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Mental Imagery Neurofeedback in Strokerehabilitation

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ClinicalTrials.gov Identifier: NCT03994042
Recruitment Status : Completed
First Posted : June 21, 2019
Last Update Posted : June 30, 2020
Sponsor:
Collaborators:
Danderyd Hospital
Vinnova
Information provided by (Responsible Party):
Mälardalen University

Tracking Information
First Submitted Date  ICMJE April 15, 2019
First Posted Date  ICMJE June 21, 2019
Last Update Posted Date June 30, 2020
Actual Study Start Date  ICMJE August 5, 2019
Actual Primary Completion Date January 17, 2020   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: June 19, 2019)
  • Change of Fugl-Meyer Upper Extremity scale score (0-66 points) [ Time Frame: Up to 10 weeks ]
    Arm and hand function
  • Change of EEG alpha and beta activity [ Time Frame: Up to 7 weeks ]
    Brain motor network activity reflected in neurofeedback signal
  • Change of fMRI BOLD activity [ Time Frame: Up to 7 weeks ]
    Brain motor network activity
Original Primary Outcome Measures  ICMJE Same as current
Change History
Current Secondary Outcome Measures  ICMJE
 (submitted: June 19, 2019)
  • Change of monofilament test score [ Time Frame: Up to 10 weeks ]
    Two point discrimination and monofilament test for sensory function
  • Change of box and block test score (0-150) [ Time Frame: Up to 10 weeks ]
    Gross manual dexterity
  • Change of JAMAR® digital Hand Dynamometer scores (0-90) [ Time Frame: Up to 10 weeks ]
    Grip strength
  • Change of visuomotor force-tracking task scores [ Time Frame: Up to 10 weeks ]
    Quantification of timing and precision aspects of force grip modulation
  • Change of stroke Impact Scale 16 scores (15-80 points) [ Time Frame: Up to 10 weeks ]
    Activity limitations related to physical function
Original Secondary Outcome Measures  ICMJE Same as current
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Mental Imagery Neurofeedback in Strokerehabilitation
Official Title  ICMJE EEG-based Mental Imagery Feedback in Stroke Patients With Severe Hand Dysfunction
Brief Summary This research project will investigate neurofeedback training in stroke rehabilitation during which patients receive feedback in real time from their brain activity measured with ElectroEncephaloGraphy (EEG). The investigators hypothesize that the feedback training allows to internally stimulate brain motor networks in order to promote functional recovery of the hand.
Detailed Description

This study will be carried out as a pilot study in order to optimize and set parameters for a subsequent study that will involve more stroke patients. Stroke patients will be trained to mentally imagine the opening and closing of the hand (hereafter named MI, Motor Imagery). During the training, the patients will receive visual feedback in real time that reflects the neural activity related to motor processes. The NeuroFeedback (NF) will be projected with minimal time delay to maximize the neural learning. This type of brain training with feedback is thought to have significant importance to stimulate the ability of the brain to reorganize and compensate for a damaged region.

Each participant will go through the following data collection procedure (total of 27-28 measurement sessions per RP):

  • Clinical baseline evaluations, 1 time/week during 3 weeks
  • 1 MRI measurement during one week
  • 2-3 calibration EEG recordings during one week
  • MI-neurofeedback training [3 times/week] + Clinical intervention evaluation [1 time/week] during 4 weeks
  • 1 MRI measurement + 1 calibration EEG recording during one week
  • Clinical intervention evaluations, 1 time/week during 3 weeks

Magnetic Resonance Imaging (MRI) measurements. The MRI exam will be carried out on a Siemens MAGNETOM Prisma 3T scanner (head-coil with 20 channels) at baseline and at final assessment session at Stockholm University Brain Imaging Centre. The MRI protocol comprises i) anatomical whole brain spin-echo T1 and T2 weighted sequences for description of lesion size and location ii) acquisition of T2*-weighted gradient echo EPI-BOLD images of the whole brain for assessment of resting state functional connectivity of sensorimotor networks (resting-state functional MRI (fMRI)), and iii) the same sequence as the previous with rest interleaved by a motor imagery paradigm further described below.

Motor Imagery (MI) paradigm. The paradigm consists of instructing RP, by the use of a mirrored computer screen, to either i) rest his/her mind with eyes open, ii) mentally imagine a hand movement (MI), or ii) execute a hand movement. The hand movements that are instructed are either to close the hand or to open the hand and extend the fingers. RP will perform several repetitions of each hand movement (MI and execution) in order to collect a statistical basis.

Calibration EEG recording. Calibration of EEG recordings will be performed at 2-3 times during 1 week prior to the intervention and one time after the intervention while the participant performs the mental imagery paradigm described above. RP will be seated in front a computer screen and ratings will be registered by the use of a button-press. During these session, EEG, EOG, EMG, and accelerometer-data will be collected and are further described below.

