Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection
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Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.
Condition or disease
Aortic DissectionFamily ResearchAortic Dissection, Familial, With or Without Aortic Aneurysm
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Layout table for eligibility information
Ages Eligible for Study:
Child, Adult, Older Adult
Sexes Eligible for Study:
Accepts Healthy Volunteers:
1, family members have no traumatic aortic dissection; 2, no pregnancy or tumor.
Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;
Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms