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Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

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ClinicalTrials.gov Identifier: NCT04439565
Recruitment Status : Recruiting
First Posted : June 19, 2020
Last Update Posted : June 19, 2020
Sponsor:
Information provided by (Responsible Party):
Zaiping Jing, Chinese Medical Association

Tracking Information
First Submitted Date June 17, 2020
First Posted Date June 19, 2020
Last Update Posted Date June 19, 2020
Estimated Study Start Date June 17, 2020
Estimated Primary Completion Date June 17, 2023   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: June 17, 2020)
gege [ Time Frame: 2023 ]
Discovery of known or unknown genes
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Official Title Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
Brief Summary Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Detailed Description Not Provided
Study Type Observational
Study Design Observational Model: Family-Based
Time Perspective: Other
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples With DNA
Description:
DNA is extracted from blood and preserved for a long time.
Sampling Method Non-Probability Sample
Study Population 1, family members have no traumatic aortic dissection; 2, no pregnancy or tumor.
Condition
  • Aortic Dissection
  • Family Research
  • Aortic Dissection, Familial, With or Without Aortic Aneurysm
Intervention Genetic: movement
aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.
Study Groups/Cohorts Not Provided
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Recruiting
Estimated Enrollment
 (submitted: June 17, 2020)
100
Original Estimated Enrollment Same as current
Estimated Study Completion Date July 17, 2023
Estimated Primary Completion Date June 17, 2023   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;

Exclusion Criteria:

  • Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms
Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers Yes
Contacts
Contact: Jing Zaiping, professor 02131161670 xueguanky@163.com
Listed Location Countries China
Removed Location Countries  
 
Administrative Information
NCT Number NCT04439565
Other Study ID Numbers https://orcid.org/0000-0002-05
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement
Plan to Share IPD: Undecided
Responsible Party Zaiping Jing, Chinese Medical Association
Study Sponsor Chinese Medical Association
Collaborators Not Provided
Investigators Not Provided
PRS Account Chinese Medical Association
Verification Date June 2020