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Reminders Through Association & Prescription Adherence

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ClinicalTrials.gov Identifier: NCT03697083
Recruitment Status : Terminated (The primary hypotheses were unsupported with half of the data collected.)
First Posted : October 5, 2018
Results First Posted : August 6, 2019
Last Update Posted : August 6, 2019
Sponsor:
Information provided by (Responsible Party):
University of Pennsylvania

Study Type Interventional
Study Design Allocation: Randomized;   Intervention Model: Parallel Assignment;   Masking: None (Open Label);   Primary Purpose: Health Services Research
Condition Medication Adherence
Interventions Other: Reminders Through Association
Other: Active Control
Other: Baseline Control
Enrollment 777
Recruitment Details  
Pre-assignment Details  
Arm/Group Title Reminders Through Association Arm Active Control Arm Baseline Control Arm
Hide Arm/Group Description

participants will be prompted to think of a reminder cue that will help them remember to pick up the prescription.

Reminders Through Association: Participants receive 8 text messages asking them to think of a reminder cue that will help them remember to pick up the prescription and use the cue.

Participants will be asked to think about where they will store their prescription.

Active Control: Participants receive 8 text messages asking them to think of where they plan to store their medication once they pick it up and to think about that location on their intended date of pickup.

Participants are thanked for enrolling in the reminder program.

Baseline Control: Participants receive 1 text message thanking participants for enrolling in the reminder program. Participants are not contacted further.

Period Title: Overall Study
Started 262 260 255
Completed 262 250 255
Not Completed 0 10 0
Arm/Group Title Reminders Through Association Arm Active Control Arm Baseline Control Arm Total
Hide Arm/Group Description

participants will be prompted to think of a reminder cue that will help them remember to pick up the prescription.

Reminders Through Association: Participants receive 8 text messages asking them to think of a reminder cue that will help them remember to pick up the prescription and use the cue.

Participants will be asked to think about where they will store their prescription.

Active Control: Participants receive 8 text messages asking them to think of where they plan to store their medication once they pick it up and to think about that location on their intended date of pickup.

Participants are thanked for enrolling in the reminder program.

Baseline Control: Participants receive 1 text message thanking participants for enrolling in the reminder program. Participants are not contacted further.

Total of all reporting groups
Overall Number of Baseline Participants 262 260 255 777
Hide Baseline Analysis Population Description
[Not Specified]
Age, Continuous  
Mean (Standard Deviation)
Unit of measure:  Years
Number Analyzed 262 participants 260 participants 255 participants 777 participants
41.3  (13.6) 41.2  (13.8) 40.44  (13.4) 41  (13.58)
Sex/Gender, Customized  
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 262 participants 260 participants 255 participants 777 participants
Male
39
  14.9%
35
  13.5%
45
  17.6%
119
  15.3%
Female
218
  83.2%
218
  83.8%
205
  80.4%
641
  82.5%
Other
4
   1.5%
6
   2.3%
4
   1.6%
14
   1.8%
Prefer not to specify
1
   0.4%
1
   0.4%
1
   0.4%
3
   0.4%
Race and Ethnicity Not Collected   [1] 
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 0 participants 0 participants 0 participants 0 participants
0
[1]
Measure Analysis Population Description: Race and Ethnicity were not collected from any participant.
1.Primary Outcome
Title Picking up Prescription on Intended Date of Pickup
Hide Description

At the beginning of the study, participants indicate the date they plan to pick up their prescription. Participants are later asked to text a picture of their prescription receipt to the experimenter after they complete the prescription reminder program. The receipt must satisfy three criteria:

  1. The receipt must show that a prescription was purchased.
  2. The receipt must show the date of purchase. This date of purchase must match the participant’s intended pick up date.
  3. The participant must write the word “End” on their receipt. Upon receiving the picture text, one research assistant will verify that the image of the receipt satisfies all three criteria.

the investigators' primary dependent variable is binary taking the value one if the participant sends a picture of their receipt to the investigators that satisfies all criteria stated above and taking the value zero if otherwise.

Time Frame The time frame can range from less than 1 day to a maximum of 7 days.
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Reminders Through Association Arm Active Control Arm Baseline Control Arm
Hide Arm/Group Description:

participants will be prompted to think of a reminder cue that will help them remember to pick up the prescription.

Reminders Through Association: Participants receive 8 text messages asking them to think of a reminder cue that will help them remember to pick up the prescription and use the cue.

Participants will be asked to think about where they will store their prescription.

Active Control: Participants receive 8 text messages asking them to think of where they plan to store their medication once they pick it up and to think about that location on their intended date of pickup.

Participants are thanked for enrolling in the reminder program.

Baseline Control: Participants receive 1 text message thanking participants for enrolling in the reminder program. Participants are not contacted further.

Overall Number of Participants Analyzed 262 260 255
Mean (Standard Deviation)
Unit of Measure: percentage of prescriptions pickuped
46  (.50) 46  (.50) 15  (.36)
Time Frame Adverse event data was collected during data collection and one week after recruitment ended.
Adverse Event Reporting Description This intervention was solely to help people pick up their prescriptions. Participants only received a series of text messages so there was not risk serious adverse events.
 
Arm/Group Title Reminders Through Association Arm Active Control Arm Baseline Control Arm
Hide Arm/Group Description

participants will be prompted to think of a reminder cue that will help them remember to pick up the prescription.

Reminders Through Association: Participants receive 8 text messages asking them to think of a reminder cue that will help them remember to pick up the prescription and use the cue.

Participants will be asked to think about where they will store their prescription.

Active Control: Participants receive 8 text messages asking them to think of where they plan to store their medication once they pick it up and to think about that location on their intended date of pickup.

Participants are thanked for enrolling in the reminder program.

Baseline Control: Participants receive 1 text message thanking participants for enrolling in the reminder program. Participants are not contacted further.

All-Cause Mortality
Reminders Through Association Arm Active Control Arm Baseline Control Arm
Affected / at Risk (%) Affected / at Risk (%) Affected / at Risk (%)
Total   0/262 (0.00%)   0/260 (0.00%)   0/255 (0.00%) 
Show Serious Adverse Events Hide Serious Adverse Events
Reminders Through Association Arm Active Control Arm Baseline Control Arm
Affected / at Risk (%) Affected / at Risk (%) Affected / at Risk (%)
Total   0/262 (0.00%)   0/260 (0.00%)   0/255 (0.00%) 
Show Other (Not Including Serious) Adverse Events Hide Other (Not Including Serious) Adverse Events
Frequency Threshold for Reporting Other Adverse Events 0%
Reminders Through Association Arm Active Control Arm Baseline Control Arm
Affected / at Risk (%) Affected / at Risk (%) Affected / at Risk (%)
Total   0/262 (0.00%)   0/260 (0.00%)   0/255 (0.00%) 
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
Layout table for Results Point of Contact information
Name/Title: Katherine K. Milkman Ph.D.
Organization: University of Pennsylvania
Phone: 215-573-9646
EMail: kmilkman@wharton.upenn.edu
Layout table for additonal information
Responsible Party: University of Pennsylvania
ClinicalTrials.gov Identifier: NCT03697083     History of Changes
Other Study ID Numbers: 825556
First Submitted: August 28, 2018
First Posted: October 5, 2018
Results First Submitted: February 25, 2019
Results First Posted: August 6, 2019
Last Update Posted: August 6, 2019