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Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER) (MINER)

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ClinicalTrials.gov Identifier: NCT03665740
Recruitment Status : Recruiting
First Posted : September 11, 2018
Last Update Posted : September 11, 2018
Sponsor:
Collaborators:
Texas A&M University
Baylor University
KR Love Quantitative Consulting and Collaboration
Information provided by (Responsible Party):
Dena Davidson, VISN 17 Center of Excellence

Tracking Information
First Submitted Date  ICMJE August 8, 2018
First Posted Date  ICMJE September 11, 2018
Last Update Posted Date September 11, 2018
Actual Study Start Date  ICMJE August 1, 2018
Estimated Primary Completion Date August 31, 2022   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: September 7, 2018)
  • Change from baseline in Cognitive Function [ Time Frame: Baseline & Post (week 26) ]
    CVLT-II: measure of cognitive functioning and memory
  • Change from baseline in Mood [ Time Frame: Baseline, Mid (week 13) and Post (week 26) ]
    Beck Depression Inventory II
  • Change from baseline in Daily Functioning [ Time Frame: Baseline and Post (week 26) ]
    WHODAS 2.0: measure of disability and global health
Original Primary Outcome Measures  ICMJE Same as current
Change History No Changes Posted
Current Secondary Outcome Measures  ICMJE
 (submitted: September 7, 2018)
  • Change from baseline in Structural MRI Scans [ Time Frame: Baseline & Post (Week 26) ]
    Structural MRI scanning of hippocampus
  • Change from baseline in Diffusion Tensor Imaging [ Time Frame: Baseline & Post (Week 26) ]
    A diffusion tensor imaging scan of hippocampus
Original Secondary Outcome Measures  ICMJE Same as current
Current Other Pre-specified Outcome Measures
 (submitted: September 7, 2018)
Change from baseline in Pro-inflammatory cytokines [ Time Frame: Baseline & Post (Week 26) ]
IL-1β; TNF-α; IL-6; IL-1α; Interferon-Y; G-CSF/CSF3; GM_CSF/CSF2; IL-8; IP-10; RANTES; Resistin; PAI-1; IL-12; IL-13; Eotaxin-3; MCP-1; MIP-1α; IL-2; Leptin; Adiponectin; IL-17α; IL-4; IL10
Original Other Pre-specified Outcome Measures Same as current
 
Descriptive Information
Brief Title  ICMJE Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER)
Official Title  ICMJE A Pilot RCT on the Effect of Resveratrol on Mood, Memory Deficits, Hippocampal Inflammation and Neurogenesis in Veterans With Gulf War Illness
Brief Summary Since their return from military service in the 1990-1991 Gulf War, many Veterans have been affected by debilitating symptoms that are not easily explained. A leading hypothesis states that the combination of exposure to toxic chemicals and environmental stressors are responsible for a cluster of debilitating symptoms known as Gulf War Illness (GWI). Research has found that over-the-counter antioxidant supplements such as resveratrol may reverse the damage that causes these debilitating symptoms. Resveratrol is a nutrient found abundantly in the skin of red grapes that is known to have robust antioxidant and anti-inflammatory properties. The investigators predict that resveratrol treatment will improve memory issues, difficulties with thinking and mood problems in Veterans with GWI and that resveratrol will do so with minimal risk.
Detailed Description

A randomized controlled trial is proposed that will employ well-validated instruments and state-of-the-art techniques to assess improvements in cognitive functioning, functional status, mood, hippocampal neurogenesis and functional connectivity as well as anti-inflammatory and antioxidant effects of treatment with resveratrol. Design: The proposed study will be an intent-to-treat outpatient, randomized, double-blind, clinical trial of 93 Veterans who meet the Centers for Disease Control and Prevention and Kansas case definitions for GWI.

The study involves a comparison of resveratrol at a dose of 2000 mg and placebo. All doses will be administered orally once or twice daily. Doses of resveratrol at 500 mg will begin with a dose titration period. In order to reach a maximum dose of 2000 mg for the resveratrol, titration will begin at 500 mg for 6 weeks, then increased to 1000 mg for 6 weeks and increased to 1500 mg for 6 weeks and increased to 2000 mg for the remaining 6 weeks on treatment. Morning dosing will be taken with or before breakfast. Evening dosing will be taken with or before dinner.

Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 2
Study Design  ICMJE Allocation: Randomized
Intervention Model: Parallel Assignment
Intervention Model Description:
Randomized Double-blind Placebo controlled, intent-to-treat
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Masking Description:
double blind
Primary Purpose: Treatment
Condition  ICMJE Gulf War Illness
Intervention  ICMJE Drug: Resveratrol
resveratrol is an OTC supplement
Study Arms  ICMJE
  • Experimental: Resveratrol
    Doses of resveratrol at 500 mg will begin with a dose titration period. In order to reach a maximum dose of 2000 mg for the resveratrol, titration will begin at 500 mg for 6 weeks, then increased to 1000 mg for 6 weeks and increased to 1500 mg for 6 weeks and increased to 2000 mg for the remaining 6 weeks on treatment.
    Intervention: Drug: Resveratrol
  • Placebo Comparator: Placebo
    Doses of placebo at 500 mg will begin with a dose titration period. In order to reach a maximum dose of 2000 mg for the placebo, titration will begin at 500 mg for 6 weeks, then increased to 1000 mg for 6 weeks and increased to 1500 mg for 6 weeks and increased to 2000 mg for the remaining 6 weeks on treatment
    Intervention: Drug: Resveratrol
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Recruiting
Estimated Enrollment  ICMJE
 (submitted: September 7, 2018)
68
Original Estimated Enrollment  ICMJE Same as current
Estimated Study Completion Date  ICMJE August 31, 2022
Estimated Primary Completion Date August 31, 2022   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  1. Served on active military duty and deployed to the Persian Gulf region August 1990 - July 1991;
  2. English speaking and able to understand the consent form and study questionnaires;
  3. Willing and able to be randomized to treatment and to commit to a 26-week study;
  4. Men and women between the ages of 44 to 68 (the number of 1990-1991 Gulf War Veterans who are older than 68 dramatically decreases because many of those with GWI have died prematurely);
  5. Meet the Kansas case definition for the diagnosis of GWI as well as the more inclusive CDC definition
  6. Stabilization on any psychiatric medication (≥3 months on selective serotonin reuptake inhibitor or monoamine oxidase inhibitor, ≥1 month on anxiolytic or beta-blockers);
  7. Female subjects of childbearing potential must test negative for pregnancy at the time of enrollment based on a serum pregnancy test and agree to use reliable method of birth control (for example, oral contraceptives or Norplant; a reliable barrier method of birth control [diaphragms with contraceptive jelly; cervical caps with contraceptive jelly; condoms with contraceptive foam]; intrauterine devices; partner with vasectomy; or abstinence) during the study. Note that this inclusion criterion applies only to females of childbearing potential. Females of childbearing potential are defined as women not surgically sterilized and between menarche and 2 years post-menopause.

Exclusion Criteria:

  1. Unstable or poorly controlled diabetes type II (HbA1C >9.0);
  2. Cancer;
  3. Lifetime diagnosis of schizophrenia or bipolar disorder or a history of psychiatric hospitalization for, or current diagnosis (i.e., the past 6 months) of substance dependence;
  4. Major depressive disorder or posttraumatic stress disorder requiring hospitalization;
  5. Significant CNS disease including TIAs or stroke, dementia, syncopal episodes, severe head trauma, multiple sclerosis;
  6. Serious or advanced heart disease or clinically relevant abnormal electrocardiogram (ECG) or postural hypotension;
  7. Untreated sleep apnea or body mass index (BMI) placing patients at risk for undiagnosed sleep apnea (BMI≥35 kg/m2);
  8. Subjects with renal insufficiency or chronic renal disease defined by national Kidney Foundation Disease Outcome Quality Initiative criteria (2000) with a GFR less than or equal to 90 mL/min/1.73m2. Laboratory monitoring of CR and Bun and eGFR will be obtained at baseline and prior to each titration and at study end or early termination. If Cr and Bun increase above upper limit of normal and eGFR drops to <45 or more than 35% the study drug will be discontinued and a nephrology consult will be ordered;
  9. Liver enzymes >3 times normal on 3 consecutive laboratory tests; evidence of significant hepatocellular injury as evidenced by elevated serum levels of aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 3 times the upper limit of normal (ULN); total or indirect bilirubin greater than 1.2 x ULN; alkaline phosphatase greater than 1.5 x ULN; prothrombin time (PT) as INR greater than 2.4 x ULN; or albumin less than 1 times the lower limit of normal (LLN) at baseline. Resveratrol is only anticipated to affect LFTs indirectly, by slowing statin metabolism. Persistent significant elevation of amino transferases are defined as >3x normal of normal upper limit on 2 consecutive measurements. Under the conditions of high dose statin therapy, it is typically addressed by temporarily stopping statin administration, then slowly titrating the dose back up under careful observation. Failure to reduce aminotransferase levels after the temporary cessation of statins (and a third LFT measurement is taken) would necessitate cessation of resveratrol treatment.
  10. Use of cytochrome P450 3A4 substrates with high risk of toxicity (e.g., terfenadine, cisapride, astemizole, disopyramide, amiodarone, dronedarone, colchicine, cyclosporine, quinidine, pimozide, cisapride, amlodipine, felodipine, nicardipine, nifedipine, nisoldipine, nitrendipin, nimodipine and verapamil);
  11. Use of blood thinners (e.g., Coumadin);
  12. Use of resveratrol-containing supplements.

    Participation in the scanning portion of the study is not required to participate in the clinical trial. Subjects who are interested in the scanning study will be asked to sign a second consent and will be screened for MRI-specific exclusion criteria. The additional exclusion criteria for participating in the MRI portion are listed below.

  13. General medical conditions that would prevent the participant from completing MRI scanning (active seizure disorder, dementia, active back or muscle spasms);
  14. Positive MRI safety screen for metal or history of penetrating head or eye wound without subsequent radiological evidence that the wound is metal-free;
  15. Participants that are (were) welders or that have had metal surgically removed from their eyes without radiological evidence that the wound is metal-free;
  16. MRI quality problems (tremors, significant claustrophobia);
  17. Shrapnel or other metal embedded in the body;
  18. Implanted orthopedic devices (e.g., metal rods, plates or screws but excluding nonferrous material);
  19. Implanted metal devices or prosthetics, or mechanical implants (e.g., pacemakers, electrical implants, cochlear implants);
  20. Implanted contraceptive devices (excluding those made of nonferrous material);
  21. Outside devices made of metal (e.g., neck braces, surgical staples, or artificial limbs), or non-removable dentures, braces or other metal orthodontics;
  22. Tattoos not done professionally or non-removable body piercings.
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 44 Years to 68 Years   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE
Contact: Tabitha Alverio, M.A. 254.297.3259 Tabitha.Alverio@va.gov
Contact: Laura Constable, M.A. 254.297.3954 Laura.Constable@va.gov
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT03665740
Other Study ID Numbers  ICMJE GW160050
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product
Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
IPD Sharing Statement  ICMJE
Plan to Share IPD: No
Responsible Party Dena Davidson, VISN 17 Center of Excellence
Study Sponsor  ICMJE VISN 17 Center of Excellence
Collaborators  ICMJE
  • Texas A&M University
  • Baylor University
  • KR Love Quantitative Consulting and Collaboration
Investigators  ICMJE
Principal Investigator: Dena Davidson, Ph.D. VISN 17 Center of Excellence
PRS Account VISN 17 Center of Excellence
Verification Date September 2018

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP