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Genetics of Alpha Thalassemia in Israeli Ethnic Groups

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00159029
Recruitment Status : Completed
First Posted : September 12, 2005
Last Update Posted : August 10, 2017
Sponsor:
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization

Tracking Information
First Submitted Date September 9, 2005
First Posted Date September 12, 2005
Last Update Posted Date August 10, 2017
Actual Study Start Date April 1, 2004
Actual Primary Completion Date July 1, 2017   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Genetics of Alpha Thalassemia in Israeli Ethnic Groups
Official Title Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups
Brief Summary

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
Detailed Description

Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.

We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
Study Type Observational
Study Design Observational Model: Other
Time Perspective: Other
Target Follow-Up Duration Not Provided
Biospecimen Retention:   Samples With DNA
Description:
DNA isolated from peripheral blood.
Sampling Method Non-Probability Sample
Study Population Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.
Condition Alpha Thalassemia
Intervention Not Provided
Study Groups/Cohorts Not Provided
Publications * Rund D, Filon D, Jackson N, Asher N, Oron-Karni V, Sacha T, Czekalska S, Oppenheim A. An unexpectedly high frequency of heterozygosity for alpha-thalassemia in Ashkenazi Jews. Blood Cells Mol Dis. 2004 Jul-Aug;33(1):1-3. doi: 10.1016/j.bcmd.2004.04.009.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: March 2, 2006)		 100
Original Enrollment Not Provided
Actual Study Completion Date July 1, 2017
Actual Primary Completion Date July 1, 2017   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • diagnosis of deletional alpha thalassemia

Exclusion Criteria:

  • under age 18
Sex/Gender
Sexes Eligible for Study: All
Ages 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries Israel
Removed Location Countries  
 
Administrative Information
NCT Number NCT00159029
Other Study ID Numbers 152910-HMO-CTIL
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Current Responsible Party Deborah Rund, Hadassah Medical Organization
Original Responsible Party Not Provided
Current Study Sponsor Deborah Rund
Original Study Sponsor Hadassah Medical Organization
Collaborators Not Provided
Investigators
Principal Investigator: Deborah Rund, MD Hadassah Medical Organization
PRS Account Hadassah Medical Organization
Verification Date August 2017