Detection and Neurological Impact of Cerebrovascular Events in Cardiac Surgery Patients
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
The investigators conducted a prospective observational pilot study to explore the incidence of peri-operative covert strokes (detected by brain MRI) and the potential impact on delirium and cognitive decline in post-operative cardiac surgery patients at the Hamilton General Hospital. This pilot study assessed the feasibility of a larger prospective international cohort study exploring this objective.
Condition or disease
Silent StrokeCognitive Decline
Delirium and cognitive decline are common following cardiac surgery and increase the burden on patients and health care resources. Covert (sub-clinical) strokes are associated with these complications. The investigators conducted a prospective cohort pilot study enrolling consecutive cardiac surgery patients to receive a post-operative brain MRI and a series of questionnaires to assess for changes in cognition, physical function and delirium. Regional cerebral oxygen saturation (rSO2) was recorded during surgery with the use of near-infrared spectroscopy (NIRS) sensors placed on the patients' forehead. The primary aim was to determine the feasibility of conducting a larger study to establish an association between covert stroke and long-term cognitive decline in cardiac surgery patients.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
21 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients aged 21 years or more scheduled to undergo isolated coronary artery bypass grafting (CABG) surgery with a median sternotomy and at least one vascular risk factor.
Male or female ≥ 21 years old
Provide written informed consent
Scheduled to undergo isolated CABG through a median sternotomy approach
Have at least one of the following risk factors:
Peripheral vascular disease (previous peripheral arterial bypass, amputation due to ischemia, ABPI <0.9, or previous AAA repair)
Cerebrovascular disease (history of stroke, TIA, or carotid stenosis >70%)
Renal insufficiency (eGFR <60 mL/min/1.73m2)
Diabetes mellitus (on oral hypoglycemic agent(s) and/or insulin replacement)
Urgent CABG (in-patient awaiting revascularization for ACS or MI)
Recent smoker (within the last year)
Left ventricular ejection fraction <35%
Concomitant cardiac procedure with CABG Prior enrolment in this study
Emergency CABG surgery (immediate revascularization for hemodynamic instability)
Circulatory arrest planned during the cardiac operation
Diagnosed dementia of any types
Contra-indication for DW MRI e.g. claustrophobia, unable to lie flat for the duration of the study, pacemaker or ICD in-situ, or other metal implants