Hypoalbuminemia in Mild Acute Stroke and Cognitive Impariment Post-stroke
|ClinicalTrials.gov Identifier: NCT04135872|
Recruitment Status : Completed
First Posted : October 23, 2019
Last Update Posted : October 24, 2019
|Condition or disease||Intervention/treatment|
|Cognitive Impairment Stroke Albumin; Double||Other: strengthened nuitritional treatment|
This is a perspective stroke registry cohort study. Stroke patients were included if ：(1) acute first-ever ischemic stroke and admitted within 72 hours after onset; (2) clinical stroke diagnosis was confirmed with positive diffusion-weighted magnetic resonance imaging (DW-MRI), those with isolated posterior circulations infarcts were exclude ; (3) presented with mild stroke severity ( admission NIHSS score ≤5); (4) age between 40 and 80 years.
Clinical data including demographic characteristics, risk factors, and baseline NIHSS score were assessed and collected using a standardized table by experienced neurologists. Lab tests were performed with fasting venous blood samples within 18 hours of admission.
Patients were followed up for 6 months. The cognitive functions were assessed using the Chinese version of Montreal Cognitive Assessment (MoCA).
Contributing factors to post-stroke cognitive impariment (PSCI) were determined by comparing clinical data between PSCI and non-PSCI groups. All potential confounders were introduced into the multivariate regression models.
|Study Type :||Observational [Patient Registry]|
|Actual Enrollment :||435 participants|
|Target Follow-Up Duration:||6 Months|
|Official Title:||Relationship Between Baseline Serum Albumin Level and Cognitive Impariment in Mild Acute Ischemic Stroke|
|Actual Study Start Date :||January 1, 2017|
|Actual Primary Completion Date :||June 30, 2018|
|Actual Study Completion Date :||August 30, 2018|
hypoalbuminemia was classified as serum albumin level (SAL) ＜35g/L
Other: strengthened nuitritional treatment
improving nutritional status by nasal feeding for dysphagia or iv. albumin when serum albumin level lower than 35g/L
normal albumin level
patients with serum albumin level (SAL) of 35g/L or higher
- PSCI [ Time Frame: 6 months post-stroke ]Patients with a MoCA score of <24 were categorized as having PSCI
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04135872
|Dongguan Peoples' Hospital|
|Dongguan, Guangdong, China, 523029|
|Principal Investigator:||zhu shi||dongguan peoples hospital|