
Chemnitz, Germany, 09116
Novartis Investigative Site
Chemnitz, Germany, 09126
Novartis Investigative Site
Coburg, Germany, 96450
Novartis Investigative Site
Darmstadt, Germany, 64283
Novartis Investigative Site
Dessau-Roßlau, Germany, 06846
Novartis Investigative Site
Dinkelsbühl, Germany, 91550
Novartis Investigative Site
Dorsten, Germany, 46282
Novartis Investigative Site
Dortmund, Germany, 44137
Novartis Investigative Site
Dresden, Germany, 01067
Novartis Investigative Site
Dresden, Germany, 01097
Novartis Investigative Site
Dresden, Germany, 01219
Novartis Investigative Site
Dresden, Germany, 01277
Novartis Investigative Site
Dresden, Germany, 01309
Novartis Investigative Site
Duisburg, Germany, 47051
Novartis Investigative Site
Duisburg, Germany, 47139
Novartis Investigative Site
Düsseldorf, Germany, 40593
Novartis Investigative Site
Ebersbach, Germany, 02730
Novartis Investigative Site
Erfurt, Germany, 99084
Novartis Investigative Site
Erkner, Germany, 15537
Novartis Investigative Site
Essen, Germany, 45136
Novartis Investigative Site
Essen, Germany, 45355
Novartis Investigative Site
Frankfurt, Germany, 60594
Novartis Investigative Site
Goettingen, Germany, 37075
Novartis Investigative Site
Gotha, Germany, 99867
Novartis Investigative Site
Göttingen, Germany, 37073
Novartis Investigative Site
Gütersloh, Germany, 33332
Novartis Investigative Site
Halle (Saale), Germany, 06120
Novartis Investigative Site
Halle/Saale, Germany, 06120
Novartis Investigative Site
Hamburg, Germany, 20099
Novartis Investigative Site
Hannover, Germany, 30167
Novartis Investigative Site
Hassloch, Germany, 67454
Novartis Investigative Site
Heidelberg, Germany, 69115
Novartis Investigative Site
Heidelberg, Germany, 69120
Novartis Investigative Site
Heilbronn, Germany, 74078
Novartis Investigative Site
Helmbrechts, Germany, 95223
Novartis Investigative Site
Heppenheim, Germany, 64646
Novartis Investigative Site
Kassel, Germany, 34127
Novartis Investigative Site
Kleve, Germany, 47533
Novartis Investigative Site
Koblenz, Germany, 56068
Novartis Investigative Site
Krefeld, Germany, 47798
Novartis Investigative Site
Köln, Germany, 51605
Novartis Investigative Site
Königsbrück, Germany, 01436
Novartis Investigative Site
Köthen, Germany, 06366
Novartis Investigative Site
Lambrecht, Germany, 67466
Novartis Investigative Site
Landshut, Germany, 84034
Novartis Investigative Site
Leipzig, Germany, 04177
Novartis Investigative Site
Lichtentanne, Germany, 08115
Novartis Investigative Site
Lienen, Germany, 49536
Novartis Investigative Site
Ludwigsburg, Germany, 71634
Novartis Investigative Site
Lörrach, Germany, 79539
Novartis Investigative Site
Lüneburg, Germany, 21339
Novartis Investigative Site
Magdeburg, Germany, 39110
Novartis Investigative Site
Mainz, Germany, 55116
Novartis Investigative Site
Markkleeberg, Germany, 04416
Novartis Investigative Site
Mayen, Germany, 56727
Novartis Investigative Site
Melsungen, Germany, 34212
Novartis Investigative Site
Muehldorf am Inn, Germany, 84453
Novartis Investigative Site
Muehlheim an der Ruhr, Germany, 45468
Novartis Investigative Site
Muenchen, Germany, 80636
Novartis Investigative Site
Mülheim, Germany, 45468
Novartis Investigative Site
Northeim, Germany, 37154
Novartis Investigative Site
Nürnberg, Germany, 90471
Novartis Investigative Site
Oelde, Germany, 59302
Novartis Investigative Site
Oelde, Germany, 59303
Novartis Investigative Site
Pirna, Germany, 01796
Novartis Investigative Site
Potsdam, Germany, 14471
Novartis Investigative Site
Reinfeld, Germany, 23858
Novartis Investigative Site
Salzwedel, Germany, 29410
Novartis Investigative Site
Schwalmstadt, Germany, 34613
Novartis Investigative Site
Schwäbisch Hall, Germany, 74523
Novartis Investigative Site
Siegen, Germany, 57072
Novartis Investigative Site
Solingen, Germany, 42651
Novartis Investigative Site
Stade, Germany, 21682
Novartis Investigative Site
Stuttgart, Germany, 70372
Novartis Investigative Site
Stuttgart, Germany, 70378
Novartis Investigative Site
Wedel, Germany, 22880
Novartis Investigative Site
Witten, Germany, 58455
Novartis Investigative Site
Wuerzburg, Germany, 97078
Novartis Investigative Site
Zwickau, Germany, 08056
Greece
Novartis Investigative Site
Athens, GR, Greece, 115 27
Novartis Investigative Site
Thessaloniki, GR, Greece, 546 36
Novartis Investigative Site
Thessaloniki, GR, Greece, 570 10
Novartis Investigative Site
Athens, Greece, 115 28
Novartis Investigative Site
Athens, Greece, 124 62
Novartis Investigative Site
Athens, Greece, GR 11527
Novartis Investigative Site
Chios, Greece, 82100
Novartis Investigative Site
Edessa, Greece, 58200
India
Novartis Investigative Site
Guntur, Andhra Pradesh, India, 522001
Novartis Investigative Site
Hyderabad, Andhra Pradesh, India, 500012
Novartis Investigative Site
Secunderabad, Andhra Pradesh, India, 500003
Novartis Investigative Site
Vijayawada, Andhra Pradesh, India, 520 008
Novartis Investigative Site
New Delhi, Delhi, India, 110060
Novartis Investigative Site
Ahmedabad, Gujarat, India, 380 051
Novartis Investigative Site
Bangalore, Karnataka, India, 560 052
Novartis Investigative Site
Bangalore, Karnataka, India, 560099
Novartis Investigative Site
Manipal, Karnataka, India, 576104
Novartis Investigative Site
Trivandrum, Kerela, India, 695002
Novartis Investigative Site
Mumbai, Maharashtra, India, 400 022
Novartis Investigative Site
Nagpur, Maharashtra, India, 400 008
Novartis Investigative Site
Nagpur, Maharashtra, India, 400 012
Novartis Investigative Site
Nagpur, Maharashtra, India, 400012
Novartis Investigative Site
Nagpur, Maharashtra, India, 440 010
Novartis Investigative Site
Nagpur, Maharashtra, India, 440010
Novartis Investigative Site
Nagpur, Maharashtra, India, 440012
Novartis Investigative Site
Pune, Maharashtra, India, 411 011
Novartis Investigative Site
Pune, Maharashtra, India, 411 019
Novartis Investigative Site
Pune, Maharashtra, India, 411 044
Novartis Investigative Site
Pune, Maharashtra, India, 411004
Novartis Investigative Site
Pune, Maharashtra, India, 411011
Novartis Investigative Site
Delhi, New Delhi, India, 110065
Novartis Investigative Site
Jaipur, Rajasthan, India, 302001
Novartis Investigative Site
Jaipur, Rajasthan, India, 302024
Novartis Investigative Site
Chennai, Tamil Nadu, India, 600100
Novartis Investigative Site
Coimbatore, Tamil Nadu, India, 641014
Novartis Investigative Site
Madurai, Tamil Nadu, India, 625107
Novartis Investigative Site
Hyderabad, Telangana, India, 500082
Novartis Investigative Site
Lucknow, Uttar Pradesh, India, 226005
Novartis Investigative Site
Lucknow, Uttar Pradesh, India, 226014
Novartis Investigative Site
Bangalore, India, 560 034
Novartis Investigative Site
Hyderabad, India, 500 063
Novartis Investigative Site
Hyderabad, India, 500044
Novartis Investigative Site
Lucknow, India, 226003
Novartis Investigative Site
Mumbai, India, 400 050
Novartis Investigative Site
New Delhi, India, 110044
Novartis Investigative Site
Noida, India, 201301
Ireland
Novartis Investigative Site
Co Dublin, Ireland
Novartis Investigative Site
Dublin 7, Ireland
Novartis Investigative Site
Dublin, Ireland, 9
Novartis Investigative Site
Dublin, Ireland
Novartis Investigative Site
Galway, Ireland
Italy
Novartis Investigative Site
Montescano, (pv), Italy, 27040
Novartis Investigative Site
Pavia, (pv), Italy, 27100
Novartis Investigative Site
Ancona, AN, Italy, 60126
Novartis Investigative Site
Arezzo, AR, Italy, 52100
Novartis Investigative Site
Cortona, AR, Italy, 52044
Novartis Investigative Site
Bergamo, BG, Italy, 24128
Novartis Investigative Site
Bologna, BO, Italy, 40138
Novartis Investigative Site
Brescia, BS, Italy, 25123
Novartis Investigative Site
Lumezzane, BS, Italy, 25065
Novartis Investigative Site
Chieti, CH, Italy, 66100
Novartis Investigative Site
Cosenza, CS, Italy, 87100
Novartis Investigative Site
Forlì, FC, Italy, 47100
Novartis Investigative Site
Cona, FE, Italy, 44100
Novartis Investigative Site
Foggia, FG, Italy, 71100
Novartis Investigative Site
Firenze, FI, Italy, 50143
Novartis Investigative Site
Pozzilli, IS, Italy, 86077
Novartis Investigative Site
Casarano, LE, Italy, 73042
Novartis Investigative Site
Cecina, LI, Italy, 57023
Novartis Investigative Site
Castelnuovo di Garfagnana, LU, Italy, 55032
Novartis Investigative Site
Milano, MI, Italy, 20132
Novartis Investigative Site
Milano, MI, Italy, 20138
Novartis Investigative Site
Passirana di Rho, MI, Italy, 20017
Novartis Investigative Site
Pieve di Coriano, MN, Italy
Novartis Investigative Site
Massa, MS, Italy, 54100
Novartis Investigative Site
Palermo, PA, Italy, 90127
Novartis Investigative Site
Perugia, PG, Italy, 06129
Novartis Investigative Site
Parma, PR, Italy, 43100
Novartis Investigative Site
Pavia, PV, Italy, 27100
Novartis Investigative Site
Cotignola, RA, Italy, 48010
Novartis Investigative Site
Roma, RM, Italy, 00169
Novartis Investigative Site
Roma, RM, Italy, 00184
Novartis Investigative Site
Roma, RM, Italy, 00189
Novartis Investigative Site
Rimini, RN, Italy, 47900
Novartis Investigative Site
Cava De' Tirreni, SA, Italy, 84013
Novartis Investigative Site
Poggibonsi, SI, Italy, 53036
Novartis Investigative Site
Sondalo, SO, Italy, 23035
Novartis Investigative Site
Sarzana, SP, Italy, 19038
Novartis Investigative Site
Sassari, SS, Italy, 07100
Novartis Investigative Site
Orbassano, TO, Italy, 10043
Novartis Investigative Site
Torino, TO, Italy, 10126
Novartis Investigative Site
Terni, TR, Italy, 05100
Novartis Investigative Site
Trieste, TS, Italy, 34142
Novartis Investigative Site
Trieste, TS, Italy, 34149
Novartis Investigative Site
Vittorio Veneto, TV, Italy, 31029
Novartis Investigative Site
San Daniele Del Friuli, UD, Italy, 33038
Novartis Investigative Site
Udine, UD, Italy, 33100
Novartis Investigative Site
Tradate, VA, Italy, 21049
Novartis Investigative Site
San Bonifacio, VR, Italy, 37047
Japan
Novartis Investigative Site
Nagoya-city, Aichi, Japan, 466-8560
Novartis Investigative Site
Seto-city, Aichi, Japan, 489-8642
Novartis Investigative Site
Chiba-city, Chiba, Japan, 260-8677
Novartis Investigative Site
Inba-gun, Chiba, Japan, 270-1694
Novartis Investigative Site
Chikushino-city, Fukuoka, Japan, 818-8502
Novartis Investigative Site
Fukuoka-city, Fukuoka, Japan, 814-0180
Novartis Investigative Site
Iizuka-city, Fukuoka, Japan, 820-8505
Novartis Investigative Site
Kurume-city, Fukuoka, Japan, 830-8577
Novartis Investigative Site
Ogaki-city, Gifu, Japan, 503-8502
Novartis Investigative Site
Hiroshima-city, Hiroshima, Japan, 734-8551
Novartis Investigative Site
Kure, Hiroshima, Japan, 737-0023
Novartis Investigative Site
Sapporo-city, Hokkaido, Japan, 060-8648
Novartis Investigative Site
Sapporo-city, Hokkaido, Japan, 063-0005
Novartis Investigative Site
Amagasaki-city, Hyogo, Japan, 660-8550
Novartis Investigative Site
Higashiibaraki-gun, Ibaraki, Japan, 311-3193
Novartis Investigative Site
Hitachinaka, Ibaraki, Japan, 312-0057
Novartis Investigative Site
Tsukuba-city, Ibaraki, Japan, 305-8576
Novartis Investigative Site
Kanazawa, Ishikawa, Japan, 920-8650
Novartis Investigative Site
Kawasaki-city, Kanagawa, Japan, 210-0852
Novartis Investigative Site
Sagamihara-city, Kanagawa, Japan, 252-0375
Novartis Investigative Site
Yokohama-city, Kanagawa, Japan, 232-0024
Novartis Investigative Site
Yokosuka, Kanagawa, Japan, 238-8567
Novartis Investigative Site
Kumamoto City, Kumamoto, Japan, 860-8556
Novartis Investigative Site
Sendai-city, Miyagi, Japan, 980-8574
Novartis Investigative Site
Kashihara-city, Nara, Japan, 634-8522
Novartis Investigative Site
Okayama-city, Okayama, Japan, 702-8055
Novartis Investigative Site
Izumisano-city, Osaka, Japan, 598-8577
Novartis Investigative Site
Kita-ku, Osaka, Japan, 530-0001
Novartis Investigative Site
Osaka-city, Osaka, Japan, 545-8586
Novartis Investigative Site
Ureshino, Saga, Japan, 843-0393
Novartis Investigative Site
Hamada, Shimane, Japan, 697-8511
Novartis Investigative Site
Komatsushima-city, Tokushima, Japan, 773-8502
Novartis Investigative Site
Tokushima-city, Tokushima, Japan, 770-8503
Novartis Investigative Site
Adachi-ku, Tokyo, Japan, 120-0006
Novartis Investigative Site
Bunkyo-ku, Tokyo, Japan, 113-8431
Novartis Investigative Site
Bunkyo-ku, Tokyo, Japan, 113-8519
Novartis Investigative Site
Bunkyo-ku, Tokyo, Japan, 113-8603
Novartis Investigative Site
Bunkyo-ku, Tokyo, Japan, 113-8655
Novartis Investigative Site
Shinjuku-ku, Tokyo, Japan, 162-8666
Novartis Investigative Site
Hofu, Yamaguchi, Japan, 747-8511
Novartis Investigative Site
Shunan-city, Yamaguchi, Japan, 745-8522
Novartis Investigative Site
Ube, Yamaguchi, Japan, 755-8505
Novartis Investigative Site
Fukushima, Japan, 960-8251
Novartis Investigative Site
Nagasaki, Japan, 850-8555
Novartis Investigative Site
Saga, Japan, 849-8501
Novartis Investigative Site
Toyama, Japan, 930-0194
Korea, Republic of
Novartis Investigative Site
Seongnam, Gyeonggi, Korea, Republic of, 13620
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 03080
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 03722
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 05505
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 06351
Novartis Investigative Site
Seoul, Korea, Korea, Republic of, 152-703
Novartis Investigative Site
Busan, Korea, Republic of, 602-715
Novartis Investigative Site
Daejeon, Korea, Republic of, 302-241
Novartis Investigative Site
Gwangju, Korea, Republic of, 501-757
Novartis Investigative Site
Incheon, Korea, Republic of, 405-760
Novartis Investigative Site
Seoul, Korea, Republic of, 143-729
Novartis Investigative Site
Taegu, Korea, Republic of, 700 - 721
Latvia
Novartis Investigative Site
Daugavpils, Latvia, LV-5401
Novartis Investigative Site
Riga, Latvia, 1012
Novartis Investigative Site
Riga, Latvia, LV-1012
Novartis Investigative Site
Riga, Latvia, LV-1038
Lithuania
Novartis Investigative Site
Kaunas, LTU, Lithuania, 50009
Novartis Investigative Site
Kaunas, Lithuania, LT-47144
Novartis Investigative Site
Klaipeda, Lithuania, LT-92288
Novartis Investigative Site
Vilnius, Lithuania, 08661
Mexico
Novartis Investigative Site
Guadalajara, Jalisco, Mexico, 44600
Novartis Investigative Site
Zapopan, Jalisco, Mexico, 45200
Novartis Investigative Site
Monterrey, Nuevo León, Mexico, 64060
Novartis Investigative Site
Monterrey, Nuevo León, Mexico, 64710
Novartis Investigative Site
Culiacan, Sinaloa, Mexico, CP:83230
Novartis Investigative Site
Aguascalientes, Mexico, 20230
Novartis Investigative Site
Querétaro, Mexico, 76000
Novartis Investigative Site
San Luis Potosi, Mexico, 78200
Netherlands
Novartis Investigative Site
Alkmaar, Netherlands, 1815 JD
Novartis Investigative Site
Amsterdam, Netherlands, 1023 NL
Novartis Investigative Site
Amsterdam, Netherlands, 1061 AE
Novartis Investigative Site
Amsterdam, Netherlands, 1091 HA
Novartis Investigative Site
Amsterdam, Netherlands, 1105 AZ
Novartis Investigative Site
Apeldoorn, Netherlands, 7334 DZ
Novartis Investigative Site
Deventer, Netherlands, 7416 SE
Novartis Investigative Site
Dirksland, Netherlands, 3247 BW
Novartis Investigative Site
Enschede, Netherlands, 7513 ER
Novartis Investigative Site
Groningen, Netherlands, 9713 GZ
Novartis Investigative Site
Haarlem, Netherlands, 2035 RC
Novartis Investigative Site
Heerlen, Netherlands, 6419 PC
Novartis Investigative Site
Leeuwarden, Netherlands, 8934 AD
Novartis Investigative Site
Leiderdorp, Netherlands, NL-2353 GA
Novartis Investigative Site
Meppel, Netherlands, 7943 KA
Novartis Investigative Site
Rotterdam, Netherlands, 3045 PM
Novartis Investigative Site
Rotterdam, Netherlands, 3083 AN
Novartis Investigative Site
Venlo, Netherlands, 5912 BL
Novartis Investigative Site
Wildervank, Netherlands, 9648 BE
Novartis Investigative Site
Zutphen, Netherlands, 7207 AE
Novartis Investigative Site
Zwolle, Netherlands, 8011 JW
Norway
Novartis Investigative Site
Oslo, Norway, 0514
Novartis Investigative Site
Trondheim, Norway, 7006
Novartis Investigative Site
