Diaphragm Ultrasound Measurements With Variations in Modes of Ventilation
|ClinicalTrials.gov Identifier: NCT04319939|
Recruitment Status : Recruiting
First Posted : March 24, 2020
Last Update Posted : March 24, 2020
|Condition or disease||Intervention/treatment|
|Mechanical Ventilation||Other: Assist Control Mode and Pressure Support Mode Mechanical Ventilation|
In this study diaphragm ultrasound measurements at end-expiration and peak inspiration phases in assist control and pressure support mode in consented patients admitted to the medical intensive care unit. One-time measurements will be obtained during the first 48hrs that the patients are receiving mechanical ventilation.
Three consecutive images will be obtained by an investigator that is blinded to the mode (controlled vs. spontaneous). Once measurements are obtained, a second investigator will switch to the other mode (controlled vs. spontaneous) and the blinded investigator will obtain three consecutive images after the patient has adjusted to the subsequent mode (one minute). Tidal volumes will be matched between modes as close as possible. The order of modes to ultrasound (controlled then spontaneous or spontaneous then controlled) will be determined by the non-blinded second investigator. Once the ultrasound measurements are obtained by the research team, image acquisition is concluded for the enrolled patient. The ventilator will be programmed back to the original settings determined by the medical ICU team.
The hypothesis is that the end-expiration diaphragm ultrasound measurement will be thicker in spontaneous mode than controlled mode.
|Study Type :||Observational|
|Estimated Enrollment :||66 participants|
|Official Title:||Diaphragm Ultrasound Measurements With Variations in Modes of Ventilation|
|Actual Study Start Date :||February 5, 2020|
|Estimated Primary Completion Date :||January 6, 2021|
|Estimated Study Completion Date :||January 6, 2021|
|Participants receiving mechanical ventilation||
Other: Assist Control Mode and Pressure Support Mode Mechanical Ventilation
Diaphragm ultrasound measurements (end expiration and peak inspiration thickness) will be performed in assist control mode and pressure support mode mechanical ventilation in each participant. The participant will thus serve as his/her own control for these interventions.
- End expiratory diaphragm thickness in controlled and spontaneous modes [ Time Frame: Less than 48 hours after mechanical ventilation ]Diaphragm ultrasound measurement at end expiration in assist control mode and pressure support mode
- Thickening fraction in controlled and spontaneous modes [ Time Frame: Less than 48 hours after mechanical ventilation ]Diaphragm ultrasound measurement at end expiration and inspiration to calculate thickening fraction = (peak inspiration thickness - end expiration thickness)/end expiration thickness in assist control and pressure support mode ventilation
- Variance in peak inspiration thickness in controlled and spontaneous modes [ Time Frame: Less than 48 hours after mechanical ventilation ]Diaphragm ultrasound measurement at peak inspiration in assist control and pressure support
- p0.1 measurements in controlled and spontaneous modes [ Time Frame: Less than 48 hours after mechanical ventilation ]A measure of respiratory drive obtained from the ventilator in assist control and pressure support
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04319939
|Contact: John P Kress, MDfirstname.lastname@example.org|
|Contact: Anne Pohlman, MSNemail@example.com|
|United States, Illinois|
|The University of Chicago Medical Center||Recruiting|
|Chicago, Illinois, United States, 60637|
|Contact: John P Kress, MD 773-702-6404 firstname.lastname@example.org|