Double-blind Study to Evaluate the Safety and Efficacy of Antroquinonol in Mild-Moderate COVID-19 Hospitalized Patients
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT04523181|
Recruitment Status : Completed
First Posted : August 21, 2020
Last Update Posted : January 6, 2022
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|Condition or disease||Intervention/treatment||Phase|
|Covid-19||Drug: Antroquinonol Other: Placebo||Phase 2|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||124 participants|
|Intervention Model:||Parallel Assignment|
|Intervention Model Description:||A Phase 2 Randomized, Double blind, Placebo Controlled, Proof of Concept Study to Evaluate the Safety and Efficacy of Antroquinonol in Hospitalized Patients with Mild to Moderate Pneumonia due to COVID 19|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Masking Description:||Double blind, Placebo Controlled|
|Official Title:||A Phase 2 Randomized, Double-blind, Placebo-controlled, Proof of Concept Study to Evaluate the Safety and Efficacy of Antroquinonol in Hospitalized Patients With Mild to Moderate Pneumonia Due to COVID-19|
|Actual Study Start Date :||October 8, 2020|
|Actual Primary Completion Date :||December 23, 2021|
|Actual Study Completion Date :||December 23, 2021|
Active Comparator: Antroquinonol with SOC
Antroquinonol in a dose of 100 mg (1 capsule) administered twice daily (BID) orally, for 14 days.
double-blind for antroquinonol and Placebo with same out-look and same frequency.
Other Name: Hocena
Placebo Comparator: Placebo with SOC
placebo (1 capsule) administered twice daily (BID) orally, for 14 days.
Capsule without active compound
- recover ratio [ Time Frame: 14 day ]The proportion of patients who are alive and free of respiratory failure (e.g., no need for invasive mechanical ventilation, non invasive ventilation, high flow oxygen, or ECMO) on Day 14
- Time to 2-point improvement [ Time Frame: 28 day ]Clinical change score as measured by the WHO COVID-19 Clinical Improvement Ordinal Scale
- Duration of hospitalization [ Time Frame: 28 day ]time for patient discharge
- Time to virological clearance [ Time Frame: 28 day ]measured as study days from start of treatment to first negative SARS CoV 2 PCR test
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:||18 Years to 80 Years (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||No|
- Willing and able to provide informed consent.
- Male or female patients between 18 and 80 years of age.
- Oxygen Saturation <94% in room air at screening.
Hospitalized with mild COVID 19 disease (not requiring oxygen therapy [WHO COVID-19 Clinical Improvement Ordinal Scale, score of 3] or requiring oxygen therapy by mask or nasal prong [WHO COVID-19 Clinical Improvement Ordinal Scale, score of 4]). Requirement of oxygen therapy by mask with reservoir to treat severe COVID 19 pneumonia is not allowed for enrollment.
Note: Hospitalized patients can also include patients admitted to centers conditioned as hospitals to treat COVID-19 patients.
- Chest x ray or computerized tomography (CT) scan consistent with pneumonia.
- Onset of COVID-19 symptoms within 2 weeks prior to randomization.
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV 2) infection confirmed by a polymerase chain reaction (PCR) test, antigen, or any authorized commercial or public health assay (nasopharyngeal, oropharyngeal, or respiratory samples, not serology testing).
- Male patients and female patients of childbearing potential must agree to use protocol-specified methods of contraception.
- Female patients of childbearing potential must have a negative pregnancy test at Screening or pretreatment on Day 1.
- Male patients must agree not to donate sperm from the first dose through 90 days after the last dose of study treatment; female patients of childbearing potential should refrain from donation of ova from Day 1 until 90 days after the last dose of study treatment.
- Patient is, in the opinion of the investigator, willing and able to comply with the study treatment regimen and all other study requirements.
- Female patient is pregnant or breastfeeding.
- Any patient's concomitant life threatening condition, including but not limited to: requiring mechanical ventilation, acute respiratory distress syndrome, shock, or cardiac failure.
- Evidence of multi lobar consolidation pneumonia or cavities on chest x ray or CT scan.
- Severe COVID 19 disease as defined by the WHO COVID-19 Clinical Improvement Ordinal Scale, scores of 5 (non invasive ventilation or high flow oxygen), 6 (intubation and mechanical ventilation), or 7 (ventilation + additional organ support pressors, renal replacement therapy, ECMO).
- Medical history significant for the following pulmonary diseases: lung cancer, cystic fibrosis, empyema.
- Respiratory rate >30 respirations per minute.
