The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels

• ClinicalTrials.gov Identifier: NCT02913079
• Recruitment Status: Completed
• First Posted: September 23, 2016
• Last Update Posted: October 17, 2018
• Sponsor: University of Prince Edward Island
• Information provided by (Responsible Party): Travis Saunders, University of Prince Edward Island

Tracking Information

• First Submitted Date: September 15, 2016
• First Posted Date: September 23, 2016
• Last Update Posted Date: October 17, 2018
• Study Start Date: September 2016
• Actual Primary Completion Date: June 2018 (Final data collection date for primary outcome measure)

Current Primary Outcome Measures (submitted: September 20, 2016)

Postprandial Glucose [ Time Frame: 12 hours ]

Postprandial glucose will be assessed over 1 workday in both the experimental and control conditions.

• Original Primary Outcome Measures: Same as current

Current Secondary Outcome Measures (submitted: September 20, 2016)

• Objectively measured minutes of light, moderate and vigorous physical activity. [ Time Frame: 24 hours ]
  Physical activity time will be assessed over 1 workday during both conditions.
• Objectively measured minutes of sitting [ Time Frame: 24 hours ]
  Sitting time will be assessed over 1 workday during both conditions.

• Original Secondary Outcome Measures: Same as current
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels
• Official Title: The Acute Impact of Sit-stand Desks on Post-meal Blood Sugar Levels
• Brief Summary: Context and Rationale: Uninterrupted sitting is associated with increased risk of diabetes, heart disease, and death, even among people who are physically active. These relationships are likely due to increases in post-meal blood sugar observed when people sit for long periods (e.g. > 1 hour) without interruption. In contrast to sitting, standing results in large reductions in post-meal blood sugar levels. Our group has recently shown that sit-stand desks result in large (e.g. 2.5 hour/day) reductions in occupational sitting time. Taken together, these findings suggest that sit-stand desks may help to reduce post-meal blood sugar levels. However, this has yet to be examined in the field. Theoretical Approach and Objectives: The objective of this randomized crossover study is to determine whether people have lower blood sugar when using a sit-stand desk, in comparison to a desk that can only be used while sitting. Methods and Procedures: Sixteen participants will be asked to wear a continuous glucose monitor to measure their blood sugar levels during 2 separate conditions. During one condition, they will be asked to use a sit-stand desk to sit and/or stand as much as they like during 1 workday. During the other condition, they will be asked to work at a seated desk for 1 workday. Participants will be provided with identical meals to eat during each of the two conditions. We hypothesize that participants will have lower blood sugar levels on the day when they use the sit-stand desk, in comparison to the day using a traditional seated desk. Significance and Future Use: If our results support this hypothesis, this would suggest that sit-stand desks may be a useful way to reduce blood sugar levels in people at risk for diabetes. This could also lead to larger population-based interventions studying the health impact of sit-stand desks.
• Detailed Description: Not Provided
• Study Type: Interventional
• Study Phase: Not Applicable
• Study Design: Allocation: Randomized; Intervention Model: Crossover Assignment; Masking: None (Open Label); Primary Purpose: Basic Science

Condition

• Insulin Sensitivity
• Glucose Tolerance
• Sedentary Behaviour
• Physical Activity

Intervention

• Behavioral: Sit-stand desk
• Behavioral: Sitting desk

Study Arms

• Experimental: Sit-stand desk
  During this condition, participants will sit or stand as much as they like throughout a workday.
  Intervention: Behavioral: Sit-stand desk
• Placebo Comparator: Sitting
  During this condition, participants will work in the sitting position only.
  Intervention: Behavioral: Sitting desk

• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Completed
• Actual Enrollment (submitted: October 12, 2018): 14
• Original Estimated Enrollment (submitted: September 20, 2016): 25
• Actual Study Completion Date: September 2018
• Actual Primary Completion Date: June 2018 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

• To participate in this study, participants must be between the ages of 20 and 65, and have access to a sit-stand desk (depending on your workspace, we may be able to provide you with a sit-stand desk during the study if you do not already have one).

Exclusion Criteria:

• Participants will be excluded if they are currently taking any diabetes medications targeting blood sugar or insulin sensitivity as this will impact our primary outcome of postprandial glucose. Participants will also be excluded if they are unable to stand or walk independently, as these are secondary outcomes in the present study.

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 20 Years to 65 Years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: Canada

Administrative Information

• NCT Number: NCT02913079
• Other Study ID Numbers: 6006774
• Has Data Monitoring Committee: No
• U.S. FDA-regulated Product: Not Provided

IPD Sharing Statement

• Plan to Share IPD: No
• Plan Description: No.

• Responsible Party: Travis Saunders, University of Prince Edward Island
• Study Sponsor: University of Prince Edward Island
• Collaborators: Not Provided
• Investigators: Not Provided
• PRS Account: University of Prince Edward Island
• Verification Date: October 2018