The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells Harvested From Umbilical Cords (HUVEC)
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|ClinicalTrials.gov Identifier: NCT04122794|
Recruitment Status : Recruiting
First Posted : October 10, 2019
Last Update Posted : October 10, 2019
|Condition or disease|
Mechanical testing will be performed on the Ec's to see how the cells reacts and ultimately how the blood vessel is affected.
A central role in the mechanism that defines the nature of vessel remodelling is played by endothelial cells. EC's are extremely sensitive to the frictional forces exerted on a unit of the endothelial area by blood flow. This mechanical stimulus is known as wall shear stress (WSS). WSS experienced by EC's in-vivo is unsteady due to the unsteady nature of blood flow produced during the cardiac cycle and due to the complex nature of the vascular tree.
The extent to which this applies to venous cells and tissue remains unknown and it is the focus of this study.
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||The Role of Unsteady Wall Shears Stress Stimuli on Human Umbilical Vein Endothelial Cells (HUVECs) Harvested From Umbilical Cords|
|Estimated Study Start Date :||October 14, 2019|
|Estimated Primary Completion Date :||October 14, 2020|
|Estimated Study Completion Date :||October 14, 2021|
- The identification of Endothelial Cell phenotype [ Time Frame: 2 years ]To identify this phenotype by assessing the endothelial identity markers, the endothelial to mesenchymal transition markers and the regulation of genes involved in EC quiescence.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04122794
|Contact: Fiona Leahy, CNM Researchfirstname.lastname@example.org|
|University Hospital Limerick||Recruiting|
|Principal Investigator:||Eamon Kavanagh, MD FRCSI||University Hospital of Limerick|