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Social Support and Enhanced Fear Extinction

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ClinicalTrials.gov Identifier: NCT04565041
Recruitment Status : Not yet recruiting
First Posted : September 25, 2020
Last Update Posted : September 25, 2020
Sponsor:
Collaborator:
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Naomi Eisenberger, University of California, Los Angeles

Brief Summary:

University of California, Los Angeles researchers will recruit healthy participants and anxious participants (those diagnosed with social anxiety disorder) age 18-55 years old to participate in a study examining whether the ability of social support figure reminders to enhance the extinction of fear in healthy participants extends to those with anxiety disorders.

After being recruited from the UCLA community (healthy participants, n = 50) or referred by treatment providers at the Anxiety and Depression Research Center at UCLA (anxious participants, n = 50) and undergoing a telephone screening and in-person screening, 100 participants will be enrolled in the study. During the experiment, all participants will undergo the same procedures: undergoing a fear extinction procedure in which threatening cues--cues that predict electric shock--will be paired with either an image of a social support figure (provided by participants) or an image of a smiling stranger. These pairings will be presented repeatedly in the absence of shock in order for fear extinction to occur. Participants will return for a follow-up test to determine if fear extinction was successful.


Condition or disease Intervention/treatment Phase
Fear Anxiety Behavioral: Social Support Not Applicable

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 100 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Can Social Support Figures Enhance Fear Extinction in Patients With Social Anxiety?
Estimated Study Start Date : January 2022
Estimated Primary Completion Date : December 2022
Estimated Study Completion Date : December 2022

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Anxiety

Arm Intervention/treatment
Experimental: Social Support Behavioral: Social Support
Presence of an image of a social support figure (provided by participant) during a fear extinction procedure




Primary Outcome Measures :
  1. Fear response directly post-extinction [ Time Frame: within experimental session - directly post-extinction procedure ]
    presence of fear response as indicated by significantly higher galvanic skin response (GSR: an index of peripheral stress responding) to a previously learned fearful image (CS+) compared to a baseline comparator (CS-: never learned to be fearful).

  2. Fear response 24 hours post-extinction [ Time Frame: 24 hours following the completion of fear extinction procedures ]
    presence of fear response as indicated by significantly higher galvanic skin response (GSR: an index of peripheral stress responding) to a previously learned fearful image (CS+) compared to a baseline comparator (CS-: never learned to be fearful).



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy adults 18 and 35
  • fluent in English
  • no history of mental illness (healthy participants: including anxiety, depression, phobia, or any other mental health related disorder diagnosed by a mental health professional)
  • diagnosis of social anxiety disorder (anxious participants: allowed co-morbid disorders include depression, other anxiety disorders, and PTSD)

Exclusion Criteria:

  • pregnant or planning to become pregnant during the experiment period
  • presence of chronic mental illness (healthy participants: as determined by the report of a past diagnosis of mental illness by a physician or psychologist and/or the prescription of medication related to mental health disorder; including anxiety, depression, phobia, or any other diagnosed psychological disorder)
  • presence of non-allowed co-morbid disorders (anxious participants: including, bipolar disorder, psychosis, substance use disorder, neurological disorder, and/or obsessive-compulsive disorder)
  • current and regular use of prescription medications related to mental health disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04565041


Contacts
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Contact: Erica Hornstein, PhD 9175664470 ericahornstien@ucla.edu
Contact: Naomi Eisenberger, PhD

Locations
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United States, California
UCLA Department of Psychology
Los Angeles, California, United States, 90095-1563
Sponsors and Collaborators
University of California, Los Angeles
National Institute of Mental Health (NIMH)
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Responsible Party: Naomi Eisenberger, Professor, University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT04565041    
Other Study ID Numbers: SSE
First Posted: September 25, 2020    Key Record Dates
Last Update Posted: September 25, 2020
Last Verified: September 2020

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Naomi Eisenberger, University of California, Los Angeles:
social support
fear extinction
Additional relevant MeSH terms:
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Anxiety Disorders
Mental Disorders