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Decrease in Paraoxonase Enzyme Level and Myocardial İnfarction

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT04243876
Recruitment Status : Recruiting
First Posted : January 28, 2020
Last Update Posted : January 28, 2020
Sponsor:
Information provided by (Responsible Party):
Bahadir Taslidere, Bezmialem Vakif University

Brief Summary:
Myocardial infarction is a polygenic disease that may occur due to various environmental risk factors. Mortality risk of the disease; sex, age, smoking, systolic blood pressure, total cholesterol, and high-density lipoprotein levels. The paraoxonase-1 phenotype is expressed as the paraoxonase/arylesterase ratio and is closely related to high-density lipoprotein, acting as an endogenous defense mechanism against vascular oxidative stress, thus contributing to the prevention of atherosclerosis. Serum concentration and activity depend on environmental factors as well as genetic polymorphism. This decrease in enzyme concentration causes changes in gene expression (1). Numerous data on Paraoxonase-1 levels have been found in studies, especially with decreasing serum paraoxonase and arylesterase activities with age, associated with increased risk of systemic oxidative stress and atherosclerosis in humans. Many studies have shown that serum Paraoxonase-1 activity is significantly reduced in people with myocardial infarction, dyslipidemia, atherosclerosis, and chronic kidney disease. The most important risk factor for these and similar diseases is aging. Diversity of conditions such as genetic predisposition, malnutrition, stress, and smoking, which increases vascular dysfunction due to oxidative stress, classify individuals with acute myocardial infarction according to age groups and investigate whether there is a relationship between serum Paraoxonase-1 activity and severity of coronary artery disease in young patients. The paraoxonase-1 enzyme, which is known to decrease blood levels with age, is found to be significantly lower in patients with myocardial infarction at a young age compared to the healthy control group.

Condition or disease Intervention/treatment
Myocardial Infarction High-Density Lipoid Deficiency Diagnostic Test: paraoxanase enzyme level

Detailed Description:

High-density lipoprotein (HDL), known as good cholesterol, is named because of its protective effects on the cardiovascular system. in order to summarize the mechanism of the event, cholesterol is transported from the liver to the cells and from the cells back to the liver via blood. Cholesterol and other fats are carried in packets called lipoprotein to dissolve in the blood. Those with these are two kinds of cholesterol, these low-density lipoproteins and good cholesterol can help to lower the cholesterol as well. LDL cholesterol is the main package that carries cholesterol in the blood. When the blood is high, it sticks to the inside of the veins and forms plaques around here. With the addition of cholesterol, a blood clot that formed in cracks that occur on these plaques grow the arteries and clogs them. If the blockage occurs in the heart vessels, it can cause a heart attack and stroke. Cholesterol in the blood is a part of a package called HDL-cholesterol is carried in. HDL-cholesterol prevents the accumulation of cholesterol in the veins.

It collects the cholesterol circulating in the blood and brings it to the liver to get rid of it from the body. Thus, it reduces the exposure of blood vessels to the harmful effects of cholesterol. All these effects of HDL cholesterol in the paraoxonase enzyme owes. This may be the reason why Dolat may even use another nomenclature instead of HDL in future years. A paraoxonase-1 enzyme, which is known to decrease blood level with age, is found to be significantly lower in patients with myocardial infarction at a young age compared with the healthy control group in this study, and the measurement of this enzyme level can be used as a screening test in people with risk factors.

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Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Case-Control
Time Perspective: Retrospective
Official Title: Comparison of the Relationship Between Age and Serum Paraoxonase /Arylesterase Activity of Patients With Acute Coronary Syndrome Presenting to the Emergency Department''
Actual Study Start Date : December 30, 2019
Estimated Primary Completion Date : July 30, 2020
Estimated Study Completion Date : December 31, 2020

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Heart Attack

Group/Cohort Intervention/treatment
paraoxanase
Enzyme level
Diagnostic Test: paraoxanase enzyme level
presence of paraoxonase enzyme deficiency and associated troponin elevation
Other Names:
  • troponin level
  • HDL level

Myocardial infarction
RESULTS OF ANGIOGRAPHY
Diagnostic Test: paraoxanase enzyme level
presence of paraoxonase enzyme deficiency and associated troponin elevation
Other Names:
  • troponin level
  • HDL level




Primary Outcome Measures :
  1. early diagnosis [ Time Frame: one year ]
    paraoxonase enzyme measurement



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All patients admitted to the emergency department over the age of 18
Criteria

Inclusion Criteria:

  • Those over the age of 18
  • All acute coronary syndrome patients

Exclusion Criteria:

- Patients with normal angiography


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04243876


Contacts
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Contact: Bahadir Taslidere 05326563135 drbahadir@yahoo.com
Contact: Begum sakin 05343248402 begumcalp@gmail.com

Locations
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Turkey
Bezmialem vakif university Recruiting
Istanbul, Eyalet/Yerleşke, Turkey, 34093
Contact: bahadir taslidere    05326563135    drbahadir@yahoo.com   
Contact       drbahadir@yahoo.com   
Principal Investigator: bahadir taslidere         
Sub-Investigator: begum sakin         
Sponsors and Collaborators
Bezmialem Vakif University
Investigators
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Principal Investigator: bahadir taslidere BEZMİALEM VAKİF UNİVERSİTY
  Study Documents (Full-Text)

Documents provided by Bahadir Taslidere, Bezmialem Vakif University:
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Responsible Party: Bahadir Taslidere, Associate Professor, clinical research, Bezmialem Vakif University
ClinicalTrials.gov Identifier: NCT04243876    
Other Study ID Numbers: 20/9
First Posted: January 28, 2020    Key Record Dates
Last Update Posted: January 28, 2020
Last Verified: January 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: nope

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Bahadir Taslidere, Bezmialem Vakif University:
Myocardial infarction, Paraoxonase
Additional relevant MeSH terms:
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Myocardial Infarction
Hypoalphalipoproteinemias
Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Hypolipoproteinemias
Lipid Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Dyslipidemias
Lipid Metabolism Disorders
Metabolic Diseases