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Repetitive Transcranial Magnetic Stimulation as a Potential Tool to Reduce Sexual Arousal

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ClinicalTrials.gov Identifier: NCT04209309
Recruitment Status : Completed
First Posted : December 24, 2019
Last Update Posted : December 24, 2019
Sponsor:
Information provided by (Responsible Party):
Berthold Langguth, MD, Ph.D., University of Regensburg

Brief Summary:

Hyper- and hyposexuality occur frequently in a variety of psychiatric disorders and are difficult to treat. While there is meta-analytic evidence for the significant effect of non-invasive brain stimulation on drug and food craving, no study has investigated the potential of this technique to modulate sexual behavior. The efficacy of a single session of high-frequency repetitive transcranial magnetic stimulation (rTMS) over the left or right dorsolateral prefrontal cortex (DLPFC) to reduce sexual arousal was tested against a sham stimulation.

To test this hypothesis, we employed a randomized, double-blind, sham-controlled crossover study design. Nineteen healthy male participants received high-frequency rTMS over the left DLPFC, high-frequency rTMS over the right DLPFC and sham rTMS (each 10 Hz; 110% resting motor threshold; 60 trains with 50 pulses) in randomized and counterbalanced order with a one-week interval between stimulation sessions to avoid carryover effects. Participants were exposed to neutral and sexual cues before and after each intervention and rated their sexual arousal after each block of cue presentation.


Condition or disease Intervention/treatment Phase
Transcranial Magnetic Stimulation Device: repetitive transcranial magnetic stimulation Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 19 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: Repetitive Transcranial Magnetic Stimulation as a Potential Tool to Reduce Sexual Arousal
Actual Study Start Date : October 1, 2014
Actual Primary Completion Date : July 1, 2016
Actual Study Completion Date : July 1, 2016

Arm Intervention/treatment
Experimental: leDLPFC
single session rTMS of the left dorsolateral prefrontal cortex for 15 min (60 trains with 50 stimuli; 10 sec intertrain interval; 10 Hz; 110% RMT; 3000 pulses; coil positioning over the 10-20 EEG coordinate position F3)
Device: repetitive transcranial magnetic stimulation
Experimental: riDLPFC
single session rTMS of the right dorsolateral prefrontal cortex for 15 min (60 trains with 50 stimuli; 10 sec intertrain interval; 10 Hz; 110% RMT; 3000 pulses; coil positioning over the 10-20 EEG coordinate position F4)
Device: repetitive transcranial magnetic stimulation
Sham Comparator: shamDLPFC
single session sham rTMS over the medial prefrontal cortex for 15 min (60 trains with 50 stimuli; 10 sec intertrain interval; 10 Hz; 110% RMT; 3000 pulses; coil positioning over the midline with tilted coil)
Device: repetitive transcranial magnetic stimulation



Primary Outcome Measures :
  1. Change of sexual arousal [ Time Frame: immediately before and after the single session of rTMS ]
    short 10-item version of the Affect and Arousal Scale, which captures perceived genital, autonomic and psychological sexual arousal as well as state sexual desire



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • motor threshold below 55%
  • informed consent
  • male
  • 18-50 years
  • heterosexual
  • right handedness

Exclusion Criteria:

  • contraindication for TMS
  • somatic or mental illnesses
  • intake of psychoactive drugs
  • left handedness
  • homo- or bisexual
  • paraphilia
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Responsible Party: Berthold Langguth, MD, Ph.D., Clinical Professor, University of Regensburg
ClinicalTrials.gov Identifier: NCT04209309    
Other Study ID Numbers: 13-101-0117
First Posted: December 24, 2019    Key Record Dates
Last Update Posted: December 24, 2019
Last Verified: December 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: Not allowed based on ethics vote.

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Berthold Langguth, MD, Ph.D., University of Regensburg:
sexual arousal