Epidemiological Survey and Genetic Analysis of AD Patients in Hong Kong
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|ClinicalTrials.gov Identifier: NCT04154839|
Recruitment Status : Recruiting
First Posted : November 7, 2019
Last Update Posted : November 7, 2019
This is a joint research study between The Hong Kong Polytechnic University (PolyU) and The University of Hong Kong (HKU) as titled above. In view of the increasing prevalence of atopic dermatitis (AD), the lack of complete epidemiology data on childhood and adult AD in Hong Kong and the lack of complete understanding on the genetic and environmental factors associated with it, the purpose of this study to carry out an epidemiology and genetic study that targets AD patients within the local Hong Kong population.
The investigators will search for new AD-associated genetic variants that are related to the local population and believe that the genetic profiles that arise from this project will form an important basis for the future management and treatment of AD, such as disease-risk screening strategy and therapeutic target development.
|Condition or disease|
|Atopic Dermatitis Genetic Skin Disease Eczema|
|Study Type :||Observational|
|Estimated Enrollment :||450 participants|
|Official Title:||Pilot Study: Epidemiological Survey and Genetic Analysis of Patients With Atopic Dermatitis in Hong Kong|
|Actual Study Start Date :||July 12, 2019|
|Estimated Primary Completion Date :||December 31, 2021|
|Estimated Study Completion Date :||June 30, 2022|
Atopic dermatitis group
Number of subjects in atopic dermatitis group 0 - < 6 years : 50 subjects 6 - <12 years : 50 subjects 12 - <18 years : 50 subjects Adult (>= 18 years) : 150 subjects Total no. of cases: 300 cases
>= 40 yrs : 150 subjects
- Significant SNPs [ Time Frame: through study completion, an average of 1 year ]The significant single nucleotide polymorphisms (SNPs) between control group and different AD case subgroups (different age of onset, different AD severity, different relapsing status), Cochran-Armitage trend test will be used to assess statistical significance of the association with each SNP, and Mantel-Haenszel method for two 2 × 2 allele frequency tables will be used to assess association of SNPs on chromosome X within male and female subjects.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04154839
|Contact: Mandy Chan, MBBS||+852 email@example.com|
|Contact: Judy Sham, MCoun||+852 firstname.lastname@example.org|
|Principal Investigator:||Mandy Chan, MBBS||The University of Hong Kong|