A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy
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|ClinicalTrials.gov Identifier: NCT00001573|
Recruitment Status : Completed
First Posted : December 10, 2002
Last Update Posted : March 4, 2008
|First Submitted Date ICMJE||November 3, 1999|
|First Posted Date ICMJE||December 10, 2002|
|Last Update Posted Date||March 4, 2008|
|Study Start Date ICMJE||March 1997|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures ICMJE||Not Provided|
|Original Primary Outcome Measures ICMJE||Not Provided|
|Change History||Complete list of historical versions of study NCT00001573 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE||Not Provided|
|Original Secondary Outcome Measures ICMJE||Not Provided|
|Current Other Outcome Measures ICMJE||Not Provided|
|Original Other Outcome Measures ICMJE||Not Provided|
|Brief Title ICMJE||A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy|
|Official Title ICMJE||A Phase I Study of SU101 in Pediatric Patients With Refractory Malignancy|
A dose escalation scale consisting of 5 dosage levels is being used to determine the maximum tolerated dose (MTD) of SU101. A minimum of 3 and a maximum of 6 patients will be enrolled at each dose level. MTD is defined as the dose level immediately below that at which 2 or more patients exhibit dose limiting toxicity.
Each treatment cycle is 21 days. Patients receive a 96 hour continuous IV infusion of SU101 on days 1-4.
|Detailed Description||SU101 is a member of a novel class of antineoplastic agents, platelet-derived growth factor (PDGF) receptor inhibitors. Preclinical data suggests that SU101 might be an effective agent against neuroglial tumors as well as a variety of sarcomas. A pediatric phase I trial of SU101 in children with these malignancies will be conducted to find the maximum tolerated dose of SU101 and define the toxicity profile of this agent. In addition, we will define the pharmacokinetics of SU101 and its active metabolite SU0020 in pediatric patients and gather preliminary information regarding response.|
|Study Type ICMJE||Interventional|
|Study Phase||Phase 1|
|Study Design ICMJE||Primary Purpose: Treatment|
|Intervention ICMJE||Drug: SU101|
|Study Arms||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Completed|
|Original Enrollment ICMJE||Same as current|
|Study Completion Date||May 2000|
|Primary Completion Date||Not Provided|
|Eligibility Criteria ICMJE||
Histologically proven primary CNS malignancy, neuroblastoma or sarcoma that is refractory to standard therapy or for which no standard therapy exists and disease can not be cured by surgery.
Recovered from toxic affects of all prior therapy.
No investigational agent within past 2 weeks.
BIOLOGY THERAPY: Not specified.
No myelosuppressive therapy within past 3 weeks.
No nitrosourea within past 6 weeks.
ENDOCRINE THERAPY: If receiving dexamethasone dose must be stable for at least 2 weeks.
RADIOTHERAPY: Not specified.
SURGERY: Not specified.
Age: 3 to 21.
Performance status: ECOG 0-2.
Life expectancy: At least 8 weeks.
AGC greater than 1500/mm(3).
Hemoglobin greater than or equal to 8.0 g/dL percent.
Platelet count greater than 100,000/mm(3).
For patients with bone marrow involvement or history of bone marrow transplantation or craniospinal radiotherapy: AGC greater than 750/mm(3), Hemoglobin greater than 6.0 g/dL, Platelet count greater than 50,000/mm(3).
SGOT, SGPT or alkaline phosphatase less than 3 times upper limit of normal.
Bilirubin no less than or equal to 1.5 times upper limit of normal.
Ages 3-5 Creatinine no greater than 0.8 mg/dL.
Ages 5-10 Creatinine no greater than 1.0 mg/dL.
Ages 10-15 Creatinine no greater than 1.2 mg/dL.
Ages 16-21 Creatinine no greater than 1.5 mg/dL.
All patients or their legal guardians (if the patient is under 18 years old) must sign a document of informed consent indicating their understanding of the investigational nature and the risks of this study.
For patients with brain tumors who are over 18 years of age, a DPA should be signed.
Not pregnant or nursing.
Not allergic to etoposide.
No acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risks associated with study participation/study drug administration or may interfere with the interpretation of study results.
|Ages||Child, Adult, Older Adult|
|Accepts Healthy Volunteers||No|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries ICMJE||United States|
|Removed Location Countries|
|NCT Number ICMJE||NCT00001573|
|Other Study ID Numbers ICMJE||970087
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Not Provided|
|Study Sponsor ICMJE||National Cancer Institute (NCI)|
|Collaborators ICMJE||Not Provided|
|Investigators ICMJE||Not Provided|
|PRS Account||National Institutes of Health Clinical Center (CC)|
|Verification Date||February 2000|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP