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Clinical Effects of Exercise Program Added to Pulmonary Rehabilitation in Patients With Cystic Fibrosis

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ClinicalTrials.gov Identifier: NCT03295201
Recruitment Status : Completed
First Posted : September 27, 2017
Results First Posted : October 26, 2018
Last Update Posted : October 26, 2018
Sponsor:
Information provided by (Responsible Party):
Marmara University

Study Type Interventional
Study Design Allocation: Randomized;   Intervention Model: Parallel Assignment;   Masking: Triple (Participant, Care Provider, Outcomes Assessor);   Primary Purpose: Treatment
Condition Cystic Fibrosis
Interventions Other: Active cycle of breathing techniques (ACBT)
Other: Postural Exercise
Enrollment 22
Recruitment Details Recruitment period was March 2017-October 2017 Setting: A university hospital outpatient clinics
Pre-assignment Details Number of patients assessed for eligibility was 30. Among them,8 participants were excluded due to being inappropiate for the inclusion criteria (6 were out of age limits, 2 did not agree to participate in the study)
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Period Title: Overall Study
Started 11 11
Completed 10 9
Not Completed 1 2
Reason Not Completed
Lost to Follow-up             1             1
Hospital admission             0             1
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group Total
Hide Arm/Group Description

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Total of all reporting groups
Overall Number of Baseline Participants 10 9 19
Hide Baseline Analysis Population Description
[Not Specified]
Age, Continuous  
Mean (Standard Deviation)
Unit of measure:  Years
Number Analyzed 10 participants 9 participants 19 participants
9  (2) 10  (3) 9  (2)
Sex: Female, Male  
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 10 participants 9 participants 19 participants
Female
3
  30.0%
4
  44.4%
7
  36.8%
Male
7
  70.0%
5
  55.6%
12
  63.2%
Race and Ethnicity Not Collected   [1] 
Measure Type: Count of Participants
Unit of measure:  Participants
Number Analyzed 0 participants 0 participants 0 participants
0
[1]
Measure Analysis Population Description: Race and Ethnicity were not collected from any participant.
Region of Enrollment  
Measure Type: Number
Unit of measure:  Participants
Turkey Number Analyzed 10 participants 9 participants 19 participants
10 9 19
Body Mass Index  
Mean (Standard Deviation)
Unit of measure:  Kg/m^2
Number Analyzed 10 participants 9 participants 19 participants
16  (2) 16  (2) 16  (2)
1.Primary Outcome
Title Exercise Tolerance
Hide Description Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: meters
817  (234.62) 792.22  (327.21)
2.Primary Outcome
Title Exercise Tolerance
Hide Description Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.
Time Frame 6 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: meters
980  (277.24) 1058.77  (594.67)
3.Primary Outcome
Title Exercise Tolerance
Hide Description Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.
Time Frame 3 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: meters
1104  (306.73) 1036.66  (457.16)
4.Primary Outcome
Title Exercise Tolerance
Hide Description Modified Shuttle Test (MST) is used to measure the exercise tolerance. The patient is asked to walk until feeling tired between two fixed objects with a 10-meter interval, starting at normal walking speed and increasing the speed at the beginning of each minute. Maximum distance (meters) is measured for the test.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: meters
1251  (324.15) 1161.11  (594.06)
5.Secondary Outcome
Title Quality of Life
Hide Description The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: units on a scale
86.4  (5.75) 92.77  (9.94)
6.Secondary Outcome
Title Quality of Life
Hide Description The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.
Time Frame 6 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: units on a scale
88.9  (7.04) 90.88  (13.37)
7.Secondary Outcome
Title Quality of Life
Hide Description The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.
Time Frame 3 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: units on a scale
87.2  (5.57) 93.33  (11.35)
8.Secondary Outcome
Title Quality of Life
Hide Description The Cystic Fibrosis Questionnaire-Revised (CFQR) is used to measure the quality of life. This scale is found to be valid and reliable in Turkish. The child version of this test consists 35 questions about physical function, emotional function, social function, body appearance, eating disorders, treatment difficulties, respiratory and digestive symptoms. The total score is calculated between 0-100 and higher scores define the better condition.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: units on a scale
89.7  (7.84) 95.55  (12.64)
9.Secondary Outcome
Title Postural Stability
Hide Description The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: seconds
1.29  (0.85) 1.03  (0.53)
10.Secondary Outcome
Title Postural Stability
Hide Description The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.
Time Frame 6 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: seconds
0.91  (0.66) 0.83  (0.65)
11.Secondary Outcome
Title Postural Stability
Hide Description The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.
Time Frame 3 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: seconds
0.88  (0.72) 0.65  (0.52)
12.Secondary Outcome
Title Postural Stability
Hide Description The Balance Master Device- Limits of Stability Test (LOS) is used for to measure the postural stability of children. The LOS consists a 18x60 inch of a pressure platform which connected to a computer system. The patient is asked to stand on the platform barefoot and watch the image which can be moved by trunk movement on the computer the monitor. It is required to move the image towards to target points on the monitor with commands. Reaction time, movement velocity, endpoint excursion, maximum excursion and direction control parameters are calculated during these trunk movements. Reaction time (seconds) parameter is preferred to use for this study.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Error)
Unit of Measure: seconds
1.15  (0.69) 0.92  (0.46)
13.Secondary Outcome
Title Pulmonary Function
Hide Description Forced expiratory volume in 1 second (FEV1)
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: millilitres
82.8  (14.57) 83.78  (21.06)
14.Secondary Outcome
Title Pulmonary Function
Hide Description Forced expiratory volume in 1 second (FEV1)
Time Frame 6 weeks
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: millilitres
93.3  (21.71) 82.11  (17.14)
15.Secondary Outcome
Title Pulmonary Function
Hide Description Forced expiratory volume in 1 second (FEV1)
Time Frame 3 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: millilitres
86.6  (12.19) 82.77  (17.85)
16.Secondary Outcome
Title Pulmonary Function
Hide Description Forced expiratory volume in 1 second (FEV1)
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: millilitres
87.7  (16.95) 90  (23.52)
17.Secondary Outcome
Title Spinal Deformity- The Cobb Angle (Researcher 1)
Hide Description The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
2.37  (1.40) 7.75  (5.95)
18.Secondary Outcome
Title Spinal Deformity- The Cobb Angle (Researcher 2)
Hide Description The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
2.12  (2.1) 7.75  (5.12)
19.Secondary Outcome
Title Spinal Deformity- The Cobb Angle (Researcher 1)
Hide Description The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
3.5  (2.56) 5.25  (3.41)
20.Secondary Outcome
Title Spinal Deformity- The Cobb Angle (Researcher 2)
Hide Description The Cobb angle was measured on anteroposterior scoliosis graphs by the angle between the superior end plate of the vertebra corpus where the curve begins and the end plate of the vertebra corpus which the curve ends.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
3.88  (2.42) 5.5  (2.83)
21.Secondary Outcome
Title Spinal Deformity- The Modified Cobb Angle (Researcher 1)
Hide Description The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
35.33  (12.62) 34.33  (6.84)
22.Secondary Outcome
Title Spinal Deformity- The Modified Cobb Angle (Researcher 2)
Hide Description The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.
Time Frame Before treatment
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
34.67  (11.76) 33.11  (7.4)
23.Secondary Outcome
Title Spinal Deformity- The Modified Cobb Angle (Researcher 1)
Hide Description The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
35.5  (8.09) 32.33  (3.08)
24.Secondary Outcome
Title Spinal Deformity- The Modified Cobb Angle (Researcher 2)
Hide Description The Modified Cobb angle was found on lateral scoliosis graphs by the angle between the superior end plate of the T4 vertebra corpus and the inferior end plate of the T12 vertebra corpus.
Time Frame 6 months
Hide Outcome Measure Data
Hide Analysis Population Description
[Not Specified]
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description:

