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On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction (PLATFORM)

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ClinicalTrials.gov Identifier: NCT01739556
Recruitment Status : Terminated (An interim analysis showed that there is no difference in the primary endpoint, given the small number of events in the groups examined.)
First Posted : December 3, 2012
Last Update Posted : July 18, 2018
Sponsor:
Information provided by (Responsible Party):
Igor Mrdovic, Clinical Centre of Serbia

Tracking Information
First Submitted Date  ICMJE November 22, 2012
First Posted Date  ICMJE December 3, 2012
Last Update Posted Date July 18, 2018
Study Start Date  ICMJE June 2015
Actual Primary Completion Date January 2018   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: November 30, 2012)
MACE [ Time Frame: up to 1 year ]
The PLATFORM specified primary efficacy end point is the time to first occurrence of any component of the composite MACE (comprising total death, nonfatal infarction, nonfatal stroke and immediate target vessel revascularization).
Original Primary Outcome Measures  ICMJE Same as current
Change History Complete list of historical versions of study NCT01739556 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures  ICMJE
 (submitted: November 30, 2012)
  • Total death [ Time Frame: up to 1 year ]
    total mortality rate
  • Major bleeding [ Time Frame: up to 1 year ]
    TIMI major bleeding unrelated to coronary artery bypass graft surgery
  • Total bleeding [ Time Frame: up to 1 year ]
    all bleeding events
  • Reinfarction [ Time Frame: up to 1 year ]
    nonfatal myocardial infarction
  • Stroke [ Time Frame: up to 1 year ]
    nonfatal cerebrovascular insult
  • Revascularisation [ Time Frame: up to 1 year ]
    ischemia-driven target vessel revascularization
  • Transfusion [ Time Frame: up to 1 year ]
    need for bood transfusion
Original Secondary Outcome Measures  ICMJE Same as current
Current Other Pre-specified Outcome Measures
 (submitted: November 30, 2012)
Stent thrombosis [ Time Frame: up to 1 year ]
definite stent thrombosis
Original Other Pre-specified Outcome Measures Same as current
 
Descriptive Information
Brief Title  ICMJE On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction
Official Title  ICMJE On-treatment PLAtelet Reactivity-guided Therapy Modification FOR ST-segment Elevation Myocardial Infarction (PLATFORM)
Brief Summary

Adequate platelet inhibition with dual antiplatelet therapy is a key therapeutic goal after primary percutaneous coronary intervention (PPCI), aimed at protecting against stent thrombosis and increased mortality. Recent aggregometric assays have shown that up to one third of acute coronary syndrome patients treated with clopidogrel have incomplete inhibition of adenosine diphosphate(ADP)-induced platelet aggregation while the number of patients treated with aspirin who have incomplete inhibition of thromboxane A2-induced platelet aggregation (ASPI)is much lower. High on-treatment platelet reactivity (HTPR) has been associated with an increased rate of ischemic events after PCI. However, recent large trials did not show a clinical benefit of TPR-guided therapy modification in acute coronary syndrome patients treated by PCI.

On-treatment PLAtelet reactivity-guided Therapy modification FOR ST-segment elevation Myocardial infarction (PLATFORM) is an investigator-initiated, prospective, randomized, parallel-group, controlled clinical trial designed to test the hypothesis that antiplatelet therapy modification is superior to standard antiplatelet regimen among intermediate to high-risk STEMI patients undergoing PPCI. The safety hypothesis is that compared with control arm, interventional study arm will have similar rates of non-coronary artery bypass graft surgery-related bleeding. Approximately 632 ST-elevation myocardial infarction (STEMI) patients with intermediate to high-risk (RISK-PCI score >3) clinical features undergoing PPCI will be randomly allocated to treatment modification or standard treatment. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year. Patients will be followed up to 1 year after PPCI.

Detailed Description

On-treatment PLAtelet reactivity-guided Therapy modification FOR ST-segment elevation Myocardial infarction (PLATFORM) is an investigator-initiated, prospective, open-label, randomized, parallel-group, actively controlled single-centre clinical trial. The research protocol has been approved by the Ethics Committee of the Clinical Centre of Serbia. All participants will have to provide their informed consent in writing. The trial design will ensure that all participants abide by good clinical practice and the ethical principles of the Declaration of Helsinki II. Patients will be randomly allocated to antiplatelet regimen modification (ARM, interventional arm) or standard treatment (control arm) using a computer-generated 1:1 simple randomization scheme. TPR will be assessed in patients enrolled in the intervention arm of the trial. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year. Patients enrolled in the control arm will receive standard antiplatelet regimen including 100 mg aspirin and 75 mg clopidogrel without assessment of TPR. The treating physicians will not be blinded to the intervention since an open design will make it possible for investigators to perform necessary adjustments of the antiplatelet regimen in accordance with TPR status. To minimize any possible bias inherent in the open design, endpoints will be evaluated by a blinded endpoint committee. Enrollment will start in June 2013. Recruitment will continue until 632 patients have been randomized. The end of the recruitment period is planned for June 2015. The trial will continue until all available survivors have been followed for at least 1 year.

Aspirin 300 mg and clopidogrel 600 mg loading doses will be administered as early as possible before PPCI. Primary PCI will be performed via femoral or radial approach, using standard 6 French-7 French guiding catheters. The Thrombolysis in Myocardial Infarction (TIMI) blood flow will be measured by two experienced observers blinded to identity and the order of angiograms. Any disagreement will be resolved by a third observer. Unfractionated heparin will be started as 100 IU/kg bolus (60 IU/kg if glycoprotein (GP)IIb/IIIa receptor inhibitor was used); the 12 IU/kg/h infusion will follow if clinically indicated. Proton-pump inhibitor pantoprazole or H2-blocker ranitidine will be given to selected patients at risk for gastrointestinal hemorrhage. GP IIb/IIIa receptor inhibitor tirofiban will be administered during the procedure in patients with evidence of high intracoronary thrombus burden according to the European Society of Cardiology guidelines.

Multiple electrode aggregometry will be performed using the impedance aggregometer and under the monitoring of an official representative of the manufacturer (Multiplate analyzer, Verum-Diagnostics, Munich, Germany). TPR results will be evaluated by 2 investigators who will be blinded to patient's identity and treatment. Whole blood will be sampled 24 hours after the loading dose. In patients who received IIb/IIIa inhibitor tirofiban blood samples will be obtained at least 24 hours after the completion of tirofiban infusion. On-treatment platelet reactivity (TPA) above 50%, compared to the basal value estimated by TRAP test, will be linked with low responsiveness.

Patients will be followed-up after discharge from hospital for net adverse events up to 1 year after enrolment by scheduled telephone interviews and outpatient visits. Interviewers will be blinded to the randomization scheme and to the results of platelet aggregation. An independent Clinical Event Committee, composed of 3 cardiologists and 1 neurologist and blinded with respect to randomization allocation will review and adjudicate the occurrence of each suspected clinical end point. Interim analyses of efficacy and futility, using O'Brian-Fleming guidelines for group sequential design, are planned when one fourth, one half and three fourths of the maximum number of the 632 patients had been followed-up for 30 days. Interim analyses and all safety data will be reviewed by an independent Data Safety and Monitoring Committee, composed of a chairman, a statistician, and 2 physician members.

Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 3
Study Design  ICMJE Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Condition  ICMJE Acute ST-elevation Myocardial Infarction
Intervention  ICMJE Drug: Antiplatelet Regimen Modification (aspirin or ticagrelor)
Study Arms  ICMJE
  • Experimental: Intervention Arm
    Antiplatelet regimen modification will be guided by assessment of the on-treatment platelet reactivity. Low responders to aspirin will receive 200 mg aspirin for 30 days. Low responders to clopidogrel will receive 180 mg ticagrelor for 1 year.
    Intervention: Drug: Antiplatelet Regimen Modification (aspirin or ticagrelor)
  • No Intervention: Standard Treatment
    Patients enrolled in the Standard Treatment arm will receive standard antiplatelet regimen including 100 mg aspirin and 75 mg clopidogrel without assessment of on-treatment platelet reactivity.
Publications * Mrdovic I, Savic L, Krljanac G, Asanin M, Cvetinovic N, Brdar N, Stojanovic M, Djuricic N, Stankovic S, Marinkovic J, Perunicic J. Rationale and design of the on-treatment PLAtelet Reactivity-Guided Therapy Modification FOR ST-Segment Elevation Myocardial Infarction (PLATFORM) randomized trial. J Interv Cardiol. 2013 Jun;26(3):221-7. doi: 10.1111/j.1540-8183.2013.12024.x. Epub 2013 Feb 4.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Terminated
Actual Enrollment  ICMJE
 (submitted: July 17, 2018)
242
Original Estimated Enrollment  ICMJE
 (submitted: November 30, 2012)
632
Actual Study Completion Date  ICMJE January 2018
Actual Primary Completion Date January 2018   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  • 18 years and older, willing consent, undergoing primary PCI for STEMI, within 12 hours of the onset of symptoms, stent implanted successfully, RISK-PCI score for 30-day MACE >3, alive 24 hours after loading doses, ability to comply with study protocol, negative pregnancy test for women of childbearing potential before enrollment, agree to use a reliable method of birth control during the study

Exclusion Criteria:

  • Pre-procedural
  • history of hemorrhagic stroke
  • ischemic stroke within 30 days of randomization
  • evidence of active abnormal bleeding within 3 months of randomization
  • high risk for bleeding on long-term antiplatelet therapy
  • current therapy with coumadin anticoagulant
  • Pregnancy or nursing
  • current enrollment in another investigational study Procedural
  • balloon angioplasty without stent placement
  • unsuccessful PPCI (post-procedural TIMI flow 0) Post-procedural
  • active bleeding
  • hemoglobin <10 g/dL or drop in hemoglobin by ≥3 g/dL
  • platelet count <100 000 x 10-9/L.
  • TRAP value <500 aggregation units
  • indication for permanent anticoagulant therapy
  • need for urgent surgical revascularization
  • vascular pseudoaneurysm
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years to 90 Years   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE Serbia
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT01739556
Other Study ID Numbers  ICMJE CCS-553-12
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Igor Mrdovic, Clinical Centre of Serbia
Study Sponsor  ICMJE Clinical Centre of Serbia
Collaborators  ICMJE Not Provided
Investigators  ICMJE
Principal Investigator: Igor Mrdovic, Ph.D Clinical Centre of Sebria
Study Director: Jovan Perunicic, Ph.D Clinical Centre of Serbia
PRS Account Clinical Centre of Serbia
Verification Date February 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP