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Grass Sensitisation and Allergic Rhinitis in Thai Patients

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ClinicalTrials.gov Identifier: NCT01686022
Recruitment Status : Completed
First Posted : September 17, 2012
Last Update Posted : September 14, 2016
Sponsor:
Collaborator:
National Research Council of Thailand
Information provided by (Responsible Party):
Punchama Pacharn, Mahidol University

Tracking Information
First Submitted Date September 12, 2012
First Posted Date September 17, 2012
Last Update Posted Date September 14, 2016
Study Start Date October 2012
Actual Primary Completion Date October 2015   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History Complete list of historical versions of study NCT01686022 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Grass Sensitisation and Allergic Rhinitis in Thai Patients
Official Title The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients
Brief Summary Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.
Detailed Description

To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study.

The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

Study Type Observational
Study Design Not Provided
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples Without DNA
Description:
Serum
Sampling Method Non-Probability Sample
Study Population Allergy Clinic
Condition
  • Allergy to Grass Pollen
  • Allergic Rhinitis Due to Weed Pollens
Intervention Other: Immunoblot
serum specific IgE binds to grass extract by immunoblot
Study Groups/Cohorts Pollen Allergy
Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition
Intervention: Other: Immunoblot
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: September 13, 2016)
40
Original Estimated Enrollment
 (submitted: September 14, 2012)
185
Actual Study Completion Date October 2015
Actual Primary Completion Date October 2015   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Allergic rhinitis patients age 10-50 years old
  • Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

  • Chronic illness such as cardiovascular diseases, liver diseases
  • History of anaphylaxis
  • Pregnancy
Sex/Gender
Sexes Eligible for Study: All
Ages 10 Years to 50 Years   (Child, Adult)
Accepts Healthy Volunteers Yes
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Thailand
Removed Location Countries  
 
Administrative Information
NCT Number NCT01686022
Other Study ID Numbers NRCT_G04
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement
Plan to Share IPD: Undecided
Responsible Party Punchama Pacharn, Mahidol University
Study Sponsor Mahidol University
Collaborators National Research Council of Thailand
Investigators
Principal Investigator: Punchama Pacharn, MD Mahidol University
PRS Account Mahidol University
Verification Date September 2016