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Overall Number of Participants Analyzed 10 9
Mean (Standard Deviation)
Unit of Measure: degrees
35  (7.87) 32.4  (3.33)
Time Frame 6 months
Adverse Event Reporting Description All-Cause Mortality, Serious, or Other (non-serious) Adverse Events were monitored.
 
Arm/Group Title Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Hide Arm/Group Description

Active cycle of breathing techniques (ACBT) and postural exercise program

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

Postural Exercise: Postural exercise program will include thoracic vertebra mobilization, pectoral stretching, scapula and thoracic extensors strengthening and core stability exercises. Postural exercise program will apply 1 per a week for 6 weeks.

Active cycle of breathing techniques (ACBT)

Active cycle of breathing techniques (ACBT): ACBT involves three phases (Breathing control, chest expansion exercise, and huff coughing). These phases will apply with a sequence to remove secretion. ACBT will apply 1 per a week for 6 weeks.

All-Cause Mortality
Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Affected / at Risk (%) Affected / at Risk (%)
Total   0/10 (0.00%)   0/9 (0.00%) 
Show Serious Adverse Events Hide Serious Adverse Events
Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Affected / at Risk (%) Affected / at Risk (%)
Total   0/10 (0.00%)   0/9 (0.00%) 
Show Other (Not Including Serious) Adverse Events Hide Other (Not Including Serious) Adverse Events
Frequency Threshold for Reporting Other Adverse Events 0%
Pulmonary Rehabilitation+Exercise Group Pulmonary Rehabilitation Group
Affected / at Risk (%) Affected / at Risk (%)
Total   0/10 (0.00%)   0/9 (0.00%) 
Certain Agreements
Principal Investigators are NOT employed by the organization sponsoring the study.
There is NOT an agreement between Principal Investigators and the Sponsor (or its agents) that restricts the PI's rights to discuss or publish trial results after the trial is completed.
Results Point of Contact
Name/Title: Dr. Kardelen Gencer Atalay
Organization: Marmara University
Phone: 5324404887 ext 532
Responsible Party: Marmara University
ClinicalTrials.gov Identifier: NCT03295201     History of Changes
Other Study ID Numbers: 09.2015.287
First Submitted: August 23, 2017
First Posted: September 27, 2017
Results First Submitted: October 24, 2017
Results First Posted: October 26, 2018
Last Update Posted: October 26, 2018