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Gender Specific Responses of Overweight and Obese Adults to Sprint Interval Training

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ClinicalTrials.gov Identifier: NCT04155827
Recruitment Status : Recruiting
First Posted : November 7, 2019
Last Update Posted : March 25, 2020
Sponsor:
Information provided by (Responsible Party):
Imtiyaz Ali Mir, Universiti Tunku Abdul Rahman

Brief Summary:
Overweight and Obesity is a growing health problem worldwide. Lifestyle changes such as decreased physical activity, increased sedentary behaviour and unhealthy eating habits has contribute to this problem. According to World Health Organization (2016), more than 1.9 billion adults aged 18 years and older were overweight (39% of men and 40% of women).Regular exercise is the key contributor to energy expenditure and is essential for energy balance and weight control. Interval training (IT) has been commonly used for decades with purpose to improve body health and reduce weight loss and this exercise differs from the conventional aerobic exercise and endurance exercise as IT typically involves repeated bouts of relatively intense exercise interspersed by periods of lower- intensity effort or complete rest for recovery. One of the most common type of IT is sprint interval training (SIT). SIT involves 'supramaximal' effort (>100% VO2max) work bouts, traditionally structured as four to six 30s all-out effort and each round separated by 4 minutes of recovery period of a low intensity exercise. Potential physiological adaptation of SIT are highlighted by various studies reporting cardiovascular, skeletal muscle adaptations, increase fat oxidation that facilitate increases in both aerobic and anaerobic performance. In addition, SIT is able to improve maximal rate of oxygen consumption (VO2max), at the same time improving the peripheral vascular structure and function, enzymes of fat metabolism and increases insulin sensitivity. Previous SIT studies have included young healthy men and women, healthy obese young women, all of which have shown that SIT is effective for fat loss and improvement of some health parameters. However, whether SIT protocol is equally effective in improving the anthropometric measures in men and women remain unknown.

Condition or disease Intervention/treatment Phase
Overweight and Obesity Other: SIT Not Applicable

Detailed Description:
Total of 80 eligible male (n=40) and female (n=40) young adults will be equally recruited using block randomization and chosen based on the inclusion and exclusion criteria. Before the study, all participants will be informed of the potential risks and benefits of the study. During the study period, participants will be instructed to avoid any form of physical activity besides the study protocol. Both groups will perform SIT protocol on a electromagnetically braked cycle ergometer three times per week for 6 weeks. Every session, participants start with a 5 minutes warm up at 50- 60% of heart rate maximum (HRmax) and follow by four 30-s all out bouts intersperse with 4 minutes of recovery (passive or no load cycling). For confirmation of all-out effort, participant are required to maintain his or her cycling cadence at least 60 rpm or above. Intervention will end with a 5 minutes cool down at 50- 60% of HRmax. Total duration for each session will be 28 minutes. If a participant misses fewer than three sessions per week non- consecutively, the sessions missed will be replace at the end of period. However, if participants misses three or more sessions, he or she will be excluded from the study. Outcome measures will be assessed at baseline and at end of 6 weeks of intervention.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 80 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Gender Specific Responses of Overweight and Obese Adults to Sprint Interval Training on Anthropometric Variables
Actual Study Start Date : February 4, 2020
Estimated Primary Completion Date : August 2020
Estimated Study Completion Date : September 2020

Arm Intervention/treatment
Experimental: SIT for males Other: SIT
Sprint interval training of 4*4, with 30 seconds of all out workout followed by 4 minutes of active recovery for 4 cycles.

Experimental: SIT for females Other: SIT
Sprint interval training of 4*4, with 30 seconds of all out workout followed by 4 minutes of active recovery for 4 cycles.




Primary Outcome Measures :
  1. BMI for change [ Time Frame: At baseline (before intervention begin) and post training (end of 6 weeks). ]
  2. Waist Circumference for change [ Time Frame: At baseline (before intervention begin) and post training (end of 6 weeks). ]
  3. Total Fat % for change [ Time Frame: At baseline (before intervention begin) and post training (end of 6 weeks). ]
  4. Lean Muscle Mass for change [ Time Frame: At baseline (before intervention begin) and post training (end of 6 weeks). ]
  5. skin Fold Measurement for change [ Time Frame: At baseline (before intervention begin) and post training (end of 6 weeks). ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 25 Years   (Adult)
Sexes Eligible for Study:   All
Gender Based Eligibility:   Yes
Gender Eligibility Description:   Both genders (male & female) will be equally recruited.
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • BMI≧23kg/m2(WHO for Asia-Pacific region)
  • No history of metabolic, hormonal, orthopedic, or cardiovascular diseases
  • No current use of prescribed medication including oral contraception

Exclusion Criteria:

  • Contraindications to physical activity assessed by Physical Activity Readiness Questionnaire-PAR-Q
  • Undergoes any surgical or hormone treatment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04155827


Contacts
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Contact: Imtiyaz Ali Mir +60108040342 imtiyaz2204@yahoo.com

Locations
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Malaysia
Universiti Tunku Abdul Rahman Recruiting
Kajang, Selangor, Malaysia, 43000
Contact: Imtiyaz Ali Mir    +60108040342    imtiyaz2204@yahoo.com   
Sponsors and Collaborators
Universiti Tunku Abdul Rahman
Investigators
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Principal Investigator: Imtiyaz Ali Mir Universiti Tunku Abdul Rahman
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Responsible Party: Imtiyaz Ali Mir, Principal Investigator, Universiti Tunku Abdul Rahman
ClinicalTrials.gov Identifier: NCT04155827    
Other Study ID Numbers: UMFB1001
First Posted: November 7, 2019    Key Record Dates
Last Update Posted: March 25, 2020
Last Verified: March 2020
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Overweight
Body Weight