ElectroEncephaloGram (EEG), ElectroOculoGram (EOG), ElectroMyoGram (EMG) and accelerometer equipment. The EEG equipment consists of a 64-electrode scalp EEG acquisition system (Brain Products ActiCHamp). The 64 electrodes (active Ag/AgCl) will be distributed according to the extended 10-20 reference placement system. In addition to the EEG recording, 3 electrodes (passive Ag/AgCl, Brain Products) will be placed on each side of both eyes and on the earlob to measure eye-movements during the experiment (EOG). EMG electrodes (passive Ag/AgCl, Brain Products) will be placed over four muscles controlling the wrist and fingers according to a standardized protocol. Two accelerometer-sensors (Brain Products) will be placed on the hand and the index finger in order to record movement-related activity.

EEG, EOG, EMG and accelerometer data analysis. The recorded data will be further analyzed offline in order to evaluate the characteristic features in the data that best describe MI of hand movements. This will be performed in Matlab and Labview combining custom-made scripts with already developed toolboxes (such as EEGLab, Chronux). Features to be evaluated will include the evoked activity, the time-frequency spectra, phase, correlation coefficients, coherency among other. When the feature that best describes MI has been identified different classifier and pattern recognition methods will be evaluated in extracting the information. Intelligent algorithms, Support Vector Machine (SVM), regularized linear regression, naïve Bayes classifiers among others will be evaluated and compared. These are commonly used methods in the field of neurotechnology and a prior comparison-study using neural data from invasive recordings shows the importance of choosing a well-adapted classifier for extracting information.

MI-NeuroFeedback Training (NFT). EEG, EOG, EMG and accelerometer-data will be collected as described in the section "EEG, EMG and accelerometer equipment". RP will perform the MI paradigm without the execution of hand movements. Real-time feedback from recorded EEG-activity will be provided to RP during MI. The feedback consists of a virtual hand on a computer screen whose movements reflect the brain activity of RP related to MI. The recorded data will be further analyzed offline with the analytic tools that are described in previous section.

Study Type  ICMJE Interventional
Study Phase  ICMJE Not Applicable
Study Design  ICMJE Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Condition  ICMJE
  • Stroke
  • Hemiparesis
Intervention  ICMJE Device: Mental imagery neurofeedback training
Mental Imagery (MI)-neurofeedback training, 2-3 hours, 3 times/week for 4 weeks.
Study Arms  ICMJE Experimental: Mental imagery neurofeedback training
Complete intervention with mental imagery neurofeedback training. Patients recruited by physioterapists who underwent baseline evaluations with clinical tests, fMRI and EEG measurements. Patients will after intervention perform clinical tests, fMRI, and EEG measurements to evaluate outcomes of intervention.
Intervention: Device: Mental imagery neurofeedback training
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: November 15, 2019)
2
Original Estimated Enrollment  ICMJE
 (submitted: June 19, 2019)
4
Actual Study Completion Date  ICMJE January 17, 2020
Actual Primary Completion Date January 17, 2020   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • More than 6 months since first time stroke onset and with remaining hemiparesis in upper extremity;
  • able to participate fully in the intervention including screening of cognitive function with the Cambridge Neuropsychological Test Automated Battery;
  • able to perform Functional Magnetic Resonance Imaging (fMRI);
  • able to passively extend the wrist 15 degrees and extend fingers fully with a neutral position of the wrist.

Subgroup 1 (n=2):

  • be able to voluntarily control the power of their grip when requested according to the Visuomotor force tracking method and/or according to the clinical assessment of a therapist (while holding the patient´s hand).
  • Fugl-Meyer Upper Extremity (UE) scale (Fugl-Meyer 1975): <14 points on the hand subscale (C) in addition to < 48 points on the total score (equivalent to moderate disability in the upper extremity

Subgroup 2 (n=2):

- no detected voluntary grip or release function

Exclusion Criteria:

  • Other neurological or musculoskeletal disease/injury, contagious disease or treatment with botulinum toxin in the upper extremity during the past 3 months.
  • current or history of epilepsy, hearing problems, metal implants in the brain/skull cochlear implants, any implanted neurostimulator, cardiac pacemaker or cardiac implants of metal, infusion device.
  • other neurological disorder, pregnancy, current or history of severe psychiatric disorder with need for pharmacological treatment
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE Sweden
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT03994042
Other Study ID Numbers  ICMJE 2019-01577
Has Data Monitoring Committee No
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement  ICMJE
Plan to Share IPD: No
Responsible Party Mälardalen University
Study Sponsor  ICMJE Mälardalen University
Collaborators  ICMJE
  • Danderyd Hospital
  • Vinnova
Investigators  ICMJE
Principal Investigator: Elaine Astrand Mälardalen University
PRS Account Mälardalen University
Verification Date June 2020

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP