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Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT01128959
Recruitment Status : Completed
First Posted : May 24, 2010
Results First Posted : December 5, 2016
Last Update Posted : January 16, 2018
Sponsor:
Collaborators:
Ligand Pharmaceuticals
ICON Clinical Research
Quintiles, Inc.
Information provided by (Responsible Party):
Lundbeck LLC

Tracking Information
First Submitted Date  ICMJE May 21, 2010
First Posted Date  ICMJE May 24, 2010
Results First Submitted Date  ICMJE October 10, 2016
Results First Posted Date  ICMJE December 5, 2016
Last Update Posted Date January 16, 2018
Study Start Date  ICMJE June 2010
Actual Primary Completion Date January 2013   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: December 12, 2016)
Adverse Events [ Time Frame: Baseline to after last iv dose on day 4 ]
Original Primary Outcome Measures  ICMJE
 (submitted: May 21, 2010)
The primary objective to assess the safety and tolerability of IV CBZ administered as multiple 15 minute infusions to adult patients with epilepsy on stable higher doses of oral CBZ includes adverse events, laboratory test results, and ECG parameters [ Time Frame: 13 infusions administered across 4 days ]
Change History Complete list of historical versions of study NCT01128959 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures  ICMJE Not Provided
Original Secondary Outcome Measures  ICMJE
 (submitted: May 21, 2010)
For the secondary objective to assess biomarkers for renal effect of IV CBZ, the variables of interest include the analytes collected in the 24-hour urine collection relative to the creatinine volume excreted [ Time Frame: Measures will be taken across all days of IV infusion (4 days) ]
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Study to Assess the Safety and Tolerability of Intravenous Carbamazepine in Adults With Epilepsy
Official Title  ICMJE Open-Label Study to Assess the Safety and Tolerability of Intravenous Carbamazepine as Short-Term Replacement of Oral Carbamazepine in Adult Patients With Epilepsy
Brief Summary The purpose of this study is to assess the safety and tolerability of intravenous (IV) carbamazepine (CBZ) administered as multiple 15 minute infusions and a single 5 minute infusion to adult patients with epilepsy on stable higher doses of oral CBZ.
Detailed Description

This was a phase III, multicenter, open-label study designed to assess the safety and tolerability of intravenously administered CBZ in adult patients with epilepsy. This study included a 28 day Lead-in Period, a Confinement Period (up to 7 days and 6 nights) and a 28 day Follow-up Period.

Patients began confinement on Day -1 of the trial, continuing to take their oral CBZ as prescribed by the investigator. On the morning of Day 0, Day 4, and Day 17, patients began the 24hr urine collection for evaluation of urinary biomarkers. All patients temporarily discontinued their prescribed oral CBZ and begin IV CBZ administration on the morning of Day 1, continuing administrations every 6 hours (Q6h) through the morning of Day 4.

Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 3
Study Design  ICMJE Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Condition  ICMJE Epilepsy
Intervention  ICMJE Drug: Intravenous Carbamazepine (IV CBZ)
10 mg/mL of IV CBZ dissolved in 250 mg/mL of Captisol® (sulfobutylether-beta-cyclodextrin) dosed at 70% of the patient's daily maintenance dose of oral CBZ administered after suitable dilution with D5W by IV infusion every 6 hours.
Study Arms  ICMJE Experimental: Intravenous Carbamazepine (IV CBZ)
Intervention: Drug: Intravenous Carbamazepine (IV CBZ)
Publications * Lee D, Kalu U, Halford JJ, Biton V, Cloyd J, Klein P, Bekersky I, Peng G, Dheerendra S, Tolbert D. Intravenous carbamazepine as short-term replacement therapy for oral carbamazepine in adults with epilepsy: Pooled tolerability results from two open-label trials. Epilepsia. 2015 Jun;56(6):906-14. doi: 10.1111/epi.12991. Epub 2015 Apr 25.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: January 15, 2013)
108
Original Estimated Enrollment  ICMJE
 (submitted: May 21, 2010)
105
Actual Study Completion Date  ICMJE January 2013
Actual Primary Completion Date January 2013   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  1. The patient or legal representative must be able to read, understand, sign and date the IRB approved Informed Consent Form and HIPAA Authorization prior to study participation.
  2. The patient is a man or a non-pregnant woman who is at least 18 years of age.
  3. If a woman:

    • Patient is either not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile (bilateral tubal ligation, bilateral oophorectomay or hysterectomy), or if childbearing potential, must comply with a method of birth control acceptable to the investigator during the study, for at least 28 days prior to Day 1 and for 28 days following completion of the study.
    • Patient is not breastfeeding.
    • Patient of childbearing potential must have a negative serum pregnancy test at Day -28 and a negative urine pregnancy test or serum pregnancy test at Day -1.
  4. The patient is diagnosed with any of the approved epilepsy indications for CBZ:

    • Partial seizures with complex symptomatology (psychomotor, temporal lobe)
    • Generalised tonic clonic seizures (GTCS) (grand mal): myoclonic, clonic, tonic, tonic-clonic, atonic
    • Mixed seizure patterns that include the above, or other partial or generalised seizures (except absence seizures - please see exclusion point number 12)
  5. The patient is receiving a stable dose of oral CBZ (tablet or capsule formulation) of 1200 mg/day to 2000 mg/day, for a minimum of 14 days prior to Day -28.
  6. The patient is receiving a constant dose of all other concomitant medications used for chronic conditions, (including OTC medications and herbal supplements) for a minimum of 28 days prior to Day 1.
  7. The patient is not expected to have any change in his/her baseline AED treatment during the treatment period.
  8. The patient is able to comply with maintaining an accurate Seizure and antiepileptic drug diary.
  9. The patient is able to comply with all study procedures including complying with protocol determined dosing intervals, confinement at the investigative site for up to 6 nights and 7 days, and agrees to participate in the entire study.

Exclusion Criteria:

  1. The patient has a known hypersensitivity to CBZ, Captisol, or to any of the tricyclic compounds, such as amitriptyline, trimipramine, imipramine; oxacarbazepine, phenytoin, or their analogues or metabolites.
  2. The patient has a history of previous bone marrow depression.
  3. The patient has a history of intolerance to IV administration of medication.
  4. The patient is pregnant or lactating.
  5. The patient is being treated with a monoamine oxidase (MAO) inhibitor.
  6. The patient is using oral, intramuscular, or any other hormone delivery method as their primary form of birth control.
  7. The patient has an ECG with corrected QT interval by Fridericia's correction formula (QTcF) greater than 450 msec at Screening or Day -1.
  8. The patient has a screening ALT, AST or bilirubin >=3 times the upper limit of normal.
  9. The patient has an estimated ClCR (based of Cockcroft-Gault) of <50 ml/min.
  10. The patient has had a clinically significant illness/infection or has had any surgical procedure within 30 days prior to Screening.
  11. The patient has a significant history of cardiac, renal, neurologic (other than epilepsy), psychiatric, oncologic, endocrinologic, metabolic, or hepatic disease, which would adversely affect their participation in this study.
  12. The patient is receiving oral CBZ for absence seizures.
  13. The patient has had an episode of status epilepticus within 4 weeks of Screening.
  14. The patient has a history of severe or serious adverse reactions to CBZ (for example, aplastic anemia, agranulocytosis, SJS.
  15. The patient has taken or used any investigational drug or device in the 30 days prior to Screening.
  16. The patient has previously been administered IV CBZ in a previous clinical trial (for example OV-1015).
  17. The patient has a urine toxicology screen positive for phencyclidine, benzodiazepines (unless due to the patient's concomitant AEDs), cannabinoids, cocaine, amphetamines, opiates, barbiturates (unless due to the patient's concomitant AEDs), or alcohol at Screening or Day -1.
  18. The patient has had a diagnosis of drug or alcohol abuse within the past year prior to Screening.
  19. The patient has had significant blood loss (>500 mL) or donation within 14 days of Screening.
  20. The patient has a history of poor oral CBZ compliance.
  21. The patient is participating in a weight loss or nicotine cessation program.
  22. The patient has a history of increased intraocular pressure or is on medication for glaucoma.
  23. The patient is considered by the investigator to be an unsuitable candidate for the study, which may include an increase in the frequency, severity and duration of seizures during the Pre-Treatment Period (Days -28-0).
  24. The patient has previously participated in this study.
  25. The patient is a member of the site personnel or their immediate families.
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT01128959
Other Study ID Numbers  ICMJE 13181A
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Lundbeck LLC
Study Sponsor  ICMJE Lundbeck LLC
Collaborators  ICMJE
  • Ligand Pharmaceuticals
  • ICON Clinical Research
  • Quintiles, Inc.
Investigators  ICMJE
Study Director: Email contact via H. Lundbeck A/S LundbeckClinicalTrials@lundbeck.com
PRS Account Lundbeck LLC
Verification Date December 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP