Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery
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|ClinicalTrials.gov Identifier: NCT04250935|
Recruitment Status : Active, not recruiting
First Posted : January 31, 2020
Last Update Posted : January 31, 2020
|Condition or disease||Intervention/treatment|
|Cognitive Dysfunction||Diagnostic Test: Patients with cognitive dysfunction|
Although postoperative cognitive dysfunction (POKD) is the most common neurological complication in patients undergoing coronary artery bypass grafting (CABG) surgery, its pathophysiology is still not fully understood. However, the quality of this dysfunction has not been properly measured. In addition to clinical tests, biomarkers are often used to detect the presence of POKD. In this study, it was aimed to evaluate the relationship between intraoperative and postoperative brain-derived neurotrophic factor serum levels and POKD in patients undergoing CABG surgery.
This prospective observational study is planned to include 30 adult patients aged 40-90 years. Patients with stroke history, neurodegenerative disease, seizure history, alcohol use, general anxiety, hearing deficit, unilateral carotid artery stenosis greater than 70%, and carotid artery bilateral stenosis greater than 50% will be excluded from the study.
This study aimed to determine perioperative changes in serum brain-derived neurotrophic factor levels in patients undergoing CABG surgery.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||The Relationship Between Neurocognitive Changes and Brain-Induced Neurotrophic Factor Levels in Patients Undergoing Coronary Artery Bypass Surgery|
|Actual Study Start Date :||January 15, 2020|
|Estimated Primary Completion Date :||August 2020|
|Estimated Study Completion Date :||October 2020|
- Diagnostic Test: Patients with cognitive dysfunction
Mini Mental Test Those with a score below 21 points
- Postoperative cognitive dysfunction [ Time Frame: 4 days ]Relationship between serum brain-derived neurotrophic factor level and cognitive dysfunction
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04250935
|Bozok University Medical Center|
|Study Director:||Yozgat Bozok University Research Hospital||Yozgat|