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Mindreading in Adults With Autism Spectrum Disorder

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ClinicalTrials.gov Identifier: NCT04010409
Recruitment Status : Recruiting
First Posted : July 8, 2019
Last Update Posted : July 8, 2019
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Condition or disease Intervention/treatment
Autism Spectrum Disorder Other: no intervention

Detailed Description:
Autism spectrum disorder (ASD) is a clinical syndrome characterized by mindreading deficits, or Theory of Mind deficits. The Reading the Mind in the Eyes task (abbreviated as the Eyes task) was developed to assess the mindreading deficits as a hallmark of social deficits of ASD. This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. All the participants will complete clinical measures and the Eyes task. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Case-Control
Time Perspective: Cross-Sectional
Official Title: Mindreading in Adults With Autism Spectrum Disorder
Actual Study Start Date : January 8, 2019
Estimated Primary Completion Date : November 2019
Estimated Study Completion Date : November 2019

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
ASD Group
Autism spectrum disorder participants, no intervention
Other: no intervention
no intervention

TD Group
Typically developmental controls,no intervention
Other: no intervention
no intervention




Primary Outcome Measures :
  1. eye tracking indicators [ Time Frame: 30 min ]
    eye tracking indicators



Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The 30 adults with ASD will be recruited from Adult ASD clinics in Department of Psychiatry, National Taiwan University Hospital.
Criteria

Inclusion Criteria:

  • Adult aged between 20 and 50 years who had a diagnosis of ASD based on DSM-5.
  • Had a full-scale IQ > 70 on WAIS-IV.

Exclusion Criteria:

  • A history of major mental illness (e.g., bipolar affective disorder, schizophrenia) or neurological diseases.
  • Visual impairment and that would preclude participation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04010409


Contacts
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Contact: Yi Ling Chien, M.D., Ph.D. 886-2-2312-3456 ext 66013 ylchien@hotmail.com

Locations
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Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Yi Ling Chien, M.D., Ph.D.    886-2-2312-3456 ext 66013    ylchien@hotmail.com   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Yi Ling Chien, M.D., Ph.D. National Taiwan University Hospital
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Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT04010409    
Other Study ID Numbers: 201809069RINA
First Posted: July 8, 2019    Key Record Dates
Last Update Posted: July 8, 2019
Last Verified: December 2018

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Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Additional relevant MeSH terms:
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Autistic Disorder
Autism Spectrum Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders