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Review of Human Herpes Viruses in Burns

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ClinicalTrials.gov Identifier: NCT02452229
Recruitment Status : Completed
First Posted : May 22, 2015
Last Update Posted : May 22, 2015
Sponsor:
Collaborator:
Shriners Hospitals for Children
Information provided by (Responsible Party):
The University of Texas Medical Branch, Galveston

Tracking Information
First Submitted Date May 14, 2015
First Posted Date May 22, 2015
Last Update Posted Date May 22, 2015
Study Start Date March 2015
Actual Primary Completion Date May 2015   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: May 19, 2015)
Prevalence of Human Herpes Virus (HHV) Infections [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months. ]
HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures
 (submitted: May 19, 2015)
Treatment of Human Herpes Virus (HHV) Infections [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months. ]
Original Secondary Outcome Measures Same as current
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Review of Human Herpes Viruses in Burns
Official Title Human Herpes Viruses in Burn Victims: A Systematic Review
Brief Summary Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.
Detailed Description

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.

Study Type Observational
Study Design Time Perspective: Retrospective
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Non-Probability Sample
Study Population Every year, about 500,000 citizens of the United States of America were burned; 50,000 of them were admitted to Burn Center. Bacterial and viral infections including cellulitis, pneumonia, wound infections and septicemia are among the top ten complications of burn injuries. Severe burn injury causes an increased inflammatory response and an overall immunosuppression. As a result severely burned patients are more prone to infections and septicemia. Early treatment of sepsis and prevention of infections are key to reducing morbidity and improving the long-term outcome of burn victims.
Condition
  • Human Herpes Virus
  • Herpes Simplex Virus
  • Varicella-zoster Virus
  • Chickenpox
  • Cytomegalovirus
  • Burns
Intervention Other: Review of the Literature for Human Herpes Virus infections

Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface.

PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.

Study Groups/Cohorts Burn patients
The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.
Intervention: Other: Review of the Literature for Human Herpes Virus infections
Publications * Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg. 2010;8(5):336-41. doi: 10.1016/j.ijsu.2010.02.007. Epub 2010 Feb 18. Erratum in: Int J Surg. 2010;8(8):658.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: May 19, 2015)
10267
Original Actual Enrollment Same as current
Study Completion Date Not Provided
Actual Primary Completion Date May 2015   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Patients who presented with at least 1% TBSA burned
  • Patients who presented with a viral infections during their hospitalization

Exclusion Criteria:

  • Patients who had no burns
  • Patients who had no viral infections during their hospitalization
Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Not Provided
Removed Location Countries  
 
Administrative Information
NCT Number NCT02452229
Other Study ID Numbers SHC-G-SR-HHV
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party The University of Texas Medical Branch, Galveston
Study Sponsor The University of Texas Medical Branch, Galveston
Collaborators Shriners Hospitals for Children
Investigators
Study Chair: David N Herndon, MD, FACS Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA
PRS Account The University of Texas Medical Branch, Galveston
Verification Date May 2015