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Somatostatin, Octreotide, Pentoxyfilline in the Prevention of Post-ERCP Pancreatitis and Molecular Markers

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ClinicalTrials.gov Identifier: NCT00222092
Recruitment Status : Completed
First Posted : September 22, 2005
Last Update Posted : August 24, 2011
Sponsor:
Information provided by:
University of Ioannina

Study Description
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Brief Summary:
Octreotide, somatostatin and pentoxyfilline commercially available drugs that are used in various clinical situations. They are safe and known for years. Octreotide and somatostatin have been used in many studies for the prophylaxis and treatment of pancreatitis and post-ERCP pancreatitis, while pentoxyfilline has shown effect on patients with alcoholic hepatitis, obstructive vasculitis etc. The aim of the study is to evaluate the efficacy of any of those treatments for the prophylaxis and treatment of post-ERCP pancreatitis. In addition some molecular markers of acute and chronic inflammation will be measured before and after the endoscopic procedures according to the study protocol.

Condition or disease
Post-ERCP Acute Pancreatitis

Study Design
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Study Type : Observational
Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Octreotide, Somatostatin, Pentoxyfilline or Placebo in the Prevention and the Course of Post-ERCP Pancreatitis and Study of Molecular Markers in Post-ERCP Pancreatitis
Study Start Date : September 2005
Study Completion Date : September 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pancreatitis

Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
patients undergoing endoscopic retrograde cholangiopancreatography
Criteria

Inclusion Criteria:

  • patients undergoing endoscopic retrograde cholangiopancreatography

Exclusion Criteria:

  • children, pregnant or breastfeeding women
  • patients with coagulation disorders
  • inability to access the papilla of Vater due to technical difficulties (previous surgery, malignant obstruction)
Contacts and Locations
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Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00222092


Locations
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Greece
Hepato-Gastroenterology Unit, Medical School of Ioannina - Greece
Ioannina, Greece, 45110
Sponsors and Collaborators
University of Ioannina
Investigators
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Principal Investigator: Dimitrios Sigounas, MD University of Ioannina
More Information
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ClinicalTrials.gov Identifier: NCT00222092    
Other Study ID Numbers: SIG-2005
First Posted: September 22, 2005    Key Record Dates
Last Update Posted: August 24, 2011
Last Verified: September 2005
Keywords provided by University of Ioannina:
post-ERCP pancreatitis
prophylaxis
prognosis
natural course
molecular markers
Additional relevant MeSH terms:
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Pancreatitis
Pancreatic Diseases
Digestive System Diseases