Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome
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|ClinicalTrials.gov Identifier: NCT03996382|
Recruitment Status : Recruiting
First Posted : June 24, 2019
Last Update Posted : February 19, 2020
Wild-type transthyretin cardiac amyloidosis is an underdiagnosed depository disease in which fibril monomers of misfolded amyloid protein accumulates in various tissues, including the heart, and cause tissue dysfunction.
Before onset of cardiac symptoms, many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.
This study investigates patients previously operated for idiopathic carpal tunnel syndrome to determine if they display signs and symptoms of cardiac amyloidosis.
|Condition or disease||Intervention/treatment||Phase|
|Amyloidosis Cardiac Carpal Tunnel Syndrome||Diagnostic Test: DPD Scintigraphy||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||200 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Prevalence of Wild Type Transthyretin Cardiac Amyloidosis in Patients Operated for Idiopathic Carpal Tunnel Syndrome|
|Actual Study Start Date :||June 17, 2019|
|Estimated Primary Completion Date :||November 1, 2020|
|Estimated Study Completion Date :||February 1, 2021|
Suspicion of cardiac amyloidosis
Patients who display signs of cardiac amyloidosis will be referred for further diagnosis.
Diagnostic Test: DPD Scintigraphy
Confirms/Refutes diagnosis of cardiac amyloidosis.
- Prevalence of cardiac amyloidosis. [ Time Frame: Through study completion, an average of 2 years. ]The prevalence of cardiac amyloidosis among patients previously operated for ipiopathic carpal tunnel syndrome.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03996382
|Contact: Steen Hvitfeldt Poulsenemail@example.com|
|Contact: Bertil Ladefogedfirstname.lastname@example.org|
|Department of Heart Disease||Recruiting|
|Aarhus, Denmark, 8200|
|Contact: Steen Hvitfeldt Poulsen, Professor +4530922309 email@example.com|