Bleb Vascularity and the Outcomes After Trabeculectomy
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Study objective: To evaluate the relationship between filtering bleb vascularity and the surgical outcomes after trabeculectomy
Study design: A prospective study of 51 eyes of 44 patients after primary MMC-augmented trabeculectomy. The follow-up was 12 months.
Condition or disease
Total vessel area of a filtering bleb was measured with ImageJ software on colour photographs of a filtering bleb on day 1, 14, 1, 3 and 6 months and 1 year after trabeculectomy. Blebs were classified clinically as successful (IOP below 18 mmHg and a >30% reduction in IOP without antiglaucoma medications or additional surgical interventions) or failed. Linear regression analysis was performed to determine the correlation of the bleb vascularity with IOP.
The successful bleb group consisted of eyes with IOP below 18 mmHg and a >30% reduction in IOP at 1 year after surgery without antiglaucoma medications or additional surgical interventions. Failed blebs were defined when IOP was over 18 mmHg, below 18 mmHg with antiglaucoma medications or if any additional surgical intervention was necessary
Secondary Outcome Measures :
Correlation of Bleb vascularity with IOP [ Time Frame: 6 months ]
Linear regression analysis was performed to determine the correlation of the bleb vascularity with IOP
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Layout table for eligibility information
Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
patients with medically uncontrolled glaucoma who underwent primary trabeculectomy with mitomycin C (MMC) in the Department of Diagnostics and Microsurgery of Glaucoma of Medical University of Lublin, Poland
primary open angle glaucoma (POAG) with medically uncontrolled intraocular pressure (IOP)
pseudoexfoliation glaucoma (PEXG) with medically uncontrolled intraocular pressure (IOP)
primary angle closure glaucoma (PACG)
secondary glaucoma except PEXG
previous eye surgery
subjects with decreased vision due to other reasons than glaucoma (e.g., exudative age-related macular degeneration (AMD), proliferative diabetic retinopathy, inflammatory eye diseases)