- History of abuse of drugs or alcohol that could interfere with adherence to study requirements, as judged by the investigator.
- Treatment with other drugs thought to possibly have activity against COVID 19 within 7 days prior to enrollment or concurrently. Note: remdesivir or other authorized treatments for COVID 19 is allowed if considered SoC, if started prior to randomization or during the study.
- Use of Antrodia camphorata -containing products within 2 weeks prior to the first administration of study drug.
- Use of other investigational drugs within 30 days of dosing, or plans to enroll in another clinical trial of an investigational agent while participating in the present study. Note: authorized COVID 19 vaccines are not considered investigational and are not exclusionary.
- Clinically significant abnormal electrocardiogram (ECG) at Screening, as determined by the investigator.
- Patient requires frequent or prolonged use of systemic corticosteroids (≥20 mg of prednisone/day or equivalent for >4 weeks) or other immunosuppressive drugs (eg, for organ transplantation or autoimmune conditions).
Abnormal laboratory values at Screening:
- Estimated glomerular filtration rate <50 mL/min.
- Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >5 × upper limit of normal (ULN), or ALT/AST >3 × ULN plus total bilirubin >2 × ULN.
- Total bilirubin >1.5 × ULN, unless the patient has known Gilbert's syndrome.
- Hemoglobin <9 g/dL for females or <11 g/dL for males.
- Absolute neutrophil count <1,500/mm3.
- Thrombocytopenia (platelets count <100 × 109/L).
- Treatment with any antiviral drugs (except remdesivir or other authorized treatments for COVID 19), or with any drugs known to be strong inducers or inhibitors of cytochrome P450 isoform (CYP) 2C19, CYP3A4, CYP2C8, and CYP2E1 within 14 days or 5 half lives prior to the start of study treatment. Drugs with a narrow therapeutic index that are substrates of 1A2, 2B6, 2C8, 2C9, 2C19, 3A, and 2D6 are also prohibited.
- Inability to swallow oral medications or a gastrointestinal disorder with diarrhea (eg, Crohn's disease), malabsorption, or diarrhea of any etiology at baseline.
- Any other clinically significant medical condition or laboratory abnormality that, in the opinion of the investigator, would jeopardize the safety of the patient or potentially impact patient compliance or the safety/efficacy observations in the study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04523181
|United States, Indiana|
|Franciscan Health Michigan City|
|Michigan City, Indiana, United States, 46360|
|United States, Kansas|
|Ascension.Via Christi Research|
|Wichita, Kansas, United States, 67214|
|United States, Maryland|
|Adventist Healthcare Shady Grove Medical Center|
|Rockville, Maryland, United States, 20850-3357|
|United States, New Jersey|
|South Jersey Infectious Disease|
|Somers Point, New Jersey, United States, 08244|
|United States, North Carolina|
|Duke University Southeastern Health|
|Lumberton, North Carolina, United States, 28358|
|Buenos Aires, Capital Federal, Argentina, C1094AAD|
|Clinica de los Virreyes|
|Buenos Aires, Capital Federal, Argentina, C1426AGU|
|Sanatorio Privado Mayo SA|
|Cordoba, Ciudad De Cordoba, Argentina, 5000|
|Cordoba, Cuidad De Cordoba, Argentina, 5000|
|Clinica Viedma SA|
|Viedma, Pcia De Rio Negro, Argentina, R8500|
|Clínica Internacional S.A. - Sede Lima|
|Lima Cercado, Lima, Peru, 15001|
|Unidad de Investigacion, Hospital Nacional IV Alberto Sabogal Sologuren-Essalud, Red Assitencial Sabogal|
|Callao, Peru, 07011|
|Hospital de Chancay|
|Chancay, Peru, 15131|
|Asociación Civil Selva Amazónica|
|Iquitos, Peru, 16001|
|Hospital III Daniel Alcides Carrion - EsSalud|
|Tacna, Peru, 23000|
|Responsible Party:||Golden Biotechnology Corporation|
|Other Study ID Numbers:||
|First Posted:||August 21, 2020 Key Record Dates|
|Last Update Posted:||January 6, 2022|
|Last Verified:||August 2021|
|Individual Participant Data (IPD) Sharing Statement:|
|Plan to Share IPD:||No|
|Studies a U.S. FDA-regulated Drug Product:||Yes|
|Studies a U.S. FDA-regulated Device Product:||No|
Respiratory Tract Infections
RNA Virus Infections
Respiratory Tract Diseases