Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD)
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|ClinicalTrials.gov Identifier: NCT04279821|
Recruitment Status : Recruiting
First Posted : February 21, 2020
Last Update Posted : February 26, 2020
Colonic diverticula are common in Western countries, affecting up to 60% of subjects over 70 years of age. In about 80% of patients, colonic diverticula remain asymptomatic (diverticulosis), while approximately 20% of patients may develop abdominal symptoms (symptomatic uncomplicated diverticular disease, SUDD) and, eventually, complications such as bouts of diverticulitis or bleeding.
A small proportion of patients with colonic diverticulosis may develop segmental colitis associated with diverticulosis (SCAD). SCAD is separate clinical disease with specific macroscopic (erythema, friability and ulcerations) and microscopic features characterized by chronic, mucosal inflammation involving the inter-diverticular mucosa (usually sigmoid colon) sparing the proximal colon and rectum colon.
The most common symptoms of SCAD are rectal bleeding, diarrhoea and abdominal pain.
To achieve SCAD diagnosis a correct biopsies sampling is mandatory. It is necessary to take biopsies on the borders of the diverticula and in the apparently normal adjacent mucosa as well as biopsies in both the colon proximal to the diverticular area and the rectum in order to exclude chronic inflammatory bowel disease. The spectrum of histological lesions associated with SCAD is variable, including mild non-specific inflammation and inflammatory bowel disease (IBD)-like changes.
Currently, data regarding prevalence of SCAD are scarce. It has been estimated that in patients with diverticulosis, SCAD prevalence ranged from 0.3-1.3%.
The aim of the present study is to assess prospectively the prevalence of segmental colitis associated with colon diverticulosis (SCAD), in consecutive patients with colic diverticulosis, in a tertiary university centre.
|Condition or disease|
|Diverticular Disease of Colon Diverticulosis, Colonic|
|Study Type :||Observational|
|Estimated Enrollment :||50 participants|
|Official Title:||Prevalence of Segmental Colitis Associated With Colic Diverticulosis (SCAD): an Observational Study|
|Actual Study Start Date :||February 1, 2020|
|Estimated Primary Completion Date :||February 1, 2021|
|Estimated Study Completion Date :||March 1, 2021|
Colonic diverticulosis and macroscopic signs of inflammation
No interventional study
- Number of patients with Segmental Colitis Associated With Colic Diverticulosis (SCAD) as assessed by histology [ Time Frame: 1 year ]Number of patients with histological diagnosis of SCAD in patients with endoscopic signs of inflammation of the interdiverticular mucosa
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04279821
|Contact: Bruno Annibale, MD||0633775695 ext +firstname.lastname@example.org|
|Principal Investigator:||Bruno Annibale, MD||University of Roma La Sapienza|