Breathing Pattern, WOB and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT04209270|
Recruitment Status : Recruiting
First Posted : December 24, 2019
Last Update Posted : December 26, 2019
|Condition or disease|
|Work of Breathing ARDS Weaning Failure|
The study of the respiratory system (RS) mechanics in patients with ARDS has been focused on the initial phase of ventilatory support, with few studies observing the weaning in mechanical ventilation.The RS in patients with ARDS is characterized by a greater or lesser degree of low functional residual capacity (FRC) in relation to normal.
At the time of performing a spontaneous breathing trial, these mechanical characteristics determine the need to develop a high transpulmonary pressure during each breath, with high work of breathing (WOB) to achieve adequate alveolar ventilation.
Inspiratory muscle weakness could alter the ability to generate the necessary transpulmonary pressure over time according to the loads imposed at the time of performing a spontaneous breathing trial, with the consequent development of fatigue and ventilatory failure.
This is why the investigators propose to evaluate the association between elastic WOB and the failure of the spontaneous breathing trial.
|Study Type :||Observational [Patient Registry]|
|Estimated Enrollment :||37 participants|
|Target Follow-Up Duration:||28 Days|
|Official Title:||Breathing Pattern, Work of Breathing and Gas Exchange in Patients With Acute Respiratory Distress Syndrome During the Spontaneous Breathing Trial|
|Actual Study Start Date :||April 1, 2019|
|Estimated Primary Completion Date :||December 1, 2022|
|Estimated Study Completion Date :||December 1, 2022|
- Spontaneous breathing Trial [ Time Frame: During 60 minutes after inclusion or until the patient fails to breathe spontaneously ]Period of time in which the patient breathes spontaneously
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04209270
|Contact: Emilio Steinberg, RT||0054 email@example.com|
|Contact: Sebastian Fredes, RTfirstname.lastname@example.org|
|Principal Investigator:||Sebastian Fredes, RT||Sanatorio de la Trinidad Mitre|