Tønsberg, Norway, 3116
Peru
Novartis Investigative Site
Trujillo, La Libertad, Peru
Novartis Investigative Site
Chiclayo, Lambayeque, Peru
Novartis Investigative Site
Bellavista, Lima, Peru, Callao 02
Novartis Investigative Site
Cercado de Lima, Lima, Peru, 01
Novartis Investigative Site
Jesus Maria, Lima, Peru, 11
Novartis Investigative Site
Miraflores, Lima, Peru, 18
Novartis Investigative Site
San Borja, Lima, Peru, 41
Novartis Investigative Site
San Isidro, Lima, Peru, 27
Novartis Investigative Site
San Juan de Miraflores, Lima, Peru, 29
Novartis Investigative Site
Lima, Peru, Lima 39
Poland
Novartis Investigative Site
Bytom, Poland, 41-902
Novartis Investigative Site
Chorzow, Poland, 41-506
Novartis Investigative Site
Gdansk, Poland, 80-180
Novartis Investigative Site
Gdynia, Poland, 81-423
Novartis Investigative Site
Gdynia, Poland, 81-519
Novartis Investigative Site
Gliwice, Poland, 44-100
Novartis Investigative Site
Grodzisk Mazowiecki, Poland, 05-825
Novartis Investigative Site
Katowice, Poland, 40-040
Novartis Investigative Site
Katowice, Poland, 40-084
Novartis Investigative Site
Klodzko, Poland, 57-300
Novartis Investigative Site
Krakow, Poland, 30-053
Novartis Investigative Site
Kraków, Poland, 31-501
Novartis Investigative Site
Lomza, Poland, 18-104
Novartis Investigative Site
Olawa, Poland, 55-200
Novartis Investigative Site
Opole, Poland, 45-706
Novartis Investigative Site
Ostrow Wielkopolski, Poland, 63-400
Novartis Investigative Site
Ostrowiec Swietokrzyski, Poland, 27-400
Novartis Investigative Site
Piotrkow Trybunalski, Poland, 97-300
Novartis Investigative Site
Plock, Poland, 09-402
Novartis Investigative Site
Poznan, Poland, 61-485
Novartis Investigative Site
Sandomierz, Poland, 27-600
Novartis Investigative Site
Tarnow, Poland, 33-100
Novartis Investigative Site
Torun, Poland, 87-100
Novartis Investigative Site
Warszawa, Poland, 03-242
Novartis Investigative Site
Warszawa, Poland, 04-628
Novartis Investigative Site
Wroclaw, Poland, 50-349
Novartis Investigative Site
Wroclaw, Poland, 50-420
Novartis Investigative Site
Wroclaw, Poland, 50-981
Novartis Investigative Site
Wroclaw, Poland, 52-612
Novartis Investigative Site
Zabrze, Poland, 41-800
Portugal
Novartis Investigative Site
Amadora, Portugal, 2720-276
Novartis Investigative Site
Aveiro, Portugal, 3814-501
Novartis Investigative Site
Carnaxide, Portugal, 2799-523
Novartis Investigative Site
Coimbra, Portugal, 3000-075
Novartis Investigative Site
Faro, Portugal, 8000-386
Novartis Investigative Site
Lisboa, Portugal, 1495-005
Novartis Investigative Site
Lisboa, Portugal, 1600-190
Novartis Investigative Site
Lisboa, Portugal, 1769-001
Novartis Investigative Site
Penafiel, Portugal, 4564-007
Novartis Investigative Site
Porto, Portugal, 4200-319
Puerto Rico
Novartis Investigative Site
Humacao, Puerto Rico, 00791
Novartis Investigative Site
Ponce, Puerto Rico, 00717
Novartis Investigative Site
San Juan, Puerto Rico, 00936-6528
Romania
Novartis Investigative Site
Bucharest, District 1, Romania, 012051
Novartis Investigative Site
Bucharest, District 1, Romania, 012064
Novartis Investigative Site
Bucharest, District 2, Romania, 021705
Novartis Investigative Site
Iasi, Jud Iasi, Romania, 700005
Novartis Investigative Site
Targu Mures, jud Mures, Romania, 540043
Novartis Investigative Site
Iasi, Jud. Iasi, Romania, 700506
Novartis Investigative Site
Targu Mures, Mures, Romania, 540136
Novartis Investigative Site
Baia Mare, Romania, 430123
Novartis Investigative Site
Brasov, Romania, 500281
Novartis Investigative Site
Brasov, Romania, 500427
Novartis Investigative Site
Cluj Napoca, Romania, 400006
Novartis Investigative Site
Cluj-Napoca, Romania, 400347
Novartis Investigative Site
Iasi, Romania, 700547
Novartis Investigative Site
Oradea, Romania, 410169
Novartis Investigative Site
Pitesti, Romania, 110114
Novartis Investigative Site
Targu Mures, Romania, 540096
Novartis Investigative Site
Timisoara, Romania, 300310
Novartis Investigative Site
Timisoara, Romania, 300736
Russian Federation
Novartis Investigative Site
Barnaul, Russian Federation, 656055
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454000
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454021
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454047
Novartis Investigative Site
Chelyabinsk, Russian Federation, 454048
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620028
Novartis Investigative Site
Ekaterinburg, Russian Federation, 620137
Novartis Investigative Site
Izhevsk, Russian Federation, 426009
Novartis Investigative Site
Kirov, Russian Federation, 610014
Novartis Investigative Site
Krasnodar, Russian Federation, 350063
Novartis Investigative Site
Kursk, Russian Federation, 305035
Novartis Investigative Site
Lubertsi, Russian Federation, 140006
Novartis Investigative Site
Moscow, Russian Federation, 105229
Novartis Investigative Site
Moscow, Russian Federation, 111020
Novartis Investigative Site
Moscow, Russian Federation, 111539
Novartis Investigative Site
Moscow, Russian Federation, 115432
Novartis Investigative Site
Moscow, Russian Federation, 117292
Novartis Investigative Site
Moscow, Russian Federation, 119992
Novartis Investigative Site
Moscow, Russian Federation, 121359
Novartis Investigative Site
Moscow, Russian Federation, 127473
Novartis Investigative Site
Moscow, Russian Federation, 129301
Novartis Investigative Site
Moscow, Russian Federation
Novartis Investigative Site
Nizhny Novgorod, Russian Federation, 603018
Novartis Investigative Site
Novosibirsk, Russian Federation, 630047
Novartis Investigative Site
Novosibirsk, Russian Federation, 630075
Novartis Investigative Site
Novosibirsk, Russian Federation, 630089
Novartis Investigative Site
Omsk, Russian Federation, 644018
Novartis Investigative Site
Perm, Russian Federation, 614097
Novartis Investigative Site
Pushkin,St-Petersburg, Russian Federation, 196601
Novartis Investigative Site
Ryazan, Russian Federation, 390026
Novartis Investigative Site
S.-Petersburg, Russian Federation, 196247
Novartis Investigative Site
Saint Petersburg, Russian Federation, 197022
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 194044
Novartis Investigative Site
Saint-Petersburg, Russian Federation, 197341
Novartis Investigative Site
Saratov, Russian Federation, 410012
Novartis Investigative Site
Saratov, Russian Federation, 410028
Novartis Investigative Site
St-Petersburg, Russian Federation, 191119
Novartis Investigative Site
St. Petersburg, Russian Federation, 198013
Novartis Investigative Site
Tyumen, Russian Federation, 625026
Novartis Investigative Site
Volgograd, Russian Federation, 400001
Novartis Investigative Site
Volgograd, Russian Federation, 400008
Novartis Investigative Site
Voronezh, Russian Federation, 394065
Novartis Investigative Site
Yaroslavl, Russian Federation, 150000
Novartis Investigative Site
Yaroslavl, Russian Federation, 150030
Novartis Investigative Site
Yaroslavl, Russian Federation, 150062
Slovakia
Novartis Investigative Site
Bratislava, Slovak Republic, Slovakia, 812 72
Novartis Investigative Site
Bratislava, Slovak Republic, Slovakia, 826 06
Novartis Investigative Site
Komarno, Slovak Republic, Slovakia, 94575
Novartis Investigative Site
Kosice, Slovak Republic, Slovakia, 040 01
Novartis Investigative Site
Kosice, Slovak republic, Slovakia, 04166
Novartis Investigative Site
Levice, Slovak Republic, Slovakia, 93401
Novartis Investigative Site
Nitra, Slovak Republic, Slovakia, 949 01
Novartis Investigative Site
Povazska Bystrica, Slovak republic, Slovakia, 01701
Novartis Investigative Site
Presov, Slovak republic, Slovakia, 08101
Novartis Investigative Site
Stropkov, Slovak republic, Slovakia, 09101
Novartis Investigative Site
Zilina, Slovak Republic, Slovakia, 010 01
Novartis Investigative Site
Zilina, Slovak Republic, Slovakia, 08001
Novartis Investigative Site
Bardejov, Slovakia, 085 01
Novartis Investigative Site
Bratislava, Slovakia, 81369
Novartis Investigative Site
Kosice, Slovakia, 040 01
Novartis Investigative Site
Kosice, Slovakia, 04001
Novartis Investigative Site
Lucenec, Slovakia, 98439
Novartis Investigative Site
Piestany, Slovakia, 921 01
Novartis Investigative Site
Presov, Slovakia, 080 01
Novartis Investigative Site
Trebisov, Slovakia, 075 01
Novartis Investigative Site
Trencin, Slovakia, 911 01
Novartis Investigative Site
Zilina, Slovakia, 012 07
South Africa
Novartis Investigative Site
Soweto, Gauteng, South Africa, 2013
Novartis Investigative Site
Benoni, South Africa
Novartis Investigative Site
Boksburg, South Africa
Novartis Investigative Site
Centurion, South Africa, 4001
Novartis Investigative Site
Johannesburg, South Africa, 2157
Novartis Investigative Site
Western Cape, South Africa, 7130
Novartis Investigative Site
Worcester, South Africa, 6850
Spain
Novartis Investigative Site
Sanlucar de Barrameda, Andalucia, Spain, 11540
Novartis Investigative Site
Sevilla, Andalucia, Spain, 41009
Novartis Investigative Site
Utrera, Andalucia, Spain, 41710
Novartis Investigative Site
Oviedo, Asturias, Spain, 33011
Novartis Investigative Site
Hospitalet de Llobregat, Barcelona, Spain, 08907
Novartis Investigative Site
Villamartin, Cadiz, Spain, 11650
Novartis Investigative Site
Badalona, Catalunya, Spain, 08916
Novartis Investigative Site
Barcelona, Catalunya, Spain, 08035
Novartis Investigative Site
Barcelona, Catalunya, Spain, 08036
Novartis Investigative Site
Tarragona, Catalunya, Spain, 43005
Novartis Investigative Site
Tortosa, Cataluña, Spain, 43500
Novartis Investigative Site
Alicante, Comunidad Valenciana, Spain, 03004
Novartis Investigative Site
Valencia, Comunidad Valenciana, Spain, 46014
Novartis Investigative Site
Santiago de Compostela, Galicia, Spain, 15706
Novartis Investigative Site
Majadahonda, Madrid, Spain, 28222
Novartis Investigative Site
Valdemoro, Madrid, Spain, 28342
Novartis Investigative Site
Barcelona, Spain, 08041
Novartis Investigative Site
Madrid, Spain, 28007
Novartis Investigative Site
Madrid, Spain, 28040
Novartis Investigative Site
Madrid, Spain, 28041
Novartis Investigative Site
Madrid, Spain, 28046
Novartis Investigative Site
Madrid, Spain, 28049
Sweden
Novartis Investigative Site
Falun, Sweden, 791 82
Novartis Investigative Site
Göteborg, Sweden, 416 85
Novartis Investigative Site
Karlstad, Sweden, 681 85
Novartis Investigative Site
Linkoping, Sweden, 581 85
Novartis Investigative Site
Lund, Sweden, SE-222 21
Novartis Investigative Site
Malmo, Sweden, SE 211 36
Novartis Investigative Site
Malmö, Sweden, 205 02
Novartis Investigative Site
Malmö, Sweden, 214 22
Novartis Investigative Site
Mölndal, Sweden, 431 80
Novartis Investigative Site
Nässjö, Sweden, SE 571 31
Novartis Investigative Site
Skelleftea, Sweden, 931 86
Novartis Investigative Site
Stockholm, Sweden, 111 57
Novartis Investigative Site
Stockholm, Sweden, 112 81
Novartis Investigative Site
Stockholm, Sweden, 17176
Novartis Investigative Site
Stockholm, Sweden, SE-111 35
Novartis Investigative Site
Sundsvall, Sweden, 851 86
Novartis Investigative Site
Sundsvall, Sweden, 852 31
Novartis Investigative Site
Umeå, Sweden, 901 85
Novartis Investigative Site
Uppsala, Sweden, SE-751 85
Novartis Investigative Site
Västerås, Sweden, s-721 89
Novartis Investigative Site
Örebro, Sweden, 701 85
Switzerland
Novartis Investigative Site
Basel, Switzerland, 4031
Novartis Investigative Site
Bellinzona, Switzerland, 6500
Novartis Investigative Site
Bern, Switzerland, 3010
Novartis Investigative Site
Biel, Switzerland, 2500
Novartis Investigative Site
Bruderholz, Switzerland, 4101
Novartis Investigative Site
Lugano, Switzerland, 6903
Novartis Investigative Site
Olten, Switzerland, 4600
Novartis Investigative Site
Winterthur, Switzerland, 8401
Novartis Investigative Site
Zuerich, Switzerland, 8091
Taiwan
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Yongkang, Tainan, Taiwan, 71004
Novartis Investigative Site
Tainan 704, Taiwan ROC, Taiwan, 70403
Novartis Investigative Site
Kaohsiung, Taiwan, 807
Novartis Investigative Site
Lin-Kou, Taiwan, 33305
Novartis Investigative Site
Niaosong Township, Taiwan, 83301
Novartis Investigative Site
Taichung, Taiwan, 40447
Novartis Investigative Site
Taipei, Taiwan, 10002
Novartis Investigative Site
Taipei, Taiwan, 104
Thailand
Novartis Investigative Site
Bangkok, Thailand, 10330
Novartis Investigative Site
Bangkok, Thailand, 10400
Novartis Investigative Site
Bangkok, Thailand, 10700
Novartis Investigative Site
Chiang Mai, Thailand, 50200
Turkey
Novartis Investigative Site
Ankara, Turkey, 06100
Novartis Investigative Site
Aydin, Turkey, 09100
Novartis Investigative Site
Balcova / Izmir, Turkey, 35340
Novartis Investigative Site
Etlik / Ankara, Turkey, 06018
Novartis Investigative Site
Fatih / Istanbul, Turkey, 34098
Novartis Investigative Site
Istanbul, Turkey, 34304
Novartis Investigative Site
Izmir, Turkey, 35040
Novartis Investigative Site
Kinikli / Denizli, Turkey, 20070
Novartis Investigative Site
Kocaeli, Turkey, 41380
Novartis Investigative Site
Sivas, Turkey, 58140
United Kingdom
Novartis Investigative Site
Leicester, Leicestershire, United Kingdom, LE3 9QP
Novartis Investigative Site
Dafen, Llanelli, United Kingdom, SA14 8QF
Novartis Investigative Site
Addlestone, Surrey, United Kingdom, KT15 2BH
Novartis Investigative Site
Chichester, West Sussex, United Kingdom, PO19 6SE
Novartis Investigative Site
Worthing, West Sussex, United Kingdom, BN11 2DH
Novartis Investigative Site
Cardiff, United Kingdom, CF5 4AD
Novartis Investigative Site
Chesterfield, United Kingdom, S44 5BL
Novartis Investigative Site
Colchester, United Kingdom, CO4 5JL
Novartis Investigative Site
East Yorkshire, United Kingdom, HU16 5JQ
Novartis Investigative Site
Glasgow, United Kingdom, G51 4TF
Novartis Investigative Site
Liverpool, United Kingdom, L14 3PE
Novartis Investigative Site
London, United Kingdom, SE1 7EH
Novartis Investigative Site
London, United Kingdom, SW17 0RE
Novartis Investigative Site
Manchester, United Kingdom, M23 9LT
Novartis Investigative Site
Southampton, United Kingdom, SO16 6YD
Novartis Investigative Site
Swindon, United Kingdom, SN3 6BB
Venezuela
Novartis Investigative Site
Caracas, Distrito Capital, Venezuela, 1010
Novartis Investigative Site
Caracas, Distrito Capital, Venezuela, 1040
Novartis Investigative Site
Caracas, Distrito Capital, Venezuela, 1060
Novartis Investigative Site
Valencia, Edo. Carabobo, Venezuela, 2001
Novartis Investigative Site
Barcelona, Estado Anzoátegui, Venezuela, 6001
Novartis Investigative Site
Puerto Ordaz, Estado Bolívar, Venezuela, 8050
Novartis Investigative Site
Caracas, Estado Miranda, Venezuela, 1061
Novartis Investigative Site
Cumana, Estado Sucre, Venezuela, 6101
Novartis Investigative Site
Maracaibo, Estado Zulia, Venezuela, 4011
Sponsors and Collaborators
Novartis Pharmaceuticals
Investigators
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Study Director: Novartis Pharmaceuticals Novartis Pharmaceuticals

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

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Responsible Party: Novartis Pharmaceuticals
ClinicalTrials.gov Identifier: NCT00853658     History of Changes
Other Study ID Numbers: CSPP100F2301
2008-004104-31 ( EudraCT Number )
First Posted: March 2, 2009    Key Record Dates
Results First Posted: November 25, 2016
Last Update Posted: November 25, 2016
Last Verified: October 2016
Keywords provided by Novartis ( Novartis Pharmaceuticals ):
Chronic Heart Failure
Cardiovascular death
CHF hospitalization
morbi-mortality trial
outcome study
endpoint driven
plasma renin activity
renin angiotensin aldosterone system
direct renin inhibitors
BNP
KCCQ
eGFR
(NYHA class II to IV) with elevated
BNP and reduced LVEF
Additional relevant MeSH terms:
Layout table for MeSH terms
Heart Failure
Heart Diseases
Cardiovascular Diseases
Enalapril
Enalaprilat
Angiotensin-Converting Enzyme Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antihypertensive Agents