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Safety Study Of Cetuximab Plus Dasatinib (BMS-354825) in Treating Advanced Solid Malignancies

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ClinicalTrials.gov Identifier: NCT00388427
Recruitment Status : Completed
First Posted : October 16, 2006
Last Update Posted : May 28, 2015
Sponsor:
Collaborator:
Bristol-Myers Squibb
Information provided by (Responsible Party):
Edward Chu, MD, University of Pittsburgh

Tracking Information
First Submitted Date  ICMJE October 13, 2006
First Posted Date  ICMJE October 16, 2006
Last Update Posted Date May 28, 2015
Study Start Date  ICMJE June 2007
Actual Primary Completion Date July 2009   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures  ICMJE
 (submitted: December 17, 2007)
To determine the toxicities and the maximum tolerated doses of dasatinib when combined with cetuximab for the treatment of advanced solid tumors [ Time Frame: Anticipated completion date December 2008 ]
Original Primary Outcome Measures  ICMJE
 (submitted: October 13, 2006)
To determine the toxicities and the maximum tolerated doses of dasatinib when combined with cetuximab for the treatment of advanced solid tumors
Change History
Current Secondary Outcome Measures  ICMJE
 (submitted: December 17, 2007)
  • To determine the objective response rate and overall survival in patients enrolled in the study [ Time Frame: Anticipated completion date December 2008 ]
  • To evaluate tissue biomarkers that relate to EGFR and Src signaling pathways on baseline tumor tissue and to study their modulation with cetuximab/dasatinib on post-treatment tumor tissue [ Time Frame: Anticipated completion date December 2008 ]
  • To measure Src in peripheral blood mononuclear cells (PBMCs) before and after therapy [ Time Frame: Anticipated completion date December 2008 ]
  • To evaluate EGFR gene copy number by FISH on baseline tumor tissue [ Time Frame: Anticipated completion date December 2008 ]
  • To determine pharmacokinetic parameters of dasatinib in patients with and without feeding tubes [ Time Frame: Anticipated completion date December 2008 ]
Original Secondary Outcome Measures  ICMJE
 (submitted: October 13, 2006)
  • To determine the objective response rate and overall survival in patients enrolled in the study
  • To evaluate tissue biomarkers that relate to EGFR and Src signaling pathways on baseline tumor tissue and to study their modulation with cetuximab/dasatinib on post-treatment tumor tissue
  • To measure Src in peripheral blood mononuclear cells (PBMCs) before and after therapy
  • To evaluate EGFR gene copy number by FISH on baseline tumor tissue
  • To determine pharmacokinetic parameters of dasatinib in patients with and without feeding tubes
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title  ICMJE Safety Study Of Cetuximab Plus Dasatinib (BMS-354825) in Treating Advanced Solid Malignancies
Official Title  ICMJE Phase I Study of Cetuximab Plus Dasatinib (BMS-354825) in Advanced Solid Malignancies
Brief Summary This is an open-label, safety study of cetuximab and differing dose levels of dasatinib in adult patients with advanced solid malignancies. Cetuximab will be administered as an intravenous infusion weekly. Dasatinib will be taken orally, once a day, on a continuous schedule at differing dose levels. The primary objective of this study is to determine the toxicities and the maximum tolerated doses of dasatinib when combined with cetuximab for the treatment of advanced solid tumors.
Detailed Description This is an open-label, phase I study of cetuximab and differing dose levels of dasatinib in adult patients with advanced solid malignancies. Cetuximab will be administered as an intravenous infusion on a standard dose and schedule (weekly, with the first dose at 400 mg/m2 and all subsequent weekly doses at 250 mg/m2). Dasatinib will be administered orally on a continuous schedule at the following dose levels: 100 mg QD (once a day), 150 mg QD, and 200 mg QD. Three to six patients will be enrolled at each dose level, and the final recommended phase II cohort will be expanded to include up to 12 additional patients. The doses will be escalated in successive cohorts of patients. On cycle 1, dasatinib administration will start one day prior to cetuximab administration. One cycle will be defined as 21 days, and cycles will continue until progression of disease or intolerable toxicities occur. Peripheral blood samples and pharmacokinetic blood samples will be taken on days 0, 1, 15, and 16 of Cycle 1 only. In patients with accessible tumor that give consent, patients will undergo a baseline tumor biopsy and a repeat biopsy after 14-21 days of the first cycle.
Study Type  ICMJE Interventional
Study Phase  ICMJE Phase 1
Study Design  ICMJE Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Condition  ICMJE Malignant Solid Tumour
Intervention  ICMJE
  • Drug: Dasatinib (BMS-354825)
    100 mg, 150 mg, or 200 mg per dose escalation schedule; continuous oral dosing on Days 1-21 of each 21-day cycle until progression or unacceptable toxicity develops.
  • Drug: Cetuximab (Erbitux, C225)
    Loading dose of IV 400 mg/m^2 on Day 1 of Cycle 1; IV 250 mg/m^2 weekly thereafter each 21-day cycle until progression or unacceptable toxicity develops.
Study Arms  ICMJE Advanced Solid Malignancies
Interventions:
  • Drug: Dasatinib (BMS-354825)
  • Drug: Cetuximab (Erbitux, C225)
Publications * Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status  ICMJE Completed
Actual Enrollment  ICMJE
 (submitted: January 21, 2014)
31
Original Enrollment  ICMJE
 (submitted: October 13, 2006)
30
Actual Study Completion Date  ICMJE February 2013
Actual Primary Completion Date July 2009   (Final data collection date for primary outcome measure)
Eligibility Criteria  ICMJE

Inclusion Criteria:

  1. Histologically or cytologically confirmed solid malignancy which is recurrent or metastatic or resistant to therapy. Patients w/plan of surgery for recurrent disease post cetuximab/dasatinib are eligible providing that they receive at least 2 cycles of therapy and provide baseline and post-treatment tumor tissue for correlatives.
  2. Any number of prior regimens but no prior EGFR or src inhibitors.
  3. Age greater or equal to 18 years.
  4. ECOG performance status less than or equal to 2 (Karnofsky greater than or equal to 60%).
  5. Life expectancy greater than 12 weeks.
  6. Patients must have normal organ and marrow function:

    • leukocytes greater than or equal to 3,000/mcL
    • absolute neutrophil count greater than or equal to 1,500/mcL
    • platelets greater than or equal to 100,000/mcL
    • total bilirubin within normal institutional limits
    • AST(SGOT)/ALT(SGPT) less than or equal to 2.5 X institutional upper limit of normal
    • creatinine up to 1.5 x normal institutional limits
  7. Ability to understand and the willingness to sign a written informed Consent document.
  8. No concomitant medication that are CYP3A4 inducers or potent inhibitors and should not take proton pump inhibitors and H2 antagonists in the first cycle of therapy and should try to avoid taking proton pump inhibitors and H2 antagonists during rest of treatment period.
  9. Sexually active women of childbearing potential must use an effective method of birth control during the course of the study, in a manner such that risk of failure is minimized. All WOCBP must have a negative pregnancy test prior to first receiving investigational product.

Exclusion Criteria:

  1. Chemotherapy or radiotherapy within 3 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
  2. Any other concurrent investigational agents.
  3. Patients w/ untreated brain metastases. However, patients who have stable brain disease (should be off corticosteroids) at least 4 weeks after completion of appropriate therapy are eligible.
  4. History of allergic reaction to monoclonal antibodies.
  5. Inability to swallow oral medications unless patients use a feeding tube.
  6. Uncontrolled angina or hypertension or any history of clinically significant ventricular arrhythmias (such as ventricular tachycardia, ventricular fibrillation, or Torsades de pointes).
  7. Prolonged QTc interval on pre-entry electrocardiogram (greater than 450 msec) on both the Fridericia and Bazett's correction.
  8. Diagnosed or suspected congenital long QT syndrome.
  9. Patients currently taking drugs that are generally accepted to have a risk of causing Torsades de Pointes including: quinidine, procainamide, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, erythromycins, clarithromycin, chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide, cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine.
  10. Any other uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, or psychiatric illness/social situations that would limit compliance with study requirements.
  11. History of significant bleeding disorder unrelated to cancer, including: diagnosed congenital bleeding disorders (e.g., von Willebrand's disease), diagnosed acquired bleeding disorder within one year (e.g., acquired anti-factor VIII antibodies).
  12. HIV-positive patients receiving combination antiretroviral therapy.
Sex/Gender  ICMJE
Sexes Eligible for Study: All
Ages  ICMJE 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers  ICMJE No
Contacts  ICMJE Contact information is only displayed when the study is recruiting subjects
Listed Location Countries  ICMJE United States
Removed Location Countries  
 
Administrative Information
NCT Number  ICMJE NCT00388427
Other Study ID Numbers  ICMJE 06-038
CA180049 ( Other Identifier: BMS )
Has Data Monitoring Committee Yes
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement  ICMJE Not Provided
Responsible Party Edward Chu, MD, University of Pittsburgh
Study Sponsor  ICMJE University of Pittsburgh
Collaborators  ICMJE Bristol-Myers Squibb
Investigators  ICMJE
Principal Investigator: Edward Chu, MD University of Pittsburgh
PRS Account University of Pittsburgh
Verification Date January 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP