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Egyptian Initial Experience About 2019 Novel Corona Virus: Study of 48 Patients in Alexandria-Egypt Using Chest CT

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04382469
Recruitment Status : Completed
First Posted : May 11, 2020
Last Update Posted : May 12, 2020
Sponsor:
Information provided by (Responsible Party):
Ahmed Samir, Alexandria University

Brief Summary:

Background: Corona virus disease 2019 (COVID-19) is a highly infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Purpose: To give initial experience about COVID-19 in Alexandria-Egypt describing radiological patterns of lung involvement, also surveying prevalence of co-morbid lung diseases and their effect on COVID-19 presentation.

Methods: Retrospective study including 48 patients with positive polymerase chain reaction (PCR) test for COVID-19 during the period from February 2020 till May 2020 in Alexandria/Egypt. Full clinical and laboratory data are obtained. High resolution computed tomography (HRCT) findings are described. Serial follow up studies are done. Surveying co-morbid lung diseases done including tuberculosis (TB), interstitial lung diseases (ILDs), chronic obstructive lung disease (COPD), immune and vascular-related diseases. Prevalence rate is the predominant analysis.


Condition or disease
COVID

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Study Type : Observational
Actual Enrollment : 48 participants
Observational Model: Case-Crossover
Time Perspective: Retrospective
Official Title: Egyptian Initial Experience About 2019 Novel Corona Virus Disease (COVID-19): Single-center Study Analysis of 48 Patients in Alexandria-Egypt Regarding Radiological Patterns and Co-morbid Lung Diseases
Actual Study Start Date : February 1, 2020
Actual Primary Completion Date : April 30, 2020
Actual Study Completion Date : May 1, 2020

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Radiological pattern of initial presentation, disease progress, healing and recovery [ Time Frame: "through study completion, an average of 1 month" ]
    HRCT findings

  2. Survey of co-morbid lung diseases [ Time Frame: "through study completion, an average of 1 month" ]
    prevalence



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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Sampling Method:   Probability Sample
Study Population
Primary care centers
Criteria

Inclusion Criteria:

  • Positive COVID-19

Exclusion Criteria:

  • Incomplete medical records, degrade CT images because of patient tachypnea and motions artifacts, also unremarkable CT scans.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04382469


Locations
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Egypt
Faculty of Medicine, University of Alexandria
Alexandria, Egypt, 21526
Sponsors and Collaborators
Alexandria University
Investigators
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Principal Investigator: Ahmed Samir, MD Department of Radio-diagnosis.
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Responsible Party: Ahmed Samir, Lecturer of radio-diagnosis, Alexandria University
ClinicalTrials.gov Identifier: NCT04382469    
Other Study ID Numbers: IRB (00012098), FWA (00018699)
First Posted: May 11, 2020    Key Record Dates
Last Update Posted: May 12, 2020
Last Verified: May 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: The investigators will recommend further large group future researches for some notices in the study, but preferably not be biased

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Coronavirus Infections
COVID-19
Coronaviridae Infections
Nidovirales Infections
RNA Virus Infections
Virus Diseases
Infections
Respiratory Tract Infections
Pneumonia, Viral
Pneumonia
Lung Diseases
Respiratory Tract Diseases