An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers

• ClinicalTrials.gov Identifier: NCT00806338
• Recruitment Status: Completed
• First Posted: December 10, 2008
• Last Update Posted: April 15, 2009
• Sponsor: Genaera Corporation
• Information provided by: Genaera Corporation

Tracking Information

• First Submitted Date: January 21, 2008
• First Posted Date: December 10, 2008
• Last Update Posted Date: April 15, 2009
• Study Start Date: November 2008
• Actual Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
• Current Primary Outcome Measures (submitted: December 9, 2008): Safety and Tolerance of multiple intravenous doses of trodusquemine (MSI-1436) in obese or overweight type 2 diabetics. Safety will be evaluated by physical exams, vital signs assessments, 12-lead ECGs, clinical lab tests and adverse event profile. [ Time Frame: 6 months ]
• Original Primary Outcome Measures: Same as current
• Change History: Complete list of historical versions of study NCT00806338 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures (submitted: December 9, 2008)

• Effect on glucose tolerance or glucose/insulin relationships [ Time Frame: 6 months ]
• Effect on appetite and food consumption [ Time Frame: 6 months ]
• Effect on behavior and mood [ Time Frame: 6 months ]
• Effect on exploratory biomarkers [ Time Frame: 6 months ]

• Original Secondary Outcome Measures: Same as current
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: An Ascending Multi-Dose, Tolerance and Pharmacokinetic Study in Obese or Overweight Type 2 Diabetic Volunteers
• Official Title: A Phase I, Double-Blind, Randomized, Placebo-Controlled Ascending IV Multiple Dose Tolerance and Pharmacokinetic Study of Trodusquemine (MSI-1436) in Obese or Overweight Type 2 Diabetic Volunteers
• Brief Summary: The purpose of this study is to evaluate the safety and tolerance of multiple intravenous (through a vein) doses of trodusquemine (MSI-1436) in obese or overweight, type 2 diabetics.
• Detailed Description: Different amounts of trodusquemine (MSI-1436) will be given to each volunteer group throughout the study. Another purpose is to evaluate the pharmacokinetics (PK - the study of the way the drug enters and leaves the blood and tissues over time) of trodusquemine (MSI-1436). Finally, this study will also determine whether trodusquemine (MSI-1436) has any effect on appetite, mood or behavior, and selective biomarkers (substances in your blood that may change in response to the study drug).
• Study Type: Interventional
• Study Phase: Phase 1
• Study Design: Allocation: Randomized; Intervention Model: Single Group Assignment; Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor); Primary Purpose: Treatment

Condition

• Diabetes Mellitus
• Obesity

Intervention

• Drug: Trodusquemine (MSI-1436)
  A single dose of Trodusquemine (MSI-1436) will be administered every 72 hours on Days 0, 3, 6, 9, 12, 15, 18 and 21. Doses are 3mg/m2 in cohort 1, 6mg/m2 in cohort 2 and 10mg/m2 in cohort 3.
• Drug: Placebo

Study Arms

• Experimental: Trodusquemine (MSI-1436) 3mg/m2
  Intervention: Drug: Trodusquemine (MSI-1436)
• Experimental: Trodusquemine (MSI-1436) 6mg/m2
  Intervention: Drug: Trodusquemine (MSI-1436)
• Experimental: Trodusquemine (MSI-1436) 10mg/m2
  Intervention: Drug: Trodusquemine (MSI-1436)
• Placebo Comparator: Placebo
  Intervention: Drug: Placebo

• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Completed
• Actual Enrollment (submitted: April 14, 2009): 22
• Original Estimated Enrollment (submitted: December 9, 2008): 21
• Actual Study Completion Date: April 2009
• Actual Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria:

1. male or female obese or overweight type 2 diabetic subjects, between 18 and 65 years old (inclusive) either treatment naïve or who are inadequately controlled on metformin alone;
2. subjects receiving metformin should be on stable dose for at least two weeks prior to enrollment;
3. have a fasting blood sugar of ≥ 100 mg/dL and hemoglobin A1C ≥ 7.5% (but ≤ 11.0%) at study entry;
4. of any race who are in good health (based on medical history, physical examination, electrocardiograms [ECGs], and clinical laboratory tests);
5. non-smokers (refrained from any tobacco or nicotine usage, including smokeless tobacco, nicotine patches, etc.,) for 6 months prior to Day 0 of the study. Subjects must have cotinine levels below those measured for smokers based on reference lab values;
6. body mass index (BMI) of 27-40 kg/m2;
7. able to execute informed written consent;
8. willingness to remain in the clinic for the inpatient portion of the study and return for follow-up visits as required by the protocol and as deemed necessary by the Principal Investigator;

Exclusion Criteria:

1. likely allergy or sensitivity to any components of Trodusquemine (MSI-1436C) for Injection;
2. any subject with a history of severe allergy or bronchial asthma;
3. a clinically significant history of or current abnormality or disease of any organ system, including renal, hepatic, gastrointestinal, cardiovascular (except hyperlipidemia or controlled hypertension), pulmonary (including chronic asthma), endocrine (except diabetes), central nervous, or hematologic systems, or recent clinically significant surgery;
4. history of seizure, epilepsy, severe head injury, multiple sclerosis, or other known neurological conditions;
5. abnormal pre-admission vital signs, physical examination, clinical laboratory, or any safety variable which is considered clinically significant for this population by the Principal Investigator or Sponsor (or designee). Subjects with an abnormal serum creatinine should not be enrolled. Subjects with AST (SGOT), ALT (SGPT), GGT, alkaline phosphatase, bilirubin, blood urea nitrogen (BUN), prothrombin time (PT), or activated partial thromboplastin time (aPPT) >1.5 times above the upper limit of normal should not be enrolled;
6. any subject with a clinically significant mental or physical illness within 1 year prior to the first dose, including a history of alcohol and/or drug abuse within 1 year prior to the first dose of study medication;
7. Insulin requiring diabetics;
8. any subject who has received any known hepatic or renal clearance altering agents (eg, erythromycin, cimetidine, barbiturates, phenothiazines, St. John's Wort, etc.) within a period of 90 days prior to the first dose of study medication;
9. any subject who has received any approved prescription anti-obesity drug or has taken any over-the-counter medication for weight loss or who has received a thiazolidinedione or exanatide within a period of 90 days prior to the first dose of study medication;
10. ingestion or use of any investigational medication or device within 60 days prior to the first dose of study medication; ingestion or use of any investigational anti-obesity medication is prohibited within 3 months prior to the first dose of study medication;
11. any subject with history of malignancy in last 5 years, with exception of basal and squamous cell carcinomas of the skin;
12. any subject who is positive for HBsAG, Hepatitis C antibody, Hepatitis A IgM, or Human Immunodeficiency Virus (HIV) Viral Serology tests at the screening visit;
13. a positive qualitative urine drug or alcohol test at screening or at check-in;
14. mental capacity is limited to the extent that the subject cannot provide legal consent or understand information regarding the study;
15. any subject who has had a 10% weight loss in the past 3 months prior to the screening visit.

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years to 65 Years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: United States

Administrative Information

• NCT Number: NCT00806338
• Other Study ID Numbers: MSI-1436C-102
• Has Data Monitoring Committee: No
• U.S. FDA-regulated Product: Not Provided
• IPD Sharing Statement: Not Provided
• Responsible Party: Michael Gast, MD, PhD, Genaera Corporation
• Study Sponsor: Genaera Corporation
• Collaborators: Not Provided

Investigators

• Principal Investigator: Mark Kipnes, MD; dgd Research
• Principal Investigator: Gilbert Weiner, D.O. AOBFP; Cetero Research, San Antonio

• PRS Account: Genaera Corporation
• Verification Date: April 2009