Working…
ClinicalTrials.gov
ClinicalTrials.gov Menu

Analyzing Composition and Lubrication Properties of Synovial Fluid (SFCL)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00912106
Recruitment Status : Completed
First Posted : June 3, 2009
Last Update Posted : June 3, 2009
Sponsor:
Collaborator:
National Science Concil
Information provided by:
Far Eastern Memorial Hospital

Tracking Information
First Submitted Date June 2, 2009
First Posted Date June 3, 2009
Last Update Posted Date June 3, 2009
Study Start Date April 2008
Actual Primary Completion Date December 2008   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: June 2, 2009)
Synovial fluid HA and albumin concentration; synovial fluid lubrication [ Time Frame: 1 wk, 2 wk, 3 wk, 4 wk, 5 wk ]
Original Primary Outcome Measures Same as current
Change History No Changes Posted
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Analyzing Composition and Lubrication Properties of Synovial Fluid
Official Title Boundary Lubrication of Synovial Fluid Molecules and Its Effect on the Surrounding Cells and Tissues
Brief Summary To analyze the relationship between composition of synovial fluid and its lubrication properties
Detailed Description Patients suffering from serious arthritis may receive the artificial joint replacement surgery. Comparing to the articulation of articular cartilage, the artificial joint undergo a boundary lubrication in which a thin layer of synovial fluid molecules is formed between the artificial joint materials. Therefore a larger wear rate is observed in the artificial joint system. Researchers have devoted themselves to modifying the artificial joint materials in order to reduce the wear phenomena. We first propose that modification the lubrication by adding effective lubricating molecules may help to reduce the wear of artificial joint. However, there still lacks fundamentally understanding of the artificial joint lubrication mechanism under synovial fluid. Hence, we plan to investigate the boundary lubrication mechanism of synovial molecules, such as albumin, globulin, hyaluronic acid, and lipid in the first year. We would like to obtain the adsorption behaviors of the single molecules as well as multiple molecules on the surfaces of artificial joint materials by experiments. Molecular dynamics simulation will also be performed to gain the knowledge of adsorption energy and possible conformation change of the molecules. In the second year, the tribological heat and mechanical effects on the synovial molecules will be studied. The analysis platform will be established to perform the composition and properties measurement of the synovial molecules. In the third year, we will further discuss the effect of the synovial molecules transformation on the surrounding cells and tissues. Their influences on the tribological and biochemical behaviors will be investigated.
Study Type Observational
Study Design Observational Model: Case-Control
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples Without DNA
Description:
synovial fluid from knee joint
Sampling Method Probability Sample
Study Population Patients who are going to receive HA injection of one or two knees
Condition
  • Knee Osteoarthritis
  • HA Injection
  • One Injection Per Week for Five Week
  • Synovial Fluid Composition
  • Synovial Fluid Lubrication
Intervention Other: Synovial fluid composition and lubrication analysis
Before HA injection, synovial fluid must be drawn to increase treatment effectiveness. The drawn synovial fluid was then analyzed in the lab. There was no influence for patients enrolled because the drawn synovial fluid would usually be discarded.
Study Groups/Cohorts HA injection
Patients with osteoarthritis of knee. They are going to received HA injection 1 vial per week for 5 weeks.
Intervention: Other: Synovial fluid composition and lubrication analysis
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: June 2, 2009)
55
Original Actual Enrollment Same as current
Actual Study Completion Date June 2009
Actual Primary Completion Date December 2008   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Patients who are going to receive HA injection of one or two knees

Exclusion Criteria:

  • Patients whose quantity of synovial fluid is not enough to be drawn
Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Taiwan
Removed Location Countries  
 
Administrative Information
NCT Number NCT00912106
Other Study ID Numbers 96024
NSC-96-
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Chih-Hung Chang, Division of Orthopedics, Far Eastern Memorial Hospital
Study Sponsor Far Eastern Memorial Hospital
Collaborators National Science Concil
Investigators
Study Director: Chih-Hung Chang, Ph. D Far Eastern Memorial Hospital
PRS Account Far Eastern Memorial Hospital
Verification Date June 2009