Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence (CACTIS)
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|ClinicalTrials.gov Identifier: NCT03845322|
Recruitment Status : Recruiting
First Posted : February 19, 2019
Last Update Posted : February 19, 2019
University of New Mexico
Information provided by (Responsible Party):
University of New Mexico
No Study Results Posted on ClinicalTrials.gov for this Study
|Recruitment Status :||Recruiting|
|Estimated Primary Completion Date :||September 28, 2020|
|Estimated Study Completion Date :||September 28, 2022|
Publications of Results:
Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E, Byers HR. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 1998 Jun;4(6):376-83.
Asher GN, Spelman K. Clinical utility of curcumin extract. Altern Ther Health Med. 2013 Mar-Apr;19(2):20-2. Review.
Bhandarkar SS, Arbiser JL. Curcumin as an inhibitor of angiogenesis. Adv Exp Med Biol. 2007;595:185-95. Review.
Brokinkel B, Ewelt C, Holling M, Hesselmann V, Heindel WL, Stummer W, Fischer BR. Routine postoperative CT-scans after burr hole trepanation for chronic subdural hematoma - better before or after drainage removal? Turk Neurosurg. 2013;23(4):458-63. doi: 10.5137/1019-5149.JTN.7269-12.0.
DiSilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
Fan X, Zhang C, Liu DB, Yan J, Liang HP. The clinical applications of curcumin: current state and the future. Curr Pharm Des. 2013;19(11):2011-31. Review.
Frati A, Salvati M, Mainiero F, Ippoliti F, Rocchi G, Raco A, Caroli E, Cantore G, Delfini R. Inflammation markers and risk factors for recurrence in 35 patients with a posttraumatic chronic subdural hematoma: a prospective study. J Neurosurg. 2004 Jan;100(1):24-32.
Gelabert-Gonzalez M, Aran-Echabe E. Can recurrence of chronic subdural hematoma be predicted? J Neurol Surg A Cent Eur Neurosurg. 2014 Sep;75(5):407. doi: 10.1055/s-0033-1358613. Epub 2013 Dec 19.
Ghosh S, Banerjee S, Sil PC. The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol. 2015 Sep;83:111-24. doi: 10.1016/j.fct.2015.05.022. Epub 2015 Jun 9. Review.
Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. Review.
Hennig R, Kloster R. Burr hole evacuation of chronic subdural haematomas followed by continuous inflow and outflow irrigation. Acta Neurochir (Wien). 1999;141(2):171-6.
Hickey MA, Zhu C, Medvedeva V, Lerner RP, Patassini S, Franich NR, Maiti P, Frautschy SA, Zeitlin S, Levine MS, Chesselet MF. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Mol Neurodegener. 2012 Apr 4;7:12. doi: 10.1186/1750-1326-7-12.
Hidaka H, Ishiko T, Furuhashi T, Kamohara H, Suzuki S, Miyazaki M, Ikeda O, Mita S, Setoguchi T, Ogawa M. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impact on human pancreatic carcinoma cell growth by autocrine regulation. Cancer. 2002 Sep 15;95(6):1206-14.
Hong HJ, Kim YJ, Yi HJ, Ko Y, Oh SJ, Kim JM. Role of angiogenic growth factors and inflammatory cytokine on recurrence of chronic subdural hematoma. Surg Neurol. 2009 Feb;71(2):161-5; discussion 165-6. doi: 10.1016/j.surneu.2008.01.023. Epub 2008 Apr 18.
King MD, McCracken DJ, Wade FM, Meiler SE, Alleyne CH Jr, Dhandapani KM. Attenuation of hematoma size and neurological injury with curcumin following intracerebral hemorrhage in mice. J Neurosurg. 2011 Jul;115(1):116-23. doi: 10.3171/2011.2.JNS10784. Epub 2011 Mar 18.
Lao CD, Ruffin MT 4th, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med. 2006 Mar 17;6:10.
Lin CC, Lu YM, Chen TH, Wang SP, Hsiao SH, Lin MS. Quantitative assessment of post-operative recurrence of chronic subdural haematoma using mean haematoma density. Brain Inj. 2014;28(8):1082-6. doi: 10.3109/02699052.2014.901559. Epub 2014 Apr 4.