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Stress Test on the Prediction of Cardiovascular Events in a High-risk Firefighter Population (FIRE-PREV)

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ClinicalTrials.gov Identifier: NCT04423822
Recruitment Status : Not yet recruiting
First Posted : June 9, 2020
Last Update Posted : July 7, 2020
Sponsor:
Information provided by (Responsible Party):
Centre Hospitalier Universitaire de Saint Etienne

Brief Summary:
If the risk of myocardial infarction in activity is widely demonstrated to date for firefighters, and the realization of a stress test in those at high cardiovascular risk included in the practice habits, no study has evaluated the contributions and limits of the realization of a stress test in this specific population of firefighters at high cardiovascular risk for the prediction of cardiovascular events.

Condition or disease Intervention/treatment
High Cardiovascular Risk Firefighter Other: stress test

Detailed Description:
The professional practice of firefighting presents risks specific, especially cardiovascular. In the United States 30% of Firefighter deaths are the result of a myocardial infarction that occurred while on duty. Certain occupational tasks expose firefighters to a higher risk of myocardial infarction (high physical load, inhalation of products). There is no recommendation on how to assess cardiovascular risk in French firefighters. In the absence of consensus, the Loire Departmental Fire and Rescue Service has constructed a scale for collecting cardiovascular risk factors (expert working group) to identify firefighters at high cardiovascular risk. A maintenance visit (mandatory every two years until the age of 38 and then once a year) is the best way to assess this cardiovascular risk, with a biological assessment and an electrocardiogram after the age of 40. If cardiovascular risk factors are present and the cardiovascular risk is high, the resting electrocardiogram should be supplemented by an exercise test. An exercise test can directly or indirectly quantify the endurance capacities of firefighters and reveal cardiac abnormalities sometimes absent at rest. Half of all myocardial infarctions occur without any prior symptomatology and remain totally asymptomatic, discovered during routine examinations. If the risk of myocardial infarction in activity is widely demonstrated to date for firefighters, and the realization of a stress test in those at high cardiovascular risk included in the practice habits, no study has evaluated the contributions and limits of the realization of a stress test in this specific population of firefighters at high cardiovascular risk for the prediction of cardiovascular events.

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Study Type : Observational
Estimated Enrollment : 284 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Contributions and Limitations of the Stress Test on the Prediction of Cardiovascular Events in a High-risk Firefighter Population
Estimated Study Start Date : September 2020
Estimated Primary Completion Date : February 2021
Estimated Study Completion Date : February 2021

Group/Cohort Intervention/treatment
Firefighter
Firefighter with high cardiovascular risk
Other: stress test
endurance capacity




Primary Outcome Measures :
  1. Cardiovascular morbidity [ Time Frame: Between 2006 and 2014 ]
    determined by occurrence of: Cardiovascular death; Myocardial infarction; stroke; Arteriopathy; Atrial fibrillation

  2. Cardiovascular mortality [ Time Frame: Between 2006 and 2014 ]
    determined by occurrence of: Cardiovascular death; Myocardial infarction; stroke; Arteriopathy; Atrial fibrillation



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
firefighters with high cardiovascular risk
Criteria

Inclusion Criteria:

  • Any professional or volunteer firefighter with a high cardiovascular risk attached to the Departmental Fire and Rescue Service of the Loire who has carried out an effort test between 2006 and 2014.
  • Subject who received informed oral information about the study by telephone and agreed to participate in the study

Exclusion Criteria:

  • Subject unable to understand the study
  • Subject matter subject to a legal protection measure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04423822


Contacts
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Contact: David HUPIN, MD 04 77 82 92 72 ext +33 david.hupin@chu-st-etienne.fr
Contact: Marie PEURIERE, CRA 04 77 82 92 72 ext +33 marie.peuriere@chu-st-etienne.fr

Locations
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France
Centre Hospitalier Universitaire
Saint-Étienne, France
Principal Investigator: David HUPIN, MD         
Sub-Investigator: Angéliqe SAVAL, MD         
Sponsors and Collaborators
Centre Hospitalier Universitaire de Saint Etienne
Investigators
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Principal Investigator: David HUPIN, MD CHU SAINT-ETIENNE
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Responsible Party: Centre Hospitalier Universitaire de Saint Etienne
ClinicalTrials.gov Identifier: NCT04423822    
Other Study ID Numbers: 19CH235
2020-A00270-39 ( Other Identifier: ANSM )
First Posted: June 9, 2020    Key Record Dates
Last Update Posted: July 7, 2020
Last Verified: July 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:
firefighter
high cardiovascular risk
stress tests