Phase 2 Study of VELCADE Alone or VELCADE® Plus Docetaxel in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

• ClinicalTrials.gov Identifier: NCT00051974
• Recruitment Status: Completed
• First Posted: January 22, 2003
• Last Update Posted: February 11, 2008
• Sponsor: Millennium Pharmaceuticals, Inc.
• Information provided by: Millennium Pharmaceuticals, Inc.

Tracking Information

• First Submitted Date: January 21, 2003
• First Posted Date: January 22, 2003
• Last Update Posted Date: February 11, 2008
• Study Start Date: December 2002
• Actual Primary Completion Date: September 2004 (Final data collection date for primary outcome measure)
• Current Primary Outcome Measures: Not Provided
• Original Primary Outcome Measures: Not Provided
• Current Secondary Outcome Measures: Not Provided
• Original Secondary Outcome Measures: Not Provided
• Current Other Pre-specified Outcome Measures: Not Provided
• Original Other Pre-specified Outcome Measures: Not Provided

Descriptive Information

• Brief Title: Phase 2 Study of VELCADE Alone or VELCADE® Plus Docetaxel in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer
• Official Title: A Randomized, Multicenter, Open-Label, Phase 2 Study of VELCADE Alone or VELCADE Plus Docetaxel in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer
• Brief Summary: The purpose of this study is to evaluate how tumors in patients with non-small cell lung cancer respond to treatment with VELCADE alone versus VELCADE given with docetaxel and also to see what effects (good and bad) it has on you and your cancer.
• Detailed Description: In this study, patients with non-small cell lung cancer that is no longer responding to standard medical treatment with another anti-cancer drug will be randomly chosen to receive treatment with VELCADE alone or VELCADE in combination with docetaxel. Patients have almost equal chance of getting into either of the two treatment arms listed above.
• Study Type: Interventional
• Study Phase: Phase 2
• Study Design: Allocation: Randomized; Intervention Model: Parallel Assignment; Masking: None (Open Label); Primary Purpose: Treatment
• Condition: Non-Small Cell Lung Cancer
• Intervention: Drug: VELCADE™ (bortezomib) for Injection (formerly PS-341)
• Study Arms: Not Provided
• Publications *: Not Provided

Recruitment Information

• Recruitment Status: Completed
• Enrollment (submitted: June 23, 2005): 155
• Original Enrollment: Same as current
• Study Completion Date: Not Provided
• Actual Primary Completion Date: September 2004 (Final data collection date for primary outcome measure)

Eligibility Criteria

Inclusion Criteria

• Inoperable, locally advanced (Stage IIIB) or metastatic (Stage IV) NSCLC that has been histologically or cytologically confirmed.
• No more than 1 prior chemotherapy regimen.
• 18 years of age or older.
• Measurable or evaluable disease.
• KPS ≥70%.
• Life expectancy greater than 3 months.
• Female patient is either post-menopausal, surgically sterilized, or willing to use an acceptable method of birth control for the duration of the study.
• Male patient agrees to use an acceptable method of birth control for the duration of the study.
• Provide written informed consent before any study-related procedure not part of normal medical care is conducted.
• Willing and able to comply with the protocol requirements.

Exclusion Criteria

• Peripheral neuropathy of Grade 2 or greater intensity, as defined by the NCI Common Toxicity Criteria (CTC):

  • Grade 2: Objective sensory loss or paresthesia (including tingling), interfering with function, but not interfering with activities of daily living (ADLs).
  • Grade 3: Sensory loss or paresthesia interfering with ADLs.
  • Grade 4: Permanent sensory loss that interferes with function.
• Previous treatment with VELCADE.
• Previous treatment with docetaxel (prior treatment with paclitaxel will be allowed).
• Chemotherapy within 4 weeks prior to enrollment.
• Radiation therapy within 4 weeks prior to enrollment.
• Monoclonal antibodies within 6 weeks prior to enrollment.
• Any major surgery within 4 weeks prior to enrollment.

• Inadequate organ function at the Screening visit as defined by the following laboratory values:

  • Platelet count ≤100,000 x 109/L
  • Hemoglobin ≤8.0 g/dL
  • Absolute neutrophil count (ANC) ≤1.5 x 109/L
  • Aspartate transaminase (AST) ≥3 x the upper limit of the normal range (ULN)
  • Alanine transaminase (ALT) ≥3 times ULN
  • Creatinine ≥1.8 mg/dL
  • Total bilirubin ≥2 times ULN
• Myocardial infarction within 6 months prior to enrollment or has New York Hospital Association (NYHA) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant.
• No history of brain metastases or central nervous system disease.
• Active systemic infection requiring treatment.
• Treatment for a cancer other than NSCLC within 5 years prior to enrollment, with the exception of basal cell carcinoma or cervical cancer in situ.
• History of allergic reaction attributable to compounds containing boron or mannitol.
• Known to be human immunodeficiency virus (HIV)-positive. Patients assessed by the investigator to be at risk for HIV infection should be tested in accordance with local regulations.
• Known to be hepatitis B surface antigen-positive or has known active hepatitis C infection. Patients assessed by the investigator to be at risk for hepatitis B or C infection should be tested in accordance with local regulations.
• Poorly controlled hypertension, diabetes mellitus, or another serious medical or psychiatric illness that could, in the investigator's opinion, potentially interfere with the completion of treatment according to this protocol.
• Pregnant or breast-feeding female patient. Confirmation that the patient is not pregnant must be established by a negative serum β-human chorionic gonadotropin (β-hCG) pregnancy test result obtained during the Screening period. Pregnancy testing is not required for post-menopausal or surgically sterilized women.
• Currently enrolled in another clinical research study or has received an investigational agent for any reason within 4 weeks of enrollment.

Sex/Gender

• Sexes Eligible for Study: All

• Ages: 18 Years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Contacts: Contact information is only displayed when the study is recruiting subjects
• Listed Location Countries: United States

Administrative Information

• NCT Number: NCT00051974
• Other Study ID Numbers: M34102-048
• Has Data Monitoring Committee: Not Provided
• U.S. FDA-regulated Product: Not Provided
• IPD Sharing Statement: Not Provided
• Responsible Party: Not Provided
• Study Sponsor: Millennium Pharmaceuticals, Inc.
• Collaborators: Not Provided
• Investigators: Not Provided
• PRS Account: Millennium Pharmaceuticals, Inc.
• Verification Date: February 2008