Epidemiological Study on Community Acquired Pneumonia (CAPNETZ)

• ClinicalTrials.gov Identifier: NCT02139163
• Recruitment Status: Recruiting
• First Posted: May 15, 2014
• Last Update Posted: July 31, 2020
• Sponsor: Hannover Medical School
• Information provided by (Responsible Party): Hannover Medical School

Tracking Information

• First Submitted Date: January 24, 2014
• First Posted Date: May 15, 2014
• Last Update Posted Date: July 31, 2020
• Study Start Date: October 2002
• Estimated Primary Completion Date: January 2021 (Final data collection date for primary outcome measure)

Current Primary Outcome Measures (submitted: May 12, 2014)

• diagnosis [ Time Frame: 2 weeks ]
  Assessment of diagnosis: Patients will be asked for example, about their diagnosis, comorbidities, specific risk factors and pneumonia symptoms.
• therapy [ Time Frame: 2 weeks ]
  Assessment of therapy: Patients will be asked about their therapy due to pneumonia symptoms, previous therapy, medication History etc.
• hospitalization [ Time Frame: 2 weeks ]
  Assessment of hospitalization: Patients will be asked about hospitalization, date, time and duration of hospitalization due to pneumonia symptoms.

• Original Primary Outcome Measures: Same as current
• Current Secondary Outcome Measures: Not Provided
• Original Secondary Outcome Measures: Not Provided
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: Epidemiological Study on Community Acquired Pneumonia
• Official Title: Epidemiological Study on Community Acquired Pneumonia
• Brief Summary: Long-term objectives of the basic research part are improvement of CAP-management with respect to therapy, diagnosis and prevention to contribute to a better care of patients with pneumonia.
• Detailed Description: Long-term objectives of the basic research part are improvement of CAP-management with respect to therapy, diagnosis and prevention to contribute to a better care of patients with pneumonia. The aim of the study CAPNETZ is to improve diagnosis, treatment and patient care.
• Study Type: Observational [Patient Registry]
• Study Design: Observational Model: Cohort; Time Perspective: Prospective
• Target Follow-Up Duration: 6 Months
• Biospecimen: Not Provided
• Sampling Method: Non-Probability Sample
• Study Population: patients with pneumonia
• Condition: Community Acquired Pneumonia
• Intervention: Other: Cohort Study

Study Groups/Cohorts

patients with pneumonia

Intervention: Other: Cohort Study

Publications *

• Zobel K, Martus P, Pletz MW, Ewig S, Prediger M, Welte T, Bühling F; CAPNETZ study group. Interleukin 6, lipopolysaccharide-binding protein and interleukin 10 in the prediction of risk and etiologic patterns in patients with community-acquired pneumonia: results from the German competence network CAPNETZ. BMC Pulm Med. 2012 Feb 20;12:6. doi: 10.1186/1471-2466-12-6.
• Klapdor B, Ewig S, Schaberg T, Rohde G, Pletz MW, Schütte H, Welte T; CAPNETZ study group. Presentation, etiology and outcome of pneumonia in younger nursing home residents. J Infect. 2012 Jul;65(1):32-8. doi: 10.1016/j.jinf.2012.02.003. Epub 2012 Feb 10.
• Lepper PM, Ott S, Nüesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Jüni P, Bals R, Rohde G; German Community Acquired Pneumonia Competence Network. Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study. BMJ. 2012 May 28;344:e3397. doi: 10.1136/bmj.e3397.
• Kolditz M, Höffken G, Martus P, Rohde G, Schütte H, Bals R, Suttorp N, Pletz MW; CAPNETZ study group. Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study. BMC Infect Dis. 2012 Apr 13;12:90. doi: 10.1186/1471-2334-12-90.
• Klapdor B, Ewig S, Pletz MW, Rohde G, Schütte H, Schaberg T, Welte T; CAPNETZ Study Group. Community-acquired pneumonia in younger patients is an entity on its own. Eur Respir J. 2012 May;39(5):1156-61. doi: 10.1183/09031936.00110911. Epub 2011 Nov 16. Erratum in: Eur Respir J. 2012 Dec;40(6):1583.
• Ewig S, Klapdor B, Pletz MW, Rohde G, Schütte H, Schaberg T, Bauer TT, Welte T; CAPNETZ study group. Nursing-home-acquired pneumonia in Germany: an 8-year prospective multicentre study. Thorax. 2012 Feb;67(2):132-8. doi: 10.1136/thoraxjnl-2011-200630. Epub 2011 Nov 5.

Recruitment Information

• Recruitment Status: Recruiting
• Estimated Enrollment (submitted: May 12, 2014): 10150
• Original Estimated Enrollment: Same as current
• Estimated Study Completion Date: January 2022
• Estimated Primary Completion Date: January 2021 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

• age ≥ 18
• infiltrate on chest X-ray
• further Inclusion criteria: cough or production of purulent sputum or pathologic lung auscultation (crackles) or fever

Exclusion Criteria:

• hospital inpatient treatment within the last 28 days
• Immune suppressed patients

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

Contacts

Contact: Tobias Welte, Prof.; +49-511-532-5927; office@capnetz.de

• Listed Location Countries: Germany

Administrative Information

• NCT Number: NCT02139163
• Other Study ID Numbers: U1111-1147-8393
• Has Data Monitoring Committee: No
• U.S. FDA-regulated Product: Not Provided
• IPD Sharing Statement: Not Provided
• Responsible Party: Hannover Medical School
• Study Sponsor: Hannover Medical School
• Collaborators: Not Provided

Investigators

• Study Chair: Tobias Welte, Prof. Dr.; Hannover Medical School

• PRS Account: Hannover Medical School
• Verification Date: July 2020