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Trial record 2 of 84 for:    Taste Disorders AND sense

Study of Taste Deficits

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ClinicalTrials.gov Identifier: NCT00022997
Recruitment Status : Completed
First Posted : August 20, 2001
Last Update Posted : June 6, 2019
Sponsor:
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Deafness and Other Communication Disorders (NIDCD) )

Tracking Information
First Submitted Date August 17, 2001
First Posted Date August 20, 2001
Last Update Posted Date June 6, 2019
Study Start Date August 16, 2001
Primary Completion Date Not Provided
Current Primary Outcome Measures Not Provided
Original Primary Outcome Measures Not Provided
Change History Complete list of historical versions of study NCT00022997 on ClinicalTrials.gov Archive Site
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Study of Taste Deficits
Official Title Studies of Deficits in the Sense of Taste
Brief Summary

This study will explore the genetics of taste and taste deficits. The sense of taste plays a crucial role in food choices, allowing people to identify beneficial foods (those with high caloric value, which are typically sweet) and foods likely to be toxic (usually bitter substances). The loss of sense of taste in older people plays a role in decreased appetite and poor nutrition. Taste deficits may adversely affect people in ways that are not well understood. This study will examine why some people (about one-fourth of all people in the United States) cannot taste a substance called phenylthiocarbamide (PTC). The inability to taste PTC is due to inherited factors that are not yet clear.

Individuals age 18 and older who can taste PTC and individuals who cannot taste PTC may be eligible for this study. Participants will taste a number of liquid solutions until they find one with a clear taste. Then they will taste another group of solutions and decide which ones have that taste and which have no taste. Finally, they will taste a third group of solutions until they find one with a different taste. About 2 tablespoons of blood will be drawn from participants for genetic tests related to the sense of taste.

Detailed Description The primary goal of this study is to identify the underlying cause of deficits in the ability to taste different commonly consumed substances, including the bitter compound phenylthiocarbamide (PTC) as a model. Individuals will be tested to identify those who can and cannot taste PTC, as well as for their ability to taste a variety of sweet, sour, salty, and savory substances. Individuals will have 20 cc of blood drawn to obtain DNA. These DNA samples will then be analyzed for variation in genes whose products are known to be involved in taste perception pathways. Information about individuals DNA sequence variation will then be correlated with their taste phenotype to identify the specific genetic variation that causes phenotypic variation, providing molecular structure-function information in taste sensory pathways.
Study Type Observational
Study Design Not Provided
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Not Provided
Study Population Not Provided
Condition
  • Taste Disorder
  • Healthy
Intervention Not Provided
Study Groups/Cohorts Not Provided
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Completed
Actual Enrollment
 (submitted: September 26, 2017)
450
Original Enrollment
 (submitted: June 23, 2005)
400
Study Completion Date June 4, 2019
Primary Completion Date Not Provided
Eligibility Criteria
  • INCLUSION CRITERIA:
  • Individuals age 18 years and older.
  • Subjects must be medically healthy, with no cognitive impairment or physical swallowing inability or impairment
  • Must be able to provide informed consent
  • Must be able to read and understand English.
  • NIH employees or staff may participate in this study if they meet the eligibility criteria.

EXCLUSION CRITERIA:

  • Cannot be younger than 18 years of age
  • Subjects with suspected or known cognitive impairment or physical swallowing inability or impairment
  • Subjects who are unable to provide informed consent
  • Subjects who are taking any pyschoactive medications or medications that affect their nervous system, such as antidepressants or anti-psychotics.
  • Subjects who have known problems with these sense of taste
  • Subjects who are currently using tobacco
Sex/Gender
Sexes Eligible for Study: All
Ages 18 Years and older   (Adult, Older Adult)
Accepts Healthy Volunteers No
Contacts Contact information is only displayed when the study is recruiting subjects
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT00022997
Other Study ID Numbers 010230
01-DC-0230
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party National Institutes of Health Clinical Center (CC) ( National Institute on Deafness and Other Communication Disorders (NIDCD) )
Study Sponsor National Institute on Deafness and Other Communication Disorders (NIDCD)
Collaborators Not Provided
Investigators
Principal Investigator: Dennis T Drayna, Ph.D. National Institute on Deafness and Other Communication Disorders (NIDCD)
PRS Account National Institutes of Health Clinical Center (CC)
Verification Date June 4, 2019