The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium

• ClinicalTrials.gov Identifier: NCT01086176
• Recruitment Status: Completed
• First Posted: March 12, 2010
• Last Update Posted: April 27, 2010
• Sponsor: Maisonneuve-Rosemont Hospital
• Information provided by: Maisonneuve-Rosemont Hospital

Tracking Information

• First Submitted Date: March 10, 2010
• First Posted Date: March 12, 2010
• Last Update Posted Date: April 27, 2010
• Study Start Date: March 2010
• Actual Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
• Current Primary Outcome Measures (submitted: March 11, 2010): The difference at 30 minutes after the post-tetanic count between the TOF% in both arms, we expect a difference of more than 10%
• Original Primary Outcome Measures: Same as current

Current Secondary Outcome Measures (submitted: March 11, 2010)

• The difference at 30 minutes after the post-tetanic count on the T1% (of the calibrated T1) in both arms, we expect a difference of more than 10%
• The difference of the slope of recuperation on TOF and T1% after a post-tetanic count vs the control arm that had no tetanic stimulation

• Original Secondary Outcome Measures: Same as current
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: The Impact of Post-tetanic Count on Subsequent Train-of-four During Recovery From Rocuronium
• Official Title: Not Provided
• Brief Summary: The purpose of this study is to see how long does the effect of a post-tetanic facilitation last on subsequent train-of-four. The investigators hypothesis is that the effect last at least 30 minutes.
• Detailed Description: Not Provided
• Study Type: Observational
• Study Design: Observational Model: Case-Control; Time Perspective: Prospective
• Target Follow-Up Duration: Not Provided
• Biospecimen: Not Provided
• Sampling Method: Non-Probability Sample
• Study Population: Poeple having general anesthesia at HMR
• Condition: Post-tetanic Count on One Arm, the Other Arm is the Control

Intervention

Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)

on one side, we do a post-tetanic count, on the other side we don't, after, we do train-of-four on both sides and check the difference

Study Groups/Cohorts

Patient-control

Intervention: Device: NMT (a device that can do neurostimulation and can record the response on the stimulation by Datex)

• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Completed
• Estimated Enrollment (submitted: March 11, 2010): 22
• Original Estimated Enrollment: Same as current
• Actual Study Completion Date: April 2010
• Actual Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

• Patient having general anesthesia in dorsal decubitus with both arm available for at least an hour and a half

Exclusion Criteria:

• Age >75 or <18
• Neuromuscular disease
• difficult laryngoscopy predicted
• Allergy to rocuronium
• Malignant hyperthermia
• Full stomach
• Drugs the influence neuromuscular blockers
• Decision of the clinician to exclude his patient

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years to 75 Years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: Canada

Administrative Information

• NCT Number: NCT01086176
• Other Study ID Numbers: MaisonneuveRH-09092
• Has Data Monitoring Committee: Not Provided
• U.S. FDA-regulated Product: Not Provided
• IPD Sharing Statement: Not Provided
• Responsible Party: Louis-Philippe Fortier MD Msc, HMR
• Study Sponsor: Maisonneuve-Rosemont Hospital
• Collaborators: Not Provided
• Investigators: Not Provided
• PRS Account: Maisonneuve-Rosemont Hospital
• Verification Date: